Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Tamas, James W., Charles Y. Kim, Linnan Tang, Stuart J. Knechtle, and Paul V. Suhocki. “Percutaneous Splenorenal Shunt Creation in a Patient with Chronic Portomesenteric Thrombosis.” J Vasc Interv Radiol 31, no. 9 (September 2020): 1408–9. https://doi.org/10.1016/j.jvir.2020.04.009.

PMID
32868015
Full Text

Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020). https://doi.org/10.1172/jci.insight.129983.

PMID
32352934
Full Text

Kwun, Jean, and Stuart Knechtle. “Experimental modeling of desensitization: What have we learned about preventing AMR?” Am J Transplant 20 Suppl 4 (June 2020): 2–11. https://doi.org/10.1111/ajt.15873.

PMID
32538533
Full Text

Sawitzki, Birgit, Paul N. Harden, Petra Reinke, Aurélie Moreau, James A. Hutchinson, David S. Game, Qizhi Tang, et al. “Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.” Lancet 395, no. 10237 (May 23, 2020): 1627–39. https://doi.org/10.1016/S0140-6736(20)30167-7.

PMID
32446407
Full Text

Kwun, Jean, Brian Ezekian, Miriam Manook, Jaeberm Park, Janghoon Yoon, Kyle Freischlag, Mingqing Song, et al. “Targeting Calcium Release-activated Calcium Channel Is Not Sufficient to Prevent Rejection in Nonhuman Primate Kidney Transplantation.” Transplantation 104, no. 5 (May 2020): 970–80. https://doi.org/10.1097/TP.0000000000003078.

PMID
32317615
Full Text

Schinstock, Carrie A., Roslyn B. Mannon, Klemens Budde, Anita S. Chong, Mark Haas, Stuart Knechtle, Carmen Lefaucheur, et al. “Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.” Transplantation 104, no. 5 (May 2020): 911–22. https://doi.org/10.1097/TP.0000000000003095.

PMID
31895348
Full Text

Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Annette M. Jackson, Stuart J. Knechtle, and Jean Kwun. “B cells in transplant tolerance and rejection: friends or foes?” Transpl Int 33, no. 1 (January 2020): 30–40. https://doi.org/10.1111/tri.13549.

PMID
31705678
Full Text

VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.

PMID
32417770
Full Text

Jelly, E. T., W. Kendall, R. Schmitz, S. J. Knechtle, D. L. Sudan, A. Joseph, J. Roper, J. Kwun, and A. Wax. “Novel implementations of optical coherence tomography for clinical applications in the lower gastrointestinal tract.” In Optics Infobase Conference Papers, Vol. Part F180-OCT-2020, 2020.

Scholars@Duke

Pages