Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

McVey, DC, Rittschof, D, Mannon, PJ, and Vigna, SR. "Localization and characterization of neuropeptide Y/peptide YY receptors in the brain of the smooth dogfish (Mustelis canis)." Regul Pept 61, no. 3 (March 22, 1996): 167-173.

PMID
8701032
Scholars@Duke

Bowden, JJ, Baluk, P, Lefevre, PM, Vigna, SR, and McDonald, DM. "Substance P (NK 1 ) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa." American Journal of Physiology Lung Cellular and Molecular Physiology 270, no. 3 14-3 (March 1, 1996).

Scholars@Duke

Bowden, JJ, Baluk, P, Lefevre, PM, Vigna, SR, and McDonald, DM. "Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa." The American Journal of Physiology 270, no. 3 Pt 1 (March 1996): L404-L414.

PMID
8638733
Full Text

Mantyh, CR, Maggio, JE, Mantyh, PW, Vigna, SR, and Pappas, TN. "Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis." Digestive Diseases and Sciences 41, no. 3 (March 1996): 614-620. (Review)

PMID
8617145
Full Text

Garland, AM, Grady, EF, Lovett, M, Vigna, SR, Frucht, MM, Krause, JE, and Bunnett, NW. "Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors." Mol Pharmacol 49, no. 3 (March 1996): 438-446.

PMID
8643083
Scholars@Duke

Himick, BA, Vigna, SR, and Peter, RE. "Characterization and distribution of bombesin binding sites in the goldfish hypothalamic feeding center and pituitary." Regul Pept 60, no. 2-3 (December 14, 1995): 167-176.

PMID
8746543
Scholars@Duke

Mantyh, CR, Vigna, SR, Bollinger, RR, Mantyh, PW, Maggio, JE, and Pappas, TN. "Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis." Gastroenterology 109, no. 3 (September 1995): 850-860.

PMID
7657114
Scholars@Duke

Brown, JL, Liu, H, Maggio, JE, Vigna, SR, Mantyh, PW, and Basbaum, AI. "Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis." The Journal of Comparative Neurology 356, no. 3 (June 1995): 327-344.

PMID
7642798
Full Text

Mantyh, PW, DeMaster, E, Malhotra, A, Ghilardi, JR, Rogers, SD, Mantyh, CR, Liu, H, Basbaum, AI, Vigna, SR, and Maggio, JE. "Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation." Science (New York, N.Y.) 268, no. 5217 (June 1995): 1629-1632.

PMID
7539937
Full Text

Mantyh, C, Pappas, T, and Vigna, S. "Reply." Gastroenterology 108, no. 6 (June 1995): 1954-1955.

Full Text

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