Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982


Attur, M., S. Ma, J. Samuels, S. Krasnokutsky Samuels, H. Zhou, J. T. Bencardino, M. C. Hochberg, et al. “Functional genetic polymorphism of IL-1rn encoding the IL-1 receptor antagonist predicts radiographic severity of symptomatic knee OA.” In Osteoarthritis and Cartilage, 25:S210–11. Elsevier BV, 2017.

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Huang, Z. Y., and V. B. Kraus. “Reply to Stausholm et al.'s letter to the editor regarding our published study entitled, "Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis"..” Osteoarthritis Cartilage 25, no. 4 (April 2017): e11–14.

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Hsueh, M. -. F., Y. Lu, L. Wheeler, S. S. Wellman, M. P. Bolognesi, and V. B. Kraus. “Functional folate receptor cells within synovium and fluid as therapeutic targets for osteoarthritis.” In Osteoarthritis and Cartilage, 25:S42–43. Elsevier BV, 2017.

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Goode, A. P., R. J. Cleveland, T. A. Schwartz, A. E. Nelson, V. B. Kraus, H. J. Hillstrom, M. T. Hannan, et al. “Relationship of joint hypermobility with low back pain and lumbar spine osteoarthritis: a pooled analysis of three cross-sectional studies.” In Osteoarthritis and Cartilage, 25:S190–91. Elsevier BV, 2017.

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Flowers, P., R. J. Cleveland, T. A. Schwartz, A. E. Nelson, V. B. Kraus, H. J. Hillstrom, A. P. Goode, et al. “Association of joint hypermobility and lower body osteoarthritis by race.” In Osteoarthritis and Cartilage, 25:S197–98. Elsevier BV, 2017.

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Huebner, J. L., B. D. Furman, K. A. Kimmerling, S. A. Olson, F. Guilak, and V. B. Kraus. “Identification of biomarkers indicative of synovitis in the mouse articular fracture model of PTA.” In Osteoarthritis and Cartilage, 25:S104–S104. Elsevier BV, 2017.

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Furman, B. D., K. A. Kimmerling, S. Ramamoorthy, Y. -. J. Li, Y. -. H. Wu, J. L. Huebner, F. Guilak, V. B. Kraus, and S. A. Olson. “Articular fracture upregulates lipid metabolites in human synovial fluid.” In Osteoarthritis and Cartilage, 25:S381–S381. Elsevier BV, 2017.

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Conaghan, P., V. Strand, D. Hunter, V. B. Kraus, F. Berenbaum, N. P. Katz, J. Lufkin, J. R. Johnson, S. Kelley, and N. Bodick. “An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis: post-hoc pooled analyses of 3 randomized controlled trials.” In Osteoarthritis and Cartilage, 25:S432–33. Elsevier BV, 2017.

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Lattermann, Christian, Cale A. Jacobs, Mary Proffitt Bunnell, Kate N. Jochimsen, John P. Abt, Emily K. Reinke, Lee G. Gammon, Janet L. Huebner, Virginia B. Kraus, and Kurt P. Spindler. “Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis..” J Orthop Res 35, no. 3 (March 2017): 641–50.

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AbouAssi, Hiba, Margery A. Connelly, Lori A. Bateman, K Noelle Tune, Janet L. Huebner, Virginia B. Kraus, Deborah A. Winegar, James D. Otvos, William E. Kraus, and Kim M. Huffman. “Does a lack of physical activity explain the rheumatoid arthritis lipid profile?.” Lipids Health Dis 16, no. 1 (February 10, 2017).

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