Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Chandra, R, Wang, Y, Shahid, RA, Vigna, SR, Freedman, NJ, and Liddle, RA. "Immunoglobulin-Like Domain Containing Receptor Mediates Fat-Stimulated Cholecystokinin Secretion." May 2013.

Scholars@Duke

Shahid, RA, Vigna, SR, and Liddle, RA. "Leukotriene B-4 Activation of TRPV1 Mediates Acute Pancreatitis Induced by Pancreatic Duct Infusion of Sodium Taurocholate in Mice." May 2012.

Scholars@Duke

Vigna, SR, Shahid, RA, and Liddle, RA. "The Role of TRPV1 in Ethanol Plus Fatty Acid-Induced Acute Pancreatitis in Mice." May 2012.

Scholars@Duke

Vigna, SR, Shahid, RA, Nathan, JD, McVey, DC, and Liddle, RA. "Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats." Pancreas 40, no. 5 (July 2011): 708-714.

PMID
21602738
Full Text

Bohorquez, DV, Vigna, SR, and Liddle, RA. "PYY-Secreting L Cells Connect to Enteric Myofibroblasts and Neurites Through Axon-Like Basal Processes." May 2011.

Scholars@Duke

Wang, Y, Chandra, R, Samsa, LA, Gooch, B, Fee, BE, Cook, JM, Vigna, SR, Grant, AO, and Liddle, RA. "Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor." American Journal of Physiology. Gastrointestinal and Liver Physiology 300, no. 4 (April 2011): G528-G537.

PMID
21183662
Full Text

Bohorquez, DV, Samsa, LA, Vigna, SR, and Liddle, RA. "The enteroendocrine PYY cell interacts with neurites of the enteric nervous system through axon-like basal process." April 2011.

Scholars@Duke

Bohórquez, DV, Chandra, R, Samsa, LA, Vigna, SR, and Liddle, RA. "Characterization of basal pseudopod-like processes in ileal and colonic PYY cells." Journal of Molecular Histology 42, no. 1 (February 2011): 3-13.

PMID
21061049
Full Text

Chandra, R, Samsa, LA, Vigna, SR, and Liddle, RA. "Pseudopod-like basal cell processes in intestinal cholecystokinin cells." Cell and Tissue Research 341, no. 2 (August 2010): 289-297.

PMID
20582553
Full Text

Romac, JM-J, Ohmuraya, M, Bittner, C, Majeed, MF, Vigna, SR, Que, J, Fee, BE, Wartmann, T, Yamamura, K-I, and Liddle, RA. "Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype." American Journal of Physiology. Gastrointestinal and Liver Physiology 298, no. 4 (April 2010): G518-G524.

PMID
20110462
Full Text

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