Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Vigna, S. R. “Phosphorylation and desensitization of neurokinin-1 receptor expressed in epithelial cells..” J Neurochem 73, no. 5 (November 1999): 1925–32.

PMID
10537050
Scholars@Duke

McVey, D. C., J. M. Romac, W. C. Clay, T. A. Kost, R. A. Liddle, and S. R. Vigna. “Monitor peptide binding sites are expressed in the rat liver and small intestine..” Peptides 20, no. 4 (1999): 457–64. https://doi.org/10.1016/s0196-9781(99)00026-1.

PMID
10458515
Full Text

Shetzline, M. A., R. T. Premont, J. K. Walker, S. R. Vigna, and M. G. Caron. “A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor..” J Biol Chem 273, no. 12 (March 20, 1998): 6756–62. https://doi.org/10.1074/jbc.273.12.6756.

PMID
9506976
Full Text

Vigna, S. R., R. M. Elsey, A. O. Cheek, K. F. Faull, and J. R. Reeve. “Purification, amino acid sequence, synthesis, and receptor selectivity of alligator gastrin..” Gen Comp Endocrinol 108, no. 2 (November 1997): 316–26. https://doi.org/10.1006/gcen.1997.6988.

PMID
9356227
Full Text

Blaze, C. A., P. J. Mannon, S. R. Vigna, A. R. Kherani, and B. A. Benjamin. “Peptide YY receptor distribution and subtype in the kidney: effect on renal hemodynamics and function in rats..” Am J Physiol Renal Physiol 273, no. 4 (October 1, 1997): F545–53. https://doi.org/10.1152/ajprenal.1997.273.4.F545.

PMID
29587104
Full Text

Blaze, C. A., P. J. Mannon, S. R. Vigna, A. R. Kherani, and B. A. Benjamin. “Peptide YY receptor distribution and subtype in the kidney: Effect on renal hemodynamics and function in rats.” American Journal of Physiology  Renal Physiology 273, no. 4 42-4 (October 1, 1997).

Scholars@Duke

Whitcomb, D. C., A. M. Puccio, S. R. Vigna, I. L. Taylor, and G. E. Hoffman. “Distribution of pancreatic polypeptide receptors in the rat brain..” Brain Res 760, no. 1–2 (June 20, 1997): 137–49. https://doi.org/10.1016/s0006-8993(97)00295-3.

PMID
9237528
Full Text

Oliver, A. S., and S. R. Vigna. “CCK-A- and CCK-B-like receptors in the gallbladder and stomach of the alligator (Alligator mississippiensis)..” Gen Comp Endocrinol 105, no. 1 (January 1997): 91–101. https://doi.org/10.1006/gcen.1996.6804.

PMID
9000471
Full Text

Yoshida-Yoneda, E., T. J. O-Lee, J. Y. Wei, S. R. Vigna, and Y. Taché. “Peripheral bombesin induces gastric vagal afferent activation in rats.” American Journal of Physiology  Regulatory Integrative and Comparative Physiology 271, no. 6 40-6 (December 1, 1996).

Scholars@Duke

Blaze, C. A., S. R. Vigna, P. J. Mannon, and B. A. Benjamin. “Renal denervation and the effect of peptide yy on renal blood flow in rats.” Faseb Journal 10, no. 3 (December 1, 1996).

Scholars@Duke

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