Tomokazu Souma, MD, PhD

Medical Instructor in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Email address tomokazu.souma@duke.edu

Education and Training

  • Post-doctoral Fellowship, Feinberg Cardiovascular Research Institute, Northwestern University, 2013 - 2014
  • Post-doctoral Fellowship, Department Of Medical Biochemistry, Tohoku University (Japan), 2012 - 2013
  • Ph.D., Tohoku University (Japan), 2012
  • M.D., Shimane University, 2004

Publications

Liu, Pan, Jan Wysocki, Peter Serfozo, Minghao Ye, Tomokazu Souma, Daniel Batlle, and Jing Jin. “A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13..” Sci Rep 7 (April 5, 2017). https://doi.org/10.1038/srep45473.

PMID
28378780
Full Text

Nezu, Masahiro, Tomokazu Souma, Lei Yu, Takafumi Suzuki, Daisuke Saigusa, Sadayoshi Ito, Norio Suzuki, and Masayuki Yamamoto. “Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression..” Kidney Int 91, no. 2 (February 2017): 387–401. https://doi.org/10.1016/j.kint.2016.08.023.

PMID
27789056
Full Text

Siggs, Owen, Tomokazu Souma, Stuart Tompson, Benjamin Thomson, Luba Kalaydjieva, Dimitar Azmanov, Shahrbanou Javadiyan, et al. “MUTATION OF THE ANGIOPOIETIN RECEPTOR TEK IS ASSOCIATED WITH PRIMARY CONGENITAL GLAUCOMA.” In Clinical and Experimental Ophthalmology, 44:56–56. WILEY-BLACKWELL, 2016.

Scholars@Duke

Liu, Pan, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, and Jing Jin. “A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays..” Transplant Direct 2, no. 11 (November 2016). https://doi.org/10.1097/TXD.0000000000000619.

PMID
27826602
Full Text

Tompson, Stuart W. J., Tomokazu Souma, Owen M. Siggs, Sebastian Maurer-Stroh, Kristina N. Whisenhunt, Ianey L. Wiggs, Francesca Pasutto, Jamie E. Craig, Susan E. Quaggin, and Terri L. Young. “Mutations in a new gene cause glaucoma with variable onset.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Nezu, Masahiro, Tomokazu Souma, Lei Yu, Hiroki Sekine, Takashi Moriguchi, Nobuyuki Takahashi, Sadayoshi Ito, Norio Suzuki, and Masayuki Yamamoto. “OS 05-05 Nrf2 DEFICIENCY ALLEVIATES PERINATAL COMPLICATIONS IN PREGNANCY-ASSOCIATED HYPERTENSION MICE VIA ENHANCING PLACENTAL ANGIOGENESIS.” In Journal of Hypertension, 34:e59–e59. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1097/01.hjh.0000500005.64305.c1.

Full Text

Thomson, Benjamin R., Isabel Carota, Tomokazu Souma, Krish Kizhatil, Liang Feng, Xiaorong Liu, Simon W. John, Terri L. Young, and Susan E. Quaggin. “Defects in Angiopoietin-Tie2 signaling lead to dose-dependent glaucoma in mice.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.

Scholars@Duke

Souma, Tomokazu, Stuart W. Tompson, Benjamin R. Thomson, Owen M. Siggs, Krishnakumar Kizhatil, Shinji Yamaguchi, Liang Feng, et al. “Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity..” J Clin Invest 126, no. 7 (July 1, 2016): 2575–87. https://doi.org/10.1172/JCI85830.

PMID
27270174
Full Text

Souma, Tomokazu, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, et al. “Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling..” J Am Soc Nephrol 27, no. 2 (February 2016): 428–38. https://doi.org/10.1681/ASN.2014121184.

PMID
26054543
Full Text

Tojo, Yutaka, Hiroki Sekine, Ikuo Hirano, Xiaoqing Pan, Tomokazu Souma, Tadayuki Tsujita, Shin-ichi Kawaguchi, et al. “Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes..” Mol Cell Biol 35, no. 15 (August 2015): 2658–72. https://doi.org/10.1128/MCB.00161-15.

PMID
26012551
Full Text

Pages