Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Mantyh, C. R., S. R. Vigna, J. E. Maggio, P. W. Mantyh, R. R. Bollinger, and T. N. Pappas. “Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors..” Neuroscience Letters 178, no. 2 (September 1994): 255–59. https://doi.org/10.1016/0304-3940(94)90772-2.

PMID
7529913
Full Text

Mantyh, P. W., C. J. Allen, S. Rogers, E. DeMaster, J. R. Ghilardi, T. Mosconi, L. Kruger, P. J. Mannon, I. L. Taylor, and S. R. Vigna. “Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 14, no. 6 (June 1994): 3958–68. https://doi.org/10.1523/jneurosci.14-06-03958.1994.

PMID
8207499
Full Text

Reeve, J. R., V. E. Eysselein, F. J. Ho, P. Chew, S. R. Vigna, R. A. Liddle, and C. Evans. “Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology..” Annals of the New York Academy of Sciences 713 (March 1994): 11–21. https://doi.org/10.1111/j.1749-6632.1994.tb44047.x.

PMID
7514372
Full Text

Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. “Saturable binding of circulating peptide YY in the dorsal vagal complex of rats..” The American Journal of Physiology 266, no. 3 Pt 1 (March 1994): G511–16. https://doi.org/10.1152/ajpgi.1994.266.3.g511.

PMID
8166288
Full Text

Vigna, S. R., J. J. Bowden, D. M. McDonald, J. Fisher, A. Okamoto, D. C. McVey, D. G. Payan, and N. W. Bunnett. “Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 14, no. 2 (February 1994): 834–45. https://doi.org/10.1523/jneurosci.14-02-00834.1994.

PMID
7507985
Full Text

Liu, H., J. L. Brown, L. Jasmin, J. E. Maggio, S. R. Vigna, P. W. Mantyh, and A. I. Basbaum. “Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors..” Proceedings of the National Academy of Sciences of the United States of America 91, no. 3 (February 1994): 1009–13. https://doi.org/10.1073/pnas.91.3.1009.

PMID
7508118
Full Text

Snow, N. D., V. Prpic, A. W. Mangel, A. I. Sharara, D. C. McVey, L. J. Hurst, S. R. Vigna, and R. A. Liddle. “Regulation of cholecystokinin secretion by bombesin in STC-1 cells.” Am.J.Physiol. 267, no. 5 part 1 (January 1, 1994).

Scholars@Duke

Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. “Saturable binding of circulating peptide YY in the dorsal vagal complex of rats.” American Journal of Physiology  Gastrointestinal and Liver Physiology 266, no. 3 29-3 (January 1, 1994).

Scholars@Duke

Tyler, H. D., S. R. Vigna, D. C. McVey, and W. J. Croom Jnr. “Developmental appearance of peptide-binding sites in the small intestine of the neonatal piglet.” Can.J.Anim.Sci. 74, no. 2 (January 1, 1994): 243–49. https://doi.org/10.4141/cjas94-034.

Full Text

Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. “Saturable binding of circulating peptide YY in the dorsal vagal complex of rats.” Am.J.Physiol. 266, no. 3 part 1 (January 1, 1994).

Scholars@Duke

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