Susanna Naggie, MD

Associate Professor of Medicine
Vice Dean for Clinical Research
Member in the Duke Clinical Research Institute
Campus mail 300 West Morgan St, Suite 800, Durham, NC 27701
Phone (919) 684-2584
Email address susanna.naggie@duke.edu

Dr. Susanna Naggie completed her medical education at Johns Hopkins School of Medicine and her internal medicine training at Duke University Medical Center (DUMC), where she also served as a Chief Resident in Internal Medicine.  She completed her Infectious Diseases (ID) fellowship training at Duke and then joined the faculty in the Division of ID. She is an Associate Professor of Medicine with Tenure and currently holds joint appointments at the Duke Clinical Research Institute (DCRI, Director of ID Research), and at the Durham Veterans Affairs Medical Center (DVAMC). Dr. Naggie has dedicated her academic career to the care of patients with HIV and viral hepatitis, with a research program focused on understanding the mechanisms of accelerated liver fibrogenesis in this population and the extrahepatic health outcomes attributed to HCV in persons with HIV infection. In addition to her investigator-initiated research program, Dr. Naggie is also involved in multiple clinical trials and clinical registries with a particular focus on HIV and liver disease. She is the prior co-Chair of the AASLD/IDSA HCV Guidance Committee and is currently Chair of the AIDS Clinical Trials Group Viral Hepatitis Transformative Science Group Committee and a member of the DHHS Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and the CDC/NIH/IDSA-HIVMA Opportunistic Infections Guideline Committee. For the past two years Dr. Naggie has served as the Medical Director of the Duke Department of Medicine Clinical Research Unit.

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 2007 - 2009
  • Chief Medical Resident - VAMC, Medicine, Duke University, 2006 - 2007
  • Medical Resident, Medicine, Duke University, 2002 - 2005
  • M.D., Johns Hopkins University, 2002

Publications

Clement, Meredith, Mira Nicchitta, Alicia Ellis, Sarah Hale, Hrishikesh Chakraborty, Kara McGee, Cedar Eagle, et al. “Outcomes for PrEP Users in the Southern US: Persistence and STIs.” In Aids Research and Human Retroviruses, 34:258–258. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Proeschold-Bell, Rae Jean, Donna M. Evon, Christina Makarushka, John B. Wong, Santanu K. Datta, Jia Yao, Ashwin A. Patkar, et al. “The Hepatitis C-Alcohol Reduction Treatment (Hep ART) intervention: Study protocol of a multi-center randomized controlled trial.” Contemp Clin Trials 72 (September 2018): 73–85. https://doi.org/10.1016/j.cct.2018.07.003.

PMID
30006024
Full Text

MacBrayne, Christine E., Kristen M. Marks, Daniel S. Fierer, Susanna Naggie, Raymond T. Chung, Michael D. Hughes, Arthur Y. Kim, et al. “Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate.” The Journal of Antimicrobial Chemotherapy 73, no. 8 (August 2018): 2112–19. https://doi.org/10.1093/jac/dky146.

PMID
29746648
Full Text

Okeke, Nwora Lance, Fawaz Alenezi, Gerald S. Bloomfield, Allison Dunning, Meredith E. Clement, Svati H. Shah, Susanna Naggie, and Eric J. Velazquez. “Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.” J Card Fail 24, no. 8 (August 2018): 496–503. https://doi.org/10.1016/j.cardfail.2018.06.003.

PMID
29964194
Full Text

Naggie, Susanna, Marzena Swiderska-Syn, Steve Choi, Sam Lusk, Audrey Lan, Guido Ferrari, Wing-Kin Syn, Cynthia D. Guy, and Anna Mae Diehl. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.” Open Forum Infect Dis 5, no. 7 (July 2018): ofy138. https://doi.org/10.1093/ofid/ofy138.

PMID
29992177
Full Text

Kleinstein, Sarah E., Patrick R. Shea, Luisa M. Stamm, Mark Sulkowski, David B. Goldstein, and Susanna Naggie. “Association of CYP2B6 Single-Nucleotide Polymorphisms Altering Efavirenz Metabolism With Hepatitis C Virus (HCV) Treatment Relapse Among Human Immunodeficiency Virus/HCV-Coinfected African Americans Receiving Ledipasvir/Sofosbuvir in the ION-4 Trial.” Clin Infect Dis 66, no. 12 (June 1, 2018): 1953–56. https://doi.org/10.1093/cid/cix1051.

PMID
29522085
Full Text

Clement, Meredith E., Lauren F. Collins, Julius M. Wilder, Michael Mugavero, Taryn Barker, and Susanna Naggie. “Hepatitis C Virus Elimination in the Human Immunodeficiency Virus-Coinfected Population: Leveraging the Existing Human Immunodeficiency Virus Infrastructure.” Infect Dis Clin North Am 32, no. 2 (June 2018): 407–23. https://doi.org/10.1016/j.idc.2018.02.005.

PMID
29778263
Full Text

Wilder, Julius M., Jia Yao, Makarushka Christina, Donna Evon, Michael W. Fried, Susanna Naggie, Andrew J. Muir, and Rae Jean Proeschold-Bell. “ASSOCIATIONS OF ALCOHOL CONSUMPTION MOTIVES WITH DEPRESSION AND PAIN AMONG INDIVIDUALS WITH HEPATITIS C.” In Gastroenterology, 154:S1121–22. W B SAUNDERS CO-ELSEVIER INC, 2018.

Scholars@Duke

Carlton-Smith, C., J. A. Holmes, S. Naggie, A. Lidofsky, G. M. Lauer, A. Y. Kim, R. T. Chung, and R. T. of the ACTG A5327 study group. “IFN-free therapy is associated with restoration of type I IFN response in HIV-1 patients with acute HCV infection who achieve SVR.” J Viral Hepat 25, no. 5 (May 2018): 465–72. https://doi.org/10.1111/jvh.12836.

PMID
29193564
Full Text

Okeke, Nwora Lance, Damian M. Craig, Michael J. Muehlbauer, Olga Ilkayeva, Meredith E. Clement, Susanna Naggie, and Svati H. Shah. “Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.” Metabolomics 14, no. 3 (March 2018). https://doi.org/10.1007/s11306-018-1318-z.

PMID
30760970
Full Text

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