Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Kwun, Jean, Miriam Manook, Eugenia Page, Christopher Burghuber, Jungjoo Hong, and Stuart J. Knechtle. “Crosstalk Between T and B Cells in the Germinal Center After Transplantation.” Transplantation 101, no. 4 (April 2017): 704–12. https://doi.org/10.1097/TP.0000000000001588.

PMID
27906827
Full Text

Xing, Minzhi, Sonali Sakaria, Renumathy Dhanasekaran, Samir Parekh, James Spivey, Stuart J. Knechtle, Di Zhang, and Hyun S. Kim. “Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma.” Cardiovasc Intervent Radiol 40, no. 3 (March 2017): 410–20. https://doi.org/10.1007/s00270-016-1505-0.

PMID
27900445
Full Text

Schadde, Erik, Christopher Tsatsaris, Marzena Swiderska-Syn, Stefan Breitenstein, Martin Urner, Roman Schimmer, Christa Booy, et al. “Hypoxia of the growing liver accelerates regeneration.” Surgery 161, no. 3 (March 2017): 666–79. https://doi.org/10.1016/j.surg.2016.05.018.

PMID
27436690
Full Text

Schroder, Paul M., Brian Ezekian, Mandy Ford, Stuart J. Knechtle, and Jean Kwun. “Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.” Front Immunol 8 (2017): 1615. https://doi.org/10.3389/fimmu.2017.01615.

PMID
29218048
Full Text

Barbas, A. S., and S. J. Knechtle. “Expanding the Donor Pool With Normothermic Ex Vivo Liver Perfusion: The Future Is Now.” Am J Transplant 16, no. 11 (November 2016): 3075–76. https://doi.org/10.1111/ajt.13959.

PMID
27402131
Full Text

Demetris, A. J., C. Bellamy, S. G. Hübscher, J. O’Leary, P. S. Randhawa, S. Feng, D. Neil, et al. “2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection.” Am J Transplant 16, no. 10 (October 2016): 2816–35. https://doi.org/10.1111/ajt.13909.

PMID
27273869
Full Text

Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.” Am J Transplant 16, no. 9 (September 2016): 2612–23. https://doi.org/10.1111/ajt.13789.

PMID
26990829
Full Text

Burghuber, C. K., J. Kwun, E. J. Page, M. Manook, A. C. Gibby, F. V. Leopardi, M. Song, et al. “Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.” Am J Transplant 16, no. 6 (June 2016): 1726–38. https://doi.org/10.1111/ajt.13688.

PMID
26705099
Full Text

Pages