Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Lattermann, C, Jacobs, CA, Proffitt Bunnell, M, Huston, LJ, Gammon, LG, Johnson, DL, Reinke, EK, Huebner, JL, Kraus, VB, and Spindler, KP. "A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear." The American journal of sports medicine 45, no. 2 (February 2017): 325-333.

PMID
28146402
Full Text

Lv, Y-B, Zhu, P-F, Yin, Z-X, Kraus, VB, Threapleton, D, Chei, C-L, Brasher, MS, Zhang, J, Qian, H-Z, Mao, C, Matchar, DB, Luo, J-S, Zeng, Y, and Shi, X-M. "A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly." Journal of the American Medical Directors Association 18, no. 2 (February 2017): 193.e7-193.e13.

PMID
28126139
Full Text

Huffman, KM, Jessee, R, Andonian, B, Davis, BN, Narowski, R, Huebner, JL, Kraus, VB, McCracken, J, Gilmore, BF, Tune, KN, Campbell, M, Koves, TR, Muoio, DM, Hubal, MJ, and Kraus, WE. "Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability." Arthritis research & therapy 19, no. 1 (January 23, 2017): 12-.

PMID
28114971
Full Text

Kraus, VB, Hargrove, DE, Hunter, DJ, Renner, JB, and Jordan, JM. "Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium." January 2017.

PMID
27343253
Full Text

Kraus, VB, Collins, JE, Hargrove, D, Losina, E, Nevitt, M, Katz, JN, Wang, SX, Sandell, LJ, Hoffmann, SC, Hunter, DJ, and OA Biomarkers Consortium, . "Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium." Annals of the rheumatic diseases 76, no. 1 (January 2017): 186-195.

PMID
27296323
Full Text

Stabler, TV, Huang, Z, Montell, E, Vergés, J, and Kraus, VB. "Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules." Osteoarthritis and Cartilage 25, no. 1 (January 2017): 166-174.

PMID
27614315
Full Text

Taylor, AM, Hsueh, M-F, Ranganath, LR, Gallagher, JA, Dillon, JP, Huebner, JL, Catterall, JB, and Kraus, VB. "Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing." Rheumatology (Oxford, England) 56, no. 1 (January 2017): 156-164.

PMID
28028161
Full Text

Kraus, VB, Hargrove, DE, Hunter, DJ, Renner, JB, and Jordan, JM. "Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium." ANNALS OF THE RHEUMATIC DISEASES 76, no. 1 (January 2017): 179-185.

Full Text

Gupta, D, Wen, JC, Huebner, JL, Stinnett, S, Kraus, VB, Tseng, HC, and Walsh, M. "Cytokine biomarkers in tear film for primary open-angle glaucoma." Clinical Ophthalmology (Auckland, N.Z.) 11 (January 2017): 411-416.

PMID
28260854
Full Text

Stabler, TV, Montell, E, Vergés, J, Huebner, JL, and Kraus, VB. "Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?." Biomarker insights 12 (January 2017): 1177271917726964-.

PMID
28890654
Full Text

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