Thomas Myron Coffman, MD

Professor of Medicine
James R. Clapp Professor of Medicine, in the School of Medicine
Professor in Cell Biology
Professor in Immunology
Campus mail Duke Box 103015, Durham, NC 27710
Phone (919) 684-9788
Email address coffm002@duke.edu

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Education and Training

  • Fellowship in Nephrology, Duke University School of Medicine, 1983 - 1985
  • M.D., Ohio State University, 1980

Publications

Crowley, SD, and Coffman, TM. "Recent advances involving the renin-angiotensin system." Exp Cell Res 318, no. 9 (May 15, 2012): 1049-1056. (Review)

PMID
22410251
Full Text

Chen, D, and Coffman, TM. "The kidney and hypertension: lessons from mouse models." Can J Cardiol 28, no. 3 (May 2012): 305-310. (Review)

PMID
22482395
Full Text

Herrera, M, and Coffman, TM. "The kidney and hypertension: novel insights from transgenic models." Curr Opin Nephrol Hypertens 21, no. 2 (March 2012): 171-178. (Review)

PMID
22274801
Full Text

Gembardt, F, Veghel, RV, Coffman, TM, Schultheiss, H-P, Danser, AHJ, and Walther, T. "Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors." Hypertension Research 35, no. 5 (2012): 547-551.

PMID
22278624
Full Text

Cyphert, JM, Allen, IC, Church, RJ, Latour, AM, Snouwaert, JN, Coffman, TM, and Koller, BH. "Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse." American Journal of Physiology - Lung Cellular and Molecular Physiology 302, no. 1 (2012): L140-L151.

PMID
21984570
Full Text

Stegbauer, J, Gurley, SB, Sparks, MA, Woznowski, M, Kohan, DE, Yan, M, Lehrich, RW, and Coffman, TM. "AT1 receptors in the collecting duct directly modulate the concentration of urine." J Am Soc Nephrol 22, no. 12 (December 2011): 2237-2246.

PMID
22052052
Full Text

Coffman, TM. "Under pressure: the search for the essential mechanisms of hypertension. (Published online)" Nat Med 17, no. 11 (November 7, 2011): 1402-1409. (Review)

PMID
22064430
Full Text

Briet, M, Barhoumi, T, Sierra, C, Coffman, TM, Paradis, P, and Schiffrin, EL. "Aldosterone-Induced Small Artery Remodeling and Endothelial Dysfunction Requires Functional Angiotensin Type 1a Receptor." November 2011.

PMID
27045029
Scholars@Duke

Crowley, SD, Zhang, J, Herrera, M, Griffiths, R, Ruiz, P, and Coffman, TM. "Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension." Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1124-F1130.

PMID
21849491
Full Text

Facemire, CS, Nguyen, M, Jania, L, Beierwaltes, WH, Kim, H-S, Koller, BH, and Coffman, TM. "A major role for the EP4 receptor in regulation of renin." Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1035-F1041.

PMID
21835766
Full Text

Pages