Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982



Allen, K. D., J. M. Jordan, J. B. Renner, and V. B. Kraus. “Relationship of global assessment of change to AUSCAN and pinch and grip strength among individuals with hand osteoarthritis..” Osteoarthritis Cartilage 14, no. 12 (December 2006): 1281–87.

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Betre, Helawe, Wenge Liu, Michael R. Zalutsky, Ashutosh Chilkoti, Virginia B. Kraus, and Lori A. Setton. “A thermally responsive biopolymer for intra-articular drug delivery..” J Control Release 115, no. 2 (October 10, 2006): 175–82.

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Allen, Kelli D., Robert F. DeVellis, Jordan B. Renner, Virginia B. Kraus, and Joanne M. Jordan. “Validity and factor structure of the AUSCAN osteoarthritis hand index in an African American and white community sample..” In Arthritis and Rheumatism, 54:S150–S150. WILEY-LISS, 2006.


Kong, S. Y., T. V. Stabler, L. G. Criscione, A. L. Elliott, J. M. Jordan, and V. B. Kraus. “Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis..” Arthritis Rheum 54, no. 8 (August 2006): 2496–2504.

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Bauer, D. C., D. J. Hunter, S. B. Abramson, M. Attur, M. Corr, D. Felson, D. Heinegård, et al. “Classification of osteoarthritis biomarkers: a proposed approach..” Osteoarthritis Cartilage 14, no. 8 (August 2006): 723–27.

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McCudden, C. R., and V. B. Kraus. “Protein racemization as a biomarker of osteoarthritis.” In Clinical Chemistry, 52:A159–A159. AMER ASSOC CLINICAL CHEMISTRY, 2006.


Allen, Kelli D., Joanne M. Jordan, Jordan B. Renner, and Virginia B. Kraus. “Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index..” Arthritis Rheum 54, no. 2 (February 2006): 551–56.

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