Tomokazu Souma, MD, PhD

Assistant Professor in Medicine
Affiliate of the Regeneration Next Initiative
Email address tomokazu.souma@duke.edu

Education and Training

  • Post-doctoral Fellowship, Feinberg Cardiovascular Research Institute, Northwestern University, 2013 - 2014
  • Post-doctoral Fellowship, Department Of Medical Biochemistry, Tohoku University (Japan), 2012 - 2013
  • Ph.D., Tohoku University (Japan), 2012
  • M.D., Shimane University, 2004

Publications

Thomson, Benjamin R., Tomokazu Souma, Stuart W. Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M. Siggs, Liang Feng, et al. “Angiopoietin-1 is required for Schlemm's canal development in mice and humans.” J Clin Invest 127, no. 12 (December 1, 2017): 4421–36. https://doi.org/10.1172/JCI95545.

PMID
29106382
Full Text

Liu, Pan, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, and Jing Jin. “Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation.” J Vis Exp, no. 127 (September 6, 2017). https://doi.org/10.3791/56278.

PMID
28930983
Full Text

Bailey, Jessica Cooke, Puya Gharahkhani, Stuart W. Tompson, Tomokazu Souma, Owen Siggs, Terri L. Young, Angelo P. Tanna, et al. “Association of ANGPT1 with Primary Open Angle Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.

Scholars@Duke

Nezu, Masahiro, Tomokazu Souma, Lei Yu, Hiroki Sekine, Nobuyuki Takahashi, Andrew Zu-Sern Wei, Sadayoshi Ito, et al. “Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.” Sci Signal 10, no. 479 (May 16, 2017). https://doi.org/10.1126/scisignal.aam5711.

PMID
28512147
Full Text

Liu, Pan, Jan Wysocki, Peter Serfozo, Minghao Ye, Tomokazu Souma, Daniel Batlle, and Jing Jin. “A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13.” Sci Rep 7 (April 5, 2017): 45473. https://doi.org/10.1038/srep45473.

PMID
28378780
Full Text

Nezu, Masahiro, Tomokazu Souma, Lei Yu, Takafumi Suzuki, Daisuke Saigusa, Sadayoshi Ito, Norio Suzuki, and Masayuki Yamamoto. “Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.” Kidney Int 91, no. 2 (February 2017): 387–401. https://doi.org/10.1016/j.kint.2016.08.023.

PMID
27789056
Full Text

Siggs, Owen, Tomokazu Souma, Stuart Tompson, Benjamin Thomson, Luba Kalaydjieva, Dimitar Azmanov, Shahrbanou Javadiyan, et al. “MUTATION OF THE ANGIOPOIETIN RECEPTOR TEK IS ASSOCIATED WITH PRIMARY CONGENITAL GLAUCOMA.” In Clinical and Experimental Ophthalmology, 44:56–56. WILEY-BLACKWELL, 2016.

Scholars@Duke

Liu, Pan, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, and Jing Jin. “A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.” Transplant Direct 2, no. 11 (November 2016): e109. https://doi.org/10.1097/TXD.0000000000000619.

PMID
27826602
Full Text

Thomson, Benjamin R., Isabel Carota, Tomokazu Souma, Krish Kizhatil, Liang Feng, Xiaorong Liu, Simon W. John, Terri L. Young, and Susan E. Quaggin. “Defects in Angiopoietin-Tie2 signaling lead to dose-dependent glaucoma in mice.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Tompson, Stuart W. J., Tomokazu Souma, Owen M. Siggs, Sebastian Maurer-Stroh, Kristina N. Whisenhunt, Ianey L. Wiggs, Francesca Pasutto, Jamie E. Craig, Susan E. Quaggin, and Terri L. Young. “Mutations in a new gene cause glaucoma with variable onset.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

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