Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Clark, A. G., J. M. Jordan, V. Vilim, J. B. Renner, A. D. Dragomir, G. Luta, and V. B. Kraus. “Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project..” Arthritis Rheum 42, no. 11 (November 1999): 2356–64. https://doi.org/10.1002/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R.

PMID
10555031
Full Text

Selman, M., and A. Pardo. “Expression of matrix metalloproteinase 1 in rodents: comment on the article by Huebner et al..” Arthritis Rheum 42, no. 3 (March 1999). https://doi.org/10.1002/1529-0131(199904)42:3<590::AID-ANR35>3.0.CO;2-F.

PMID
10088792
Full Text

Huebner, J. L., I. G. Otterness, E. M. Freund, B. Caterson, and V. B. Kraus. “Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis..” Arthritis Rheum 41, no. 5 (May 1998): 877–90. https://doi.org/10.1002/1529-0131(199805)41:5<877::AID-ART16>3.0.CO;2-#.

PMID
9588741
Full Text

Bello, A. E., W. E. Garrett, H. Wang, J. Lohnes, E. DeLong, B. Caterson, and V. B. Kraus. “Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury..” Osteoarthritis Cartilage 5, no. 6 (November 1997): 419–26.

PMID
9536290
Scholars@Duke

Kraus, V. B., E. M. N. Freund, J. L. Huebner, and B. Caterson. “Collagenase in a guinea PK3 model of natural osteoarthrftis.” Journal of Investigative Medicine 44, no. 3 (January 1, 1996).

Scholars@Duke

Kraus, V. B., J. A. Inostroza, K. Yeung, D. Reinberg, and J. R. Nevins. “Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A..” Proc Natl Acad Sci U S A 91, no. 14 (July 5, 1994): 6279–82. https://doi.org/10.1073/pnas.91.14.6279.

PMID
8022773
Full Text

Taylor, D. A., V. B. Kraus, J. J. Schwarz, E. N. Olson, and W. E. Kraus. “E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins..” Mol Cell Biol 13, no. 8 (August 1993): 4714–27. https://doi.org/10.1128/mcb.13.8.4714.

PMID
8393137
Full Text

TAYLOR, D. A., V. B. KRAUS, J. J. SCHWARZ, E. N. OLSON, and W. E. KRAUS. “E1A-MEDIATED INHIBITION OF MYOGENESIS - A DIRECT PHYSICAL INTERACTION OF E1A(12S) AND BHLH PROTEINS.” Journal of Cellular Biochemistry, March 13, 1993, 225–225.

Scholars@Duke

Pages