Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Lattermann, Christian, Cale A. Jacobs, Mary Proffitt Bunnell, Laura J. Huston, Lee G. Gammon, Darren L. Johnson, Emily K. Reinke, Janet L. Huebner, Virginia B. Kraus, and Kurt P. Spindler. “A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear..” Am J Sports Med 45, no. 2 (February 2017): 325–33. https://doi.org/10.1177/0363546516666818.

PMID
28146402
Full Text

Huffman, Kim M., Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, et al. “Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability..” Arthritis Research & Therapy 19, no. 1 (January 23, 2017). https://doi.org/10.1186/s13075-016-1215-7.

PMID
28114971
Full Text

Kraus, Virginia B., David E. Hargrove, David J. Hunter, Jordan B. Renner, and Joanne M. Jordan. “Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium..” In Ann Rheum Dis, 76:179–85, 2017. https://doi.org/10.1136/annrheumdis-2016-209253.

PMID
27343253
Full Text

Kraus, Virginia Byers, Jamie E. Collins, David Hargrove, Elena Losina, Michael Nevitt, Jeffrey N. Katz, Susanne X. Wang, et al. “Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium..” Ann Rheum Dis 76, no. 1 (January 2017): 186–95. https://doi.org/10.1136/annrheumdis-2016-209252.

PMID
27296323
Full Text

Stabler, T. V., Z. Huang, E. Montell, J. Vergés, and V. B. Kraus. “Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules..” Osteoarthritis Cartilage 25, no. 1 (January 2017): 166–74. https://doi.org/10.1016/j.joca.2016.08.012.

PMID
27614315
Full Text

Taylor, Adam M., Ming-Feng Hsueh, Lakshminarayan R. Ranganath, James A. Gallagher, Jane P. Dillon, Janet L. Huebner, Jon B. Catterall, and Virginia B. Kraus. “Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing..” Rheumatology (Oxford) 56, no. 1 (January 2017): 156–64. https://doi.org/10.1093/rheumatology/kew355.

PMID
28028161
Full Text

Gupta, Divakar, Joanne C. Wen, Janet L. Huebner, Sandra Stinnett, Virginia B. Kraus, Henry C. Tseng, and Molly Walsh. “Cytokine biomarkers in tear film for primary open-angle glaucoma..” Clin Ophthalmol 11 (2017): 411–16. https://doi.org/10.2147/OPTH.S125364.

PMID
28260854
Full Text

Yin, Z., Z. Fei, C. Qiu, M. S. Brasher, V. B. Kraus, W. Zhao, X. Shi, and Y. Zeng. “Dietary Diversity and Cognitive Function among Elderly People: A Population-Based Study..” J Nutr Health Aging 21, no. 10 (2017): 1089–94. https://doi.org/10.1007/s12603-017-0912-5.

PMID
29188865
Full Text

Stabler, Thomas V., Eulàlia Montell, Josep Vergés, Janet L. Huebner, and Virginia Byers Kraus. “Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?.” Biomark Insights 12 (2017). https://doi.org/10.1177/1177271917726964.

PMID
28890654
Full Text

Daghestani, Hikmat N., Joanne M. Jordan, Jordan B. Renner, Michael Doherty, A Gerry Wilson, and Virginia B. Kraus. “Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden..” Plos One 12, no. 12 (2017). https://doi.org/10.1371/journal.pone.0190251.

PMID
29287118
Full Text

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