Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Coffman, TM. "The inextricable role of the kidney in hypertension." The Journal of Clinical Investigation 124, no. 6 (June 2, 2014): 2341-2347. (Review)

PMID
24892708
Full Text

Wang, L, Fields, TA, Pazmino, K, Dai, Q, Burchette, JL, Howell, DN, Coffman, TM, and Spurney, RF. "Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622))." Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126-.

Full Text

Xie, L, Sparks, MA, Li, W, Qi, Y, Liu, C, Coffman, TM, and Johnson, GA. "Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice." Nmr in Biomedicine 26, no. 12 (December 1, 2013): 1853-1863.

Full Text

Xie, L, Sparks, MA, Li, W, Qi, Y, Liu, C, Coffman, TM, and Johnson, GA. "Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice." NMR Biomed 26, no. 12 (December 2013): 1853-1863.

PMID
24154952
Full Text

Dimke, H, Sparks, MA, Frische, S, Coffman, TM, and Quaggin, SE. "Tubular Vegfa is Required for Renal Microvasculature and Oxygen Sensing." American-Heart-Association High Blood Pressure Research Scientific Sessions. New Orleans, LA. September 11, 2013 - September 14, 2013.: LIPPINCOTT WILLIAMS & WILKINS, September 1, 2013.

Scholars@Duke

Breyer, MD, Coffman, TM, Flessner, MF, Fried, LF, Harris, RC, Ketchum, CJ, Kretzler, M, Nelson, RG, Sedor, JR, Susztak, K, and Kidney Research National Dialogue (KRND), . "Diabetic nephropathy: a national dialogue." Clinical Journal of the American Society of Nephrology : Cjasn 8, no. 9 (September 2013): 1603-1605.

PMID
23788618
Full Text

Sparks, MA, Stegbauer, J, Chen, D, Gomez, JA, Herrera, M, Gurley, SB, and Coffman, TM. "Compensatory Activation of the Sympathetic Nervous System after Deletion of Angiotensin Type 1 Receptors from Vascular Smooth Muscle Cells." September 2013.

Scholars@Duke

Konvalinka, A, Zhou, J, Dimitromanolakis, A, Drabovich, AP, Fang, F, Gurley, S, Coffman, T, John, R, Zhang, S-L, Diamandis, EP, and Scholey, JW. "Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC)." The Journal of Biological Chemistry 288, no. 34 (August 2013): 24834-24847.

PMID
23846697
Full Text

Herrera, M, and Coffman, TM. "Control of electrolyte balance through ubiquitination." Proc Natl Acad Sci U S A 110, no. 19 (May 7, 2013): 7535-7536.

PMID
23613582
Full Text

Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, and Coffman, TM. "Response to lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein." Hypertension (Dallas, Tex. : 1979) 61, no. 4 (April 2013): e32-null. (Letter)

PMID
23607135
Full Text

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