Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Huebner, J. L., K. A. Johnson, V. B. Kraus, and R. A. Terkeltaub. “Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA..” Osteoarthritis Cartilage 17, no. 8 (August 2009): 1056–64. https://doi.org/10.1016/j.joca.2009.02.015.

PMID
19328881
Full Text

Maksymowych, Walter P., Oliver Fitzgerald, George A. Wells, Dafna D. Gladman, Robert Landewé, Mikkel Ostergaard, William J. Taylor, et al. “Proposal for levels of evidence schema for validation of a soluble biomarker reflecting damage endpoints in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and recommendations for study design..” J Rheumatol 36, no. 8 (August 2009): 1792–99. https://doi.org/10.3899/jrheum090347.

PMID
19671814
Full Text

Syversen, Silje W., Robert Landewe, Désirée van der Heijde, Joan M. Bathon, Maarten Boers, Vivian P. Bykerk, Oliver Fitzgerald, et al. “Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers..” J Rheumatol 36, no. 8 (August 2009): 1769–84. https://doi.org/10.3899/jrheum.090262.

PMID
19671812
Full Text

Nelson, A. E., F. Fang, X. A. Shi, V. B. Kraus, T. Stabler, J. B. Renner, T. A. Schwartz, C. G. Helmick, and J. M. Jordan. “Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project..” Osteoarthritis Cartilage 17, no. 6 (June 2009): 772–76. https://doi.org/10.1016/j.joca.2008.11.010.

PMID
19091605
Full Text

Cibere, Jolanda, Hongbin Zhang, Patrick Garnero, A Robin Poole, Tatiana Lobanok, Tore Saxne, Virginia B. Kraus, et al. “Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study..” Arthritis Rheum 60, no. 5 (May 2009): 1372–80. https://doi.org/10.1002/art.24473.

PMID
19404937
Full Text

Somers, Tamara J., Francis J. Keefe, Jennifer J. Pells, Kim E. Dixon, Sandra J. Waters, Paul A. Riordan, James A. Blumenthal, et al. “Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability..” J Pain Symptom Manage 37, no. 5 (May 2009): 863–72. https://doi.org/10.1016/j.jpainsymman.2008.05.009.

PMID
19041218
Full Text

Shamji, Mohammed F., Kyle D. Allen, Stephen So, Liufang Jing, Samuel B. Adams, Reinhard Schuh, Janet Huebner, et al. “Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy..” Spine (Phila Pa 1976) 34, no. 7 (April 1, 2009): 648–54. https://doi.org/10.1097/BRS.0b013e318197f013.

PMID
19333095
Full Text

Couchman, J., V. Kraus, A. Boyde, N. Baker, E. Barr, S. Lohmander, D. Salter, et al. “Past, present and future insights into the understanding and treatment of osteoarthritis: Molecular and mechanical approaches.” International Journal of Experimental Pathology 90, no. 1 (February 1, 2009). https://doi.org/10.1111/j.1365-2613.2008.00612.x.

Full Text

Kraus, Virginia Byers. “Biomarkers and biomarker patterns: new and emerging trends to distinguish osteoarthritis disease subsets and progression.” International Journal of Experimental Pathology 90, no. 1 (February 1, 2009): A45–46.

Scholars@Duke

Sims, Ershela L., Julie M. Carland, Francis J. Keefe, Virginia B. Kraus, Farshid Guilak, and Daniel Schmitt. “Sex differences in biomechanics associated with knee osteoarthritis..” J Women Aging 21, no. 3 (2009): 159–70. https://doi.org/10.1080/08952840903054856.

PMID
20183142
Full Text

Pages