Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Knechtle, S. J., M. F. Fleming, K. L. Barry, D. Steen, J. D. Pirsch, G. R. Hafez, A. M. D’Alessandro, A. Reed, H. W. Sollinger, and M. Kalayoglu. “Liver transplantation for alcoholic liver disease.” Surgery 112, no. 4 (October 1992): 694–701.

PMID
1411940
Scholars@Duke

Sollinger, H. W., T. M. Sasaki, A. M. D’Alessandro, S. J. Knechtle, J. D. Pirsch, M. Kalayoglu, and F. O. Belzer. “Indications for enteric conversion after pancreas transplantation with bladder drainage.” Surgery 112, no. 4 (October 1992): 842–45.

PMID
1411959
Scholars@Duke

Belzer, F. O., A. M. D’Alessandro, R. M. Hoffmann, S. J. Knechtle, A. Reed, J. D. Pirsch, M. Kalayoglu, and H. W. Sollinger. “The use of UW solution in clinical transplantation. A 4-year experience.” Ann Surg 215, no. 6 (June 1992): 579–83. https://doi.org/10.1097/00000658-199206000-00004.

PMID
1632679
Full Text

Pirsch, J. D., A. M. D’Alessandro, H. W. Sollinger, S. J. Knechtle, A. Reed, M. Kalayoglu, and F. O. Belzer. “Hyperlipidemia and transplantation: etiologic factors and therapy.” J Am Soc Nephrol 2, no. 12 Suppl (June 1992): S238–42. https://doi.org/10.1681/ASN.V212s238.

PMID
1498281
Full Text

Wang, J., S. Jiao, J. A. Wolff, and S. J. Knechtle. “Gene transfer and expression in rat cardiac transplants.” Transplantation 53, no. 3 (March 1992): 703–5.

PMID
1549875
Scholars@Duke

Knechtle, S. J., J. Wang, W. J. Burlingham, M. Beeskau, R. Subramanian, and H. W. Sollinger. “The influence of RS-61443 on antibody-mediated rejection.” Transplantation 53, no. 3 (March 1992): 699–701.

PMID
1549873
Scholars@Duke

BELZER, F. O., J. H. SOUTHARD, R. M. HOFFMANN, R. J. PLOEG, S. J. KNECHTLE, A. M. DALESSANDRO, J. D. PIRSCH, M. KALAYOGLU, and H. W. SOLLINGER. “EVALUATION OF PRESERVATION OF THE VARIOUS ORGANS FOR TRANSPLANTATION.” In Transplantation and Clinical Immunology, Vol 24, edited by J. L. Touraine, J. Traeger, H. Betuel, J. M. Dubernard, J. P. Revillard, and C. Dupuy, 18:199–208. ELSEVIER SCIENCE PUBL B V, 1992.

Scholars@Duke

Pirsch, J. D., A. M. D’Alessandro, H. W. Sollinger, R. M. Hoffmann, E. Roecker, B. J. Voss, D. Lorentzen, S. J. Knechtle, A. Reed, and M. Kalayoglu. “The effect of donor age, recipient age, and HLA match on immunologic graft survival in cadaver renal transplant recipients.” Transplantation 53, no. 1 (January 1992): 55–59. https://doi.org/10.1097/00007890-199201000-00010.

PMID
1733086
Full Text

D’Alessandro, A. M., M. Kalayoglu, J. D. Pirsch, C. Corwith, S. J. Knechtle, A. Reed, and F. O. Belzer. “FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients.” Transplant Proc 23, no. 6 (December 1991): 2987–88.

PMID
1721335
Scholars@Duke

Pirsch, J. D., M. Kalayoglu, A. M. D’Alessandro, S. J. Knechtle, A. Reed, H. W. Sollinger, and F. O. Belzer. “Pulmonary infiltrates and eosinophilia in an FK 506 liver transplant recipient.” Transplant Proc 23, no. 6 (December 1991): 3195–96.

PMID
1721406
Scholars@Duke

Pages