Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Mantyh, PW, Allen, CJ, Ghilardi, JR, Rogers, SD, Mantyh, CR, Liu, H, Basbaum, AI, Vigna, SR, and Maggio, JE. "Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo." Proceedings of the National Academy of Sciences of the United States of America 92, no. 7 (March 1995): 2622-2626.

PMID
7535928
Full Text

Mantyh, PW, Rogers, SD, Allen, CJ, Catton, MD, Ghilardi, JR, Levin, LA, Maggio, JE, and Vigna, SR. "β2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human." Journal of Neuroscience 15, no. 1 I (January 1, 1995): 152-164.

Scholars@Duke

Mantyh, PW, Rogers, SD, Allen, CJ, Catton, MD, Ghilardi, JR, Levin, LA, Maggio, JE, and Vigna, SR. "Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 15, no. 1 Pt 1 (January 1995): 152-164.

PMID
7823126
Scholars@Duke

Fox-Threlkeld, JAET, Daniel, EE, Fioramonti, J, Mantyh, C, Pappas, T, and Vigna, S. "How selective are the cholecystokinin antagonists in the dog? [2]." Gastroenterology 108, no. 6 (1995): 1953-1955.

Scholars@Duke

Mantyh, PW, Rogers, SD, Allen, CJ, Catton, MD, Ghilardi, JR, Levin, LA, Maggio, JE, and Vigna, SR. "β2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human." Journal of Neuroscience 15, no. 1 I (1995): 152-164.

Scholars@Duke

Snow, ND, Prpic, V, Mangel, AW, Sharara, AI, McVey, DC, Hurst, LJ, Vigna, SR, and Liddle, RA. "Regulation of cholecystokinin secretion by bombesin in STC-1 cells." American Journal of Physiology Gastrointestinal and Liver Physiology 267, no. 5 30-5 (December 8, 1994).

Scholars@Duke

Snow, ND, Prpic, V, Mangel, AW, Sharara, AI, McVey, DC, Hurst, LJ, Vigna, SR, and Liddle, RA. "Regulation of cholecystokinin secretion by bombesin in STC-1 cells." The American Journal of Physiology 267, no. 5 Pt 1 (November 1994): G859-G865.

PMID
7977748
Full Text

Garland, AM, Grady, EF, Payan, DG, Vigna, SR, and Bunnett, NW. "Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells." Biochem J 303 ( Pt 1) (October 1, 1994): 177-186.

PMID
7524481
Scholars@Duke

Mantyh, CR, Pappas, TN, and Vigna, SR. "Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract." Gastroenterology 107, no. 4 (October 1994): 1019-1030.

PMID
7926455
Scholars@Duke

Bowden, JJ, Garland, AM, Baluk, P, Lefevre, P, Grady, EF, Vigna, SR, Bunnett, NW, and McDonald, DM. "Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation." Proc Natl Acad Sci U S A 91, no. 19 (September 13, 1994): 8964-8968.

PMID
7522326
Scholars@Duke

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