Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Noble, M. D., J. Romac, S. R. Vigna, and R. A. Liddle. “A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis..” Gut 57, no. 11 (November 2008): 1566–71. https://doi.org/10.1136/gut.2008.148551.

PMID
18625695
Full Text

Reeve, Joseph R., Rodger A. Liddle, John E. Shively, Terry D. Lee, David A. Keire, Peter Chew, and Steven R. Vigna. “Sequence variation outside the "active" region of dog and rabbit cholecystokinin-58 results in bioactivity differences..” Pancreas 32, no. 3 (April 2006): 306–13. https://doi.org/10.1097/01.mpa.0000218315.04954.77.

PMID
16628087
Full Text

McVey, Douglas C., Rodger A. Liddle, Jennifer Riggs-Sauthier, Nnochiri Ekwuribe, and Steven R. Vigna. “Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA..” Dig Dis Sci 50, no. 3 (March 2005): 565–73. https://doi.org/10.1007/s10620-005-2476-1.

PMID
15810644
Full Text

Reeve, Joseph R., Rodger A. Liddle, Douglas C. McVey, Steven R. Vigna, Travis E. Solomon, David A. Keire, Grace Rosenquist, et al. “Identification of nonsulfated cholecystokinin-58 in canine intestinal extracts and its biological properties..” Am J Physiol Gastrointest Liver Physiol 287, no. 2 (August 2004): G326–33. https://doi.org/10.1152/ajpgi.00520.2003.

PMID
15064233
Full Text

McVey, Douglas C., Patricia C. Schmid, Harald H. O. Schmid, and Steven R. Vigna. “Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1)..” J Pharmacol Exp Ther 304, no. 2 (February 2003): 713–22. https://doi.org/10.1124/jpet.102.043893.

PMID
12538826
Full Text

Vigna, Steven R. “The role of the amino-terminal domain of tachykinins in neurokinin-1 receptor signaling and desensitization..” Neuropeptides 37, no. 1 (February 2003): 30–35. https://doi.org/10.1016/s0143-4179(02)00147-6.

PMID
12637033
Full Text

Nathan, J. D., R. Y. Peng, Y. Wang, D. C. McVey, S. R. Vigna, and R. A. Liddle. “Primary sensory neurons: A common final pathway for inflammation in experimental pancreatitis in rats.” American Journal of Physiology  Gastrointestinal and Liver Physiology 283, no. 4 46-4 (October 1, 2002).

Scholars@Duke

Nathan, Jaimie D., Ruth Y. Peng, Yu Wang, Douglas C. McVey, Steven R. Vigna, and Rodger A. Liddle. “Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats..” Am J Physiol Gastrointest Liver Physiol 283, no. 4 (October 2002): G938–46. https://doi.org/10.1152/ajpgi.00105.2002.

PMID
12223354
Full Text

Pages