Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Wolfe, J. A., S. J. Knechtle, J. Burchette, R. R. Bollinger, and F. Sanfilippo. “Phenotype and patterns of inflammatory cell infiltration associated with rejection or acceptance of rat liver allografts.” Transplant Proc 19, no. 1 Pt 1 (February 1987): 364–68.

PMID
3547823
Scholars@Duke

Knechtle, S. J., P. C. Kolbeck, S. Tsuchimoto, A. Coundouriotis, F. Sanfilippo, and R. R. Bollinger. “Humoral rejection of rat hepatic transplants by passive transfer of serum.” Transplant Proc 19, no. 1 Pt 2 (February 1987): 1072–76.

PMID
3547849
Scholars@Duke

Knechtle, S. J., P. C. Kolbeck, S. Tsuchimoto, A. Coundouriotis, F. Sanfilippo, and R. R. Bollinger. “Hepatic transplantation into sensitized recipients. Demonstration of hyperacute rejection.” Transplantation 43, no. 1 (January 1987): 8–12. https://doi.org/10.1097/00007890-198701000-00003.

PMID
3541329
Full Text

Cruise, J. L., S. J. Knechtle, R. R. Bollinger, C. Kuhn, and G. Michalopoulos. “α1-Adrenergic effects and liver regeneration.” Hepatology 7, no. 6 (1987): 1189–94.

Scholars@Duke

Knechtle, S. J., P. Kolbeck, S. Tsuchimoto, F. Sanfilippo, and R. R. Bollinger. “Hyperacute rejection of liver transplants in rats.” Curr Surg 43, no. 4 (July 1986): 303–5.

PMID
3527575
Scholars@Duke

Knechtle, S. J., E. C. Halperin, T. Saad, and R. R. Bollinger. “Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine.” J Heart Transplant 5, no. 3 (May 1986): 254–61.

PMID
3302172
Scholars@Duke

Knechtle, S. J., E. C. Halperin, C. E. Murphy, T. Saad, K. Abernethy, D. Miller, and R. R. Bollinger. “The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection.” J Heart Transplant 4, no. 5 (September 1985): 541–45.

PMID
3916531
Scholars@Duke

Inman, R. D., P. B. Redecha, S. J. Knechtle, E. S. Schned, I. van de Rijn, and C. L. Christian. “Identification of bacterial antigens in circulating immune complexes of infective endocarditis.” J Clin Invest 70, no. 2 (August 1982): 271–80. https://doi.org/10.1172/jci110614.

PMID
6808025
Full Text

Kawata, Kazuhito, Masanobu Tsuda, Guo-Xiang Yang, Weici Zhang, Hajime Tanaka, Koichi Tsuneyama, Patrick Leung, et al. “Identification of Potential Cytokine Pathways for Therapeutic Intervention in Murine Primary Biliary Cirrhosis.” Plos One 8, no. 9 (n.d.): e74225–e74225. https://doi.org/10.1371/journal.pone.0074225.

Full Text

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