Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, and Coffman, TM. "Response to Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type-1 Receptor Protein." HYPERTENSION 61, no. 4 (April 2013): E32-E32.

PMID
23607135
Full Text

Ortiz-Melo, D, and Coffman, TM. "A trip to inner space: insights into salt balance from cosmonauts." Cell Metab 17, no. 1 (January 8, 2013): 1-2.

PMID
23312276
Full Text

Sparks, MA, Makhanova, NA, Griffiths, RC, Snouwaert, JN, Koller, BH, and Coffman, TM. "Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death." Hypertension 61, no. 1 (January 2013): 166-173.

PMID
23150508
Full Text

Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, and Coffman, TM. "Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein." Hypertension 61, no. 1 (January 2013): 253-258.

PMID
23150519
Full Text

Breyer, MD, Coffman, TM, Flessner, MF, Fried, LF, Harris, RC, Ketchum, CJ, Kretzler, M, Nelson, RG, Sedor, JR, and Susztak, K. "Diabetic nephropathy: A national dialogue." Clinical Journal of the American Society of Nephrology 8, no. 9 (2013): 1603-1605.

PMID
23788618
Full Text

Pippin, JW, Sparks, MA, Glenn, ST, Buitrago, S, Coffman, TM, Duffield, JS, Gross, KW, and Shankland, SJ. "Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease." American Journal of Pathology 183, no. 2 (2013): 542-557.

PMID
23769837
Full Text

Konvalinka, A, Zhou, J, Dimitromanolakis, A, Drabovich, AP, Fang, F, Gurley, S, Coffman, T, John, R, Zhang, S-L, Diamandis, EP, and Scholey, JW. "Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC)." Journal of Biological Chemistry 288, no. 34 (2013): 24834-24847.

PMID
23846697
Full Text

Le, TH, Crowley, SD, Gurley, SB, and Coffman, TM. "The Renin-Angiotensin System." Seldin and Geibisch's The Kidney 1 (2013): 427-450.

Full Text

Dolber, PC, Jin, H, Nassar, R, Coffman, TM, Gurley, SB, and Fraser, MO. "The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice (Accepted)." Neurourology and Urodynamics (2013).

PMID
25048174
Full Text

Zhang, J-D, Patel, MB, Song, Y-S, Griffiths, R, Burchette, J, Ruiz, P, Sparks, MA, Yan, M, Howell, DN, Gomez, JA, Spurney, RF, Coffman, TM, and Crowley, SD. "A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension." Circ Res 110, no. 12 (June 8, 2012): 1604-1617.

PMID
22534490
Full Text

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