Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Kraus, Virginia Byers, Sheng Feng, ShengChu Wang, Scott White, Maureen Ainslie, Alan Brett, Anthony Holmes, and H Cecil Charles. “Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression..” Arthritis Rheum 60, no. 12 (December 2009): 3711–22. https://doi.org/10.1002/art.25012.

PMID
19950282
Full Text

Sims, Ershela L., Francis J. Keefe, Virginia B. Kraus, Farshid Guilak, Robin M. Queen, and Daniel Schmitt. “Racial differences in gait mechanics associated with knee osteoarthritis..” Aging Clin Exp Res 21, no. 6 (December 2009): 463–69.

PMID
20154517
Scholars@Duke

Kraus, V. B., G. McDaniel, T. W. Worrell, S. Feng, T. P. Vail, G. Varju, and R. E. Coleman. “Association of bone scintigraphic abnormalities with knee malalignment and pain..” Ann Rheum Dis 68, no. 11 (November 2009): 1673–79. https://doi.org/10.1136/ard.2008.094722.

PMID
18981032
Full Text

Addison, Shelby, R Edward Coleman, Sheng Feng, Gary McDaniel, and Virginia Byers Kraus. “Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation..” Arthritis Rheum 60, no. 11 (November 2009): 3366–73. https://doi.org/10.1002/art.24856.

PMID
19877068
Full Text

Nebel, Mary Beth, Ershela L. Sims, Francis J. Keefe, Virginia B. Kraus, Farshid Guilak, David S. Caldwell, Jennifer J. Pells, Robin Queen, and Daniel Schmitt. “The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis..” Arch Phys Med Rehabil 90, no. 11 (November 2009): 1874–79. https://doi.org/10.1016/j.apmr.2009.07.010.

PMID
19887211
Full Text

Griffin, Timothy M., Janet L. Huebner, Virginia B. Kraus, and Farshid Guilak. “Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis..” Arthritis Rheum 60, no. 10 (October 2009): 2935–44. https://doi.org/10.1002/art.24854.

PMID
19790050
Full Text

Allen, Kyle D., Timothy M. Griffin, Ramona M. Rodriguiz, William C. Wetsel, Virginia B. Kraus, Janet L. Huebner, Lawrence M. Boyd, and Lori A. Setton. “Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen..” Arthritis Rheum 60, no. 9 (September 2009): 2684–93. https://doi.org/10.1002/art.24783.

PMID
19714629
Full Text

Hellio Le Graverand, M. -. P., R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, et al. “Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis..” Osteoarthritis Cartilage 17, no. 9 (September 2009): 1177–85. https://doi.org/10.1016/j.joca.2009.03.008.

PMID
19341831
Full Text

Maksymowych, Walter P., Oliver Fitzgerald, George A. Wells, Dafna D. Gladman, Robert Landewe, Mikkel Ostergaard, William J. Taylor, et al. “Proposal for Levels of Evidence Schema for Validation of a Soluble Biomarker Reflecting Damage Endpoints in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis, and Recommendations for Study Design.” In Journal of Rheumatology, 36:1792–99. J RHEUMATOL PUBL CO, 2009. https://doi.org/10.3899/jrheum.090347.

Full Text

Maksymowych, Walter P., Robert Landewé, Paul-Peter Tak, Christopher J. Ritchlin, Mikkel Ostergaard, Philip J. Mease, Hani El-Gabalawy, et al. “Reappraisal of OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage endpoints in rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: the OMERACT 9 v2 criteria..” J Rheumatol 36, no. 8 (August 2009): 1785–91. https://doi.org/10.3899/jrheum.090346.

PMID
19671813
Full Text

Pages