Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982


Leung, Y, Wong, B, Haaland, B, and Kraus, V. "Association between radiographic severity and pain in knee osteoarthritis." April 2016.

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Nwosu, L, Chapman, V, Walsh, D, and Kraus, V. "Subchondral bone biomarkers as predictors of OA pain progression; linking structural pathology and pain." April 2016.

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Stabler, T, Montell, E, Vergés, J, and Kraus, V. "Chondroitin sulphate inhibition of NF-κB activity: attentuation of hyaluronan fragment induced inflammatory response in macrophages by chondroitin sulphate is mediated by reduction in NF-κB activity." April 2016.

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Kraus, V, Catterall, J, Soderblom, E, Moseley, M, and Suchindran, S. "Development of a serum biomarker panel highly predictive of knee osteoarthritis progression." April 2016.

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Chou, C-H, Wisniewski, H-G, Band, P, Huebner, J, Stabler, T, Lattermann, C, and Kraus, V. "TSG-6 Activity reflects severity of inflammation in knee osteoarthritis and acute joint injury." April 2016.

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Kraus, V, Martinez, H, Herrero, M, and Verges, J. "A proteomic panel predicts drug response to the combination of glucosamine and chondroitin sulfate." April 2016.

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Leung, Y, Huebner, J, Wong, B, and Kraus, V. "Association of synovial fluid inflammatory biomarkers and knee pain." April 2016.

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Lv, YB, Yin, ZX, Chei, CL, Brasher, MS, Zhang, J, Kraus, VB, Qian, F, Shi, X, Matchar, DB, and Zeng, Y. "Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly." Journal of Nutrition, Health and Aging 20, no. 3 (March 1, 2016): 280-287.

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Bowles, RD, Karikari, IO, VanDerwerken, DN, Sinclair, MS, Bell, RD, Riebe, KJ, Huebner, JL, Kraus, VB, Sempowski, GD, and Setton, LA. "In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy." European journal of pain (London, England) 20, no. 3 (March 2016): 365-376.

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Lv, Y-B, Yin, ZX, Chei, C-L, Brasher, MS, Zhang, J, Kraus, VB, Qian, F, Shi, X-M, Matchar, DB, and Zeng, Y. "Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly." The journal of nutrition, health & aging 20, no. 3 (March 2016): 280-287.

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