Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982


Goode, Adam P., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Marian T. Hannan, et al. “Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.” Bmc Musculoskelet Disord 20, no. 1 (April 9, 2019): 158.

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Parker, D. C., D. W. Belsky, and V. B. Kraus. “Quantifications of biological aging predict disability and mortality in older adults in the Duke EPESE.” In Journal of the American Geriatrics Society, 67:S145–S145. WILEY, 2019.


Golightly, Yvonne M., Marian T. Hannan, Amanda E. Nelson, Howard J. Hillstrom, Rebecca J. Cleveland, Virginia B. Kraus, Todd A. Schwartz, et al. “Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort.” Arthritis Care Res (Hoboken) 71, no. 4 (April 2019): 538–44.

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Kraus, V. B., L. S. Simon, J. N. Katz, T. Neogi, D. Hunter, A. Guermazi, and M. A. Karsdal. “Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs.” Osteoarthritis Cartilage 27, no. 4 (April 2019): 571–79.

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Lv, Yue-Bin, Chen Mao, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jin-Qiu Yuan, Juan Zhang, Jie-Si Luo, Yi Zeng, and Xiao-Ming Shi. “Triglycerides Paradox Among the Oldest Old: "The Lower the Better?".” J Am Geriatr Soc 67, no. 4 (April 2019): 741–48.

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Gomoll, A., A. Spitzer, J. C. Richmond, V. B. Kraus, D. G. Jones, K. M. Huffman, A. Cinar, J. Lufkin, and S. Kelley. “Repeat administration of triamcinolone acetonide extended-release affords consistent, clinically relevant improvements in pain: results from a phase 3B, single-arm, open-label study.” In Osteoarthritis and Cartilage, 27:S505–6. Elsevier BV, 2019.

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Chou, C. -. H., J. Gibson, D. E. Attarian, C. Haraden, C. B. Yohn, R. -. M. Laberge, S. Gregory, and V. B. Kraus. “Profiling human chondrocytes and synoviocytes using single cell RNA sequencing identifies cell diversity in the pathogenesis of osteoarthritis in the joint organ.” In Osteoarthritis and Cartilage, 27:S27–S27. Elsevier BV, 2019.

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Hsueh, M. -. F., P. Onnerfjord, M. P. Bolognesi, M. E. Easley, and V. B. Kraus. “microRNAs and cartilage matrix protein turnover responded collectively to the stress of osteoarthritis.” In Osteoarthritis and Cartilage, 27:S59–S59. Elsevier BV, 2019.

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