Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

McCudden, C. R., and V. B. Kraus. “Protein racemization as a biomarker of osteoarthritis.” In Clinical Chemistry, 52:A159–A159. AMER ASSOC CLINICAL CHEMISTRY, 2006.

Scholars@Duke

Allen, Kelli D., Joanne M. Jordan, Jordan B. Renner, and Virginia B. Kraus. “Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index..” Arthritis Rheum 54, no. 2 (February 2006): 551–56. https://doi.org/10.1002/art.21615.

PMID
16447231
Full Text

Piscoya, J. L., B. Fermor, V. B. Kraus, T. V. Stabler, and F. Guilak. “The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants..” Osteoarthritis Cartilage 13, no. 12 (December 2005): 1092–99. https://doi.org/10.1016/j.joca.2005.07.003.

PMID
16168680
Full Text

Eckstein, Felix, H Cecil Charles, Robert J. Buck, Virginia B. Kraus, Ann E. Remmers, Martin Hudelmaier, Wolfgang Wirth, and Jeffrey L. Evelhoch. “Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T..” Arthritis Rheum 52, no. 10 (October 2005): 3132–36. https://doi.org/10.1002/art.21348.

PMID
16200592
Full Text

Kraus, Virginia Byers. “Biomarkers in osteoarthritis..” Curr Opin Rheumatol 17, no. 5 (September 2005): 641–46.

PMID
16093846
Scholars@Duke

Criscione, Lisa G., Alan L. Elliott, Thomas Stabler, Joanne M. Jordan, Carl F. Pieper, and Virginia B. Kraus. “Variation of serum hyaluronan with activity in individuals with knee osteoarthritis..” Osteoarthritis Cartilage 13, no. 9 (September 2005): 837–40. https://doi.org/10.1016/j.joca.2005.05.004.

PMID
16153551
Full Text

Lamers, R. J. A. N., J. H. J. van Nesselrooij, V. B. Kraus, J. M. Jordan, J. B. Renner, A. D. Dragomir, G. Luta, J. van der Greef, and J. DeGroot. “Identification of an urinary metabolite profile associated with osteoarthritis..” Osteoarthritis Cartilage 13, no. 9 (September 2005): 762–68. https://doi.org/10.1016/j.joca.2005.04.005.

PMID
15951202
Full Text

McNulty, Amy L., Thomas V. Stabler, Thomas P. Vail, Gary E. McDaniel, and Virginia B. Kraus. “Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint..” Arthritis Rheum 52, no. 9 (September 2005): 2676–85. https://doi.org/10.1002/art.21254.

PMID
16142743
Full Text

Elliott, A. L., F. Fang, V. B. Kraus, J. B. Renner, C. Helmick, M. C. Hochberg, and J. M. Jordan. “Association of symptoms and signs of hand osteoarthritis with hip and knee osteoarthritis in African-Americans and Caucasians..” In Arthritis and Rheumatism, 52:S515–S515. WILEY-BLACKWELL, 2005.

Scholars@Duke

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