Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Blaze, CA, Vigna, SR, Mannon, PJ, and Benjamin, BA. "Renal denervation and the effect of peptide yy on renal blood flow in rats." Faseb Journal 10, no. 3 (December 1, 1996).

Scholars@Duke

Yoshida-Yoneda, E, O-Lee, TJ, Wei, JY, Vigna, SR, and Taché, Y. "Peripheral bombesin induces gastric vagal afferent activation in rats." The American Journal of Physiology 271, no. 6 Pt 2 (December 1996): R1584-R1593.

PMID
8997356
Full Text

Mantyh, CR, Pappas, TN, Lapp, JA, Washington, MK, Neville, LM, Ghilardi, JR, Rogers, SD, Mantyh, PW, and Vigna, SR. "Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum." Gastroenterology 111, no. 5 (November 1996): 1272-1280.

PMID
8898641
Scholars@Duke

Himick, BA, Vigna, SR, and Peter, RE. "Characterization of cholecystokinin binding sites in goldfish brain and pituitary." American Journal of Physiology Regulatory Integrative and Comparative Physiology 271, no. 1 40-1 (July 1, 1996).

Scholars@Duke

Himick, BA, Vigna, SR, and Peter, RE. "Characterization of cholecystokinin binding sites in goldfish brain and pituitary." The American Journal of Physiology 271, no. 1 Pt 2 (July 1996): R137-R143.

PMID
8760214
Full Text

Chang, GQ, Vigna, SR, and Simon, SA. "Localization of substance P NK-1 receptors in rat tongue." Regulatory Peptides 63, no. 2-3 (July 1996): 85-89.

PMID
8837215
Full Text

Wang, Y, Sostman, A, Roman, R, Stribling, S, Vigna, S, Hannun, Y, Raymond, J, and Fitz, JG. "Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism." The Journal of Biological Chemistry 271, no. 30 (July 1996): 18107-18113.

PMID
8663472
Full Text

Mantyh, PW, Rogers, SD, Ghilardi, JR, Maggio, JE, Mantyh, CR, and Vigna, SR. "Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo." Brain Research 719, no. 1-2 (May 1996): 8-13.

PMID
8782857
Full Text

Portbury, AL, Furness, JB, Young, HM, Southwell, BR, and Vigna, SR. "Localisation of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract." The Journal of Comparative Neurology 367, no. 3 (April 1996): 342-351.

PMID
8698896
Full Text

Oliver, AS, and Vigna, SR. "CCK-X receptors in the endothermic mako shark (Isurus oxyrinchus)." Gen Comp Endocrinol 102, no. 1 (April 1996): 61-73.

PMID
8860310
Full Text

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