Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Furman, Bridgette D., Collin L. Kent, Janet L. Huebner, Virginia B. Kraus, Amy L. McNulty, Farshid Guilak, and Steven A. Olson. “CXCL10 is upregulated in synovium and cartilage following articular fracture..” J Orthop Res 36, no. 4 (April 2018): 1220–27. https://doi.org/10.1002/jor.23735.

PMID
28906016
Full Text

Amano, Keiko, Janet L. Huebner, Thomas V. Stabler, Matthew Tanaka, Charles E. McCulloch, Iryna Lobach, Nancy E. Lane, Virginia B. Kraus, C Benjamin Ma, and Xiaojuan Li. “Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery..” Am J Sports Med 46, no. 4 (March 2018): 890–99. https://doi.org/10.1177/0363546517749834.

PMID
29364702
Full Text

McIlwraith, C Wayne, Christopher E. Kawcak, David D. Frisbie, Christopher B. Little, Peter D. Clegg, Mandy J. Peffers, Morten A. Karsdal, et al. “Biomarkers for equine joint injury and osteoarthritis..” J Orthop Res 36, no. 3 (March 2018): 823–31. https://doi.org/10.1002/jor.23738.

PMID
28921609
Full Text

ZeYu Huang, Yong Nie, Bin Xu, Bin Shen, Virginia B. Kraus, and FuXing Pei. “Evidence and mechanism by which upper partial fibulectomy improves knee biomechanics and decreases knee pain of osteoarthritis..” J Orthop Res, February 9, 2018. https://doi.org/10.1002/jor.23867.

PMID
29424452
Full Text

Chou, C. -. H., D. E. Attarian, H. -. G. Wisniewski, P. A. Band, and V. B. Kraus. “TSG-6 - a double-edged sword for osteoarthritis (OA)..” In Osteoarthritis Cartilage, 26:245–54, 2018. https://doi.org/10.1016/j.joca.2017.10.019.

PMID
29129649
Full Text

Luyten, F. P., S. Bierma-Zeinstra, F. Dell’Accio, V. B. Kraus, K. Nakata, I. Sekiya, N. K. Arden, and L. S. Lohmander. “Toward classification criteria for early osteoarthritis of the knee..” Semin Arthritis Rheum 47, no. 4 (February 2018): 457–63. https://doi.org/10.1016/j.semarthrit.2017.08.006.

PMID
28917712
Full Text

Nie, Yong, HaoYang Wang, ZeYu Huang, Bin Shen, Virginia Byers Kraus, and Zongke Zhou. “Radiographic Underestimation of In Vivo Cup Coverage Provided by Total Hip Arthroplasty for Dysplasia..” Orthopedics 41, no. 1 (January 1, 2018): e46–51. https://doi.org/10.3928/01477447-20171114-01.

PMID
29156073
Full Text

Kraus, V. B., P. G. Conaghan, H. A. Aazami, P. Mehra, A. J. Kivitz, J. Lufkin, J. Hauben, J. R. Johnson, and N. Bodick. “Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)..” In Osteoarthritis Cartilage, 26:34–42, 2018. https://doi.org/10.1016/j.joca.2017.10.003.

PMID
29024802
Full Text

Kraus, Virginia Byers, Jamie E. Collins, H Cecil Charles, Carl F. Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, et al. “Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium..” Arthritis Rheumatol 70, no. 1 (January 2018): 80–87. https://doi.org/10.1002/art.40348.

PMID
29024470
Full Text

Lattermann, Christian, Caitlin E-W Conley, Darren L. Johnson, Emily K. Reinke, Laura J. Huston, Janet L. Huebner, Ching-Heng Chou, Virginia B. Kraus, Kurt P. Spindler, and Cale A. Jacobs. “Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study..” Biomed Res Int 2018 (2018). https://doi.org/10.1155/2018/9387809.

PMID
30105266
Full Text

Pages