Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Mantyh, P. W., C. J. Allen, S. Rogers, E. DeMaster, J. R. Ghilardi, T. Mosconi, L. Kruger, P. J. Mannon, I. L. Taylor, and S. R. Vigna. “Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury..” J Neurosci 14, no. 6 (June 1994): 3958–68.

PMID
8207499
Scholars@Duke

Reeve, J. R., V. E. Eysselein, F. J. Ho, P. Chew, S. R. Vigna, R. A. Liddle, and C. Evans. “Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology..” Ann N Y Acad Sci 713 (March 23, 1994): 11–21. https://doi.org/10.1111/j.1749-6632.1994.tb44047.x.

PMID
7514372
Full Text

Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. “Saturable binding of circulating peptide YY in the dorsal vagal complex of rats..” Am J Physiol 266, no. 3 Pt 1 (March 1994): G511–16. https://doi.org/10.1152/ajpgi.1994.266.3.G511.

PMID
8166288
Full Text

Liu, H., J. L. Brown, L. Jasmin, J. E. Maggio, S. R. Vigna, P. W. Mantyh, and A. I. Basbaum. “Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors..” Proc Natl Acad Sci U S A 91, no. 3 (February 1, 1994): 1009–13. https://doi.org/10.1073/pnas.91.3.1009.

PMID
7508118
Full Text

Vigna, S. R., J. J. Bowden, D. M. McDonald, J. Fisher, A. Okamoto, D. C. McVey, D. G. Payan, and N. W. Bunnett. “Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells..” J Neurosci 14, no. 2 (February 1994): 834–45.

PMID
7507985
Scholars@Duke

Ghilardi, J. R., C. J. Allen, S. R. Vigna, D. C. McVey, and P. W. Mantyh. “Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons..” Brain Res 633, no. 1–2 (January 7, 1994): 33–40. https://doi.org/10.1016/0006-8993(94)91519-9.

PMID
8137166
Full Text

Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. “Saturable binding of circulating peptide YY in the dorsal vagal complex of rats.” Am.J.Physiol. 266, no. 3 part 1 (January 1, 1994).

Scholars@Duke

Kaplan, A. M., and S. R. Vigna. “Gastric inhibitory polypeptide (GIP) binding sites in rat brain..” Peptides 15, no. 2 (1994): 297–302. https://doi.org/10.1016/0196-9781(94)90016-7.

PMID
8008635
Full Text

Snow, N. D., V. Prpic, A. W. Mangel, A. I. Sharara, D. C. McVey, L. J. Hurst, S. R. Vigna, and R. A. Liddle. “Regulation of cholecystokinin secretion by bombesin in STC-1 cells.” Am.J.Physiol. 267, no. 5 part 1 (January 1, 1994).

Scholars@Duke

Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. “Saturable binding of circulating peptide YY in the dorsal vagal complex of rats.” American Journal of Physiology  Gastrointestinal and Liver Physiology 266, no. 3 29-3 (January 1, 1994).

Scholars@Duke

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