Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Bowden, J. J., P. Baluk, P. M. Lefevre, S. R. Vigna, and D. M. McDonald. “Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa..” Am J Physiol 270, no. 3 Pt 1 (March 1996): L404–14. https://doi.org/10.1152/ajplung.1996.270.3.L404.

PMID
8638733
Full Text

Mantyh, C. R., J. E. Maggio, P. W. Mantyh, S. R. Vigna, and T. N. Pappas. “Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis..” Dig Dis Sci 41, no. 3 (March 1996): 614–20. https://doi.org/10.1007/bf02282350.

PMID
8617145
Full Text

Garland, A. M., E. F. Grady, M. Lovett, S. R. Vigna, M. M. Frucht, J. E. Krause, and N. W. Bunnett. “Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors..” Mol Pharmacol 49, no. 3 (March 1996): 438–46.

PMID
8643083
Scholars@Duke

Bowden, J. J., P. Baluk, P. M. Lefevre, S. R. Vigna, and D. M. McDonald. “Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa.” American Journal of Physiology  Lung Cellular and Molecular Physiology 270, no. 3 14-3 (March 1, 1996).

Scholars@Duke

Himick, B. A., S. R. Vigna, and R. E. Peter. “Characterization and distribution of bombesin binding sites in the goldfish hypothalamic feeding center and pituitary..” Regul Pept 60, no. 2–3 (December 14, 1995): 167–76.

PMID
8746543
Scholars@Duke

Mantyh, C. R., S. R. Vigna, R. R. Bollinger, P. W. Mantyh, J. E. Maggio, and T. N. Pappas. “Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis..” Gastroenterology 109, no. 3 (September 1995): 850–60. https://doi.org/10.1016/0016-5085(95)90394-1.

PMID
7657114
Full Text

Mantyh, P. W., E. DeMaster, A. Malhotra, J. R. Ghilardi, S. D. Rogers, C. R. Mantyh, H. Liu, A. I. Basbaum, S. R. Vigna, and J. E. Maggio. “Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation..” Science 268, no. 5217 (June 16, 1995): 1629–32. https://doi.org/10.1126/science.7539937.

PMID
7539937
Full Text

Brown, J. L., H. Liu, J. E. Maggio, S. R. Vigna, P. W. Mantyh, and A. I. Basbaum. “Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis..” J Comp Neurol 356, no. 3 (June 5, 1995): 327–44. https://doi.org/10.1002/cne.903560302.

PMID
7642798
Full Text

Mantyh, P. W., C. J. Allen, J. R. Ghilardi, S. D. Rogers, C. R. Mantyh, H. Liu, A. I. Basbaum, S. R. Vigna, and J. E. Maggio. “Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo..” Proc Natl Acad Sci U S A 92, no. 7 (March 28, 1995): 2622–26. https://doi.org/10.1073/pnas.92.7.2622.

PMID
7535928
Full Text

Mantyh, P. W., S. D. Rogers, C. J. Allen, M. D. Catton, J. R. Ghilardi, L. A. Levin, J. E. Maggio, and S. R. Vigna. “β2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human.” Journal of Neuroscience 15, no. 1 I (January 1, 1995): 152–64.

Scholars@Duke

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