Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Sasaki, T., J. D. Pirsch, A. M. D’Alessandro, S. J. Knechtle, M. Kalayoglu, F. O. Belzer, and H. W. Sollinger. “Simultaneous pancreas-kidney transplantation at University of Wisconsin-Madison Hospital.” Clin Transpl, 1991, 135–39.

PMID
1820111
Scholars@Duke

Knechtle, S. J., J. Wang, M. Beeskau, W. J. Burlingham, H. W. Sollinger, and F. O. Belzer. “Effect of RS-61443 in preventing rejection in sensitized recipients.” Surgical Forum 41 (December 1, 1990): 380–81.

Scholars@Duke

Knechtle, S. J., and H. C. Filston. “Anomalous biliary ducts associated with duodenal atresia.” J Pediatr Surg 25, no. 12 (December 1990): 1266–69. https://doi.org/10.1016/0022-3468(90)90527-g.

PMID
2286903
Full Text

KALAYOGLU, M., A. M. DALESSANDRO, H. W. SOLLINGER, R. M. HOFFMANN, S. J. KNECHTLE, A. REED, J. D. PIRSCH, and F. O. BELZER. “ORTHOTOPIC LIVER-TRANSPLANTATION WITH REDUCED-SIZE LIVERS.” In Hepatology, 12:838–838. W B SAUNDERS CO, 1990.

Scholars@Duke

D’Alessandro, A. M., J. D. Pirsch, J. S. Melzer, H. W. Sollinger, M. Kalayoglu, A. Reed, S. J. Knechtle, and F. O. Belzer. “Use of OKT3 in kidney, pancreas, and liver transplantation.” Transplant Proc 22, no. 4 (August 1990): 1748–49.

PMID
2117796
Scholars@Duke

D’Alessandro, A. M., H. W. Sollinger, R. M. Hoffmann, M. Kalayoglu, J. S. Melzer, A. Reed, S. J. Knechtle, J. D. Pirsch, and F. O. Belzer. “Experience with combined hepatic, pancreaticoduodenal, and renal procurement with UW solution.” Transplant Proc 22, no. 4 (August 1990): 2076–77.

PMID
2389527
Scholars@Duke

Kalayoglu, M., A. M. D’Alessandro, H. W. Sollinger, R. M. Hoffmann, J. D. Pirsch, J. S. Melzer, A. Reed, S. J. Knechtle, and F. O. Belzer. “Experience with reduced-size liver transplantation in infants and children.” Transplant Proc 22, no. 4 (August 1990): 1489–91.

PMID
2389376
Scholars@Duke

Halperin, E. C., S. J. Knechtle, R. C. Harland, Y. Yamaguchi, M. Sontag, and R. R. Bollinger. “Irradiation for xenogeneic transplantation.” Radiother Oncol 18, no. 1 (May 1990): 29–37. https://doi.org/10.1016/0167-8140(90)90020-w.

PMID
2193319
Full Text

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