Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Dragomir, A. D., J. M. Jordan, V. B. Kraus, G. Luta, J. B. Renner, and A. R. Poole. “Altered levels of serum cartilage markers in postmenopausal African-American and caucasian women on current hormone replacement therapy.” In Osteoarthritis and Cartilage, 12:S54–55. W B SAUNDERS CO LTD, 2004.

Scholars@Duke

Kraus, Virginia B., Thomas Stabler, Elizabeth T. Le, Mary Saltarelli, and Nancy B. Allen. “Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis..” Arthritis Rheum 48, no. 10 (October 2003): 2942–48. https://doi.org/10.1002/art.11281.

PMID
14558101
Full Text

Dragomir, A. D., V. B. Kraus, G. Luta, T. Stabler, J. B. Renner, C. G. Helmick, M. C. Hochberg, and J. M. Jordan. “Lower levels of 2 putative biomarkers of osteoarthritis (OA) in postmenopausal African American and Caucasian women on current hormone replacement therapy.” In Arthritis and Rheumatism, 48:S211–S211. WILEY-LISS, 2003.

Scholars@Duke

Jordan, J. M., V. B. Kraus, J. B. Renner, G. Luta, A. D. Dragomir, T. Stabler, V. Vilim, M. C. Hochberg, and C. G. Helmick. “Associations between medical co-morbidities and putative biomarkers of osteoarthritis (OA).” In Arthritis and Rheumatism, 48:S213–S213. WILEY-LISS, 2003.

Scholars@Duke

Stabler, Thomas V., and Virginia B. Kraus. “Ascorbic acid accumulates in cartilage in vivo..” Clin Chim Acta 334, no. 1–2 (August 2003): 157–62. https://doi.org/10.1016/s0009-8981(03)00225-0.

PMID
12867287
Full Text

Stabler, T. V., J. M. Jordan, V. B. Kraus, G. Luta, J. B. Renner, A. D. Dragomir, M. C. Hochberg, and C. G. Helmick. “Serum C-reactive protein (CRP) levels and osteoarthritis.” In Clinical Chemistry, 49:A53–A53. AMER ASSOC CLINICAL CHEMISTRY, 2003.

Scholars@Duke

Lamers, Robert-Jan A. N., Jeroen DeGroot, Elly J. Spies-Faber, Renger H. Jellema, Virginia B. Kraus, Nicole Verzijl, Johan M. TeKoppele, et al. “Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic Guinea pigs..” J Nutr 133, no. 6 (June 2003): 1776–80. https://doi.org/10.1093/jn/133.6.1776.

PMID
12771316
Full Text

Kraus, Virginia Byers. “Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis..” Foot Ankle Clin 8, no. 2 (June 2003): 187–vii.

PMID
12911235
Scholars@Duke

Jordan, Joanne M., Gheorghe Luta, Thomas Stabler, Jordan B. Renner, Anca D. Dragomir, Vladimir Vilim, Marc C. Hochberg, Charles G. Helmick, and Virginia B. Kraus. “Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project..” Arthritis Rheum 48, no. 3 (March 2003): 675–81. https://doi.org/10.1002/art.10822.

PMID
12632420
Full Text

Vilím, Vladimír, Zdenek Vobůrka, Richard Vytásek, Ladislav Senolt, Ilja Tchetverikov, Virginia B. Kraus, and Karel Pavelka. “Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA..” Clin Chim Acta 328, no. 1–2 (February 2003): 59–69. https://doi.org/10.1016/s0009-8981(02)00375-3.

PMID
12559599
Full Text

Pages