Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Mantyh, C. R., T. N. Pappas, J. A. Lapp, M. K. Washington, L. M. Neville, J. R. Ghilardi, S. D. Rogers, P. W. Mantyh, and S. R. Vigna. “Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum..” Gastroenterology 111, no. 5 (November 1996): 1272–80. https://doi.org/10.1053/gast.1996.v111.pm8898641.

PMID
8898641
Full Text

Wang, Y., A. Sostman, R. Roman, S. Stribling, S. Vigna, Y. Hannun, J. Raymond, and J. G. Fitz. “Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism..” J Biol Chem 271, no. 30 (July 26, 1996): 18107–13. https://doi.org/10.1074/jbc.271.30.18107.

PMID
8663472
Full Text

Chang, G. Q., S. R. Vigna, and S. A. Simon. “Localization of substance P NK-1 receptors in rat tongue..” Regul Pept 63, no. 2–3 (July 5, 1996): 85–89. https://doi.org/10.1016/0167-0115(96)00021-3.

PMID
8837215
Full Text

Himick, B. A., S. R. Vigna, and R. E. Peter. “Characterization of cholecystokinin binding sites in goldfish brain and pituitary.” American Journal of Physiology  Regulatory Integrative and Comparative Physiology 271, no. 1 40-1 (July 1, 1996).

Scholars@Duke

Mantyh, P. W., S. D. Rogers, J. R. Ghilardi, J. E. Maggio, C. R. Mantyh, and S. R. Vigna. “Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo..” Brain Res 719, no. 1–2 (May 6, 1996): 8–13. https://doi.org/10.1016/0006-8993(96)00050-9.

PMID
8782857
Full Text

Portbury, A. L., J. B. Furness, H. M. Young, B. R. Southwell, and S. R. Vigna. “Localisation of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract..” J Comp Neurol 367, no. 3 (April 8, 1996): 342–51. https://doi.org/10.1002/(SICI)1096-9861(19960408)367:3<342::AID-CNE2>3.0.CO;2-5.

PMID
8698896
Full Text

McVey, D. C., D. Rittschof, P. J. Mannon, and S. R. Vigna. “Localization and characterization of neuropeptide Y/peptide YY receptors in the brain of the smooth dogfish (Mustelis canis)..” Regul Pept 61, no. 3 (March 22, 1996): 167–73. https://doi.org/10.1016/0167-0115(95)00149-2.

PMID
8701032
Full Text

Pages