Wei Chen, PhD

Associate Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Duke Box 3256, Durham, NC 27710
Phone (919) 684-4433
Email address w.chen@duke.edu

My general area of interest relates to how cancer develops and how to identify cancer therapeutic agents. In particular I hope to identify molecular signals that underlie the changes necessary for directing normal tissue to a malignant state in cancer. Therefore, I have been studying how extracellular signals are deciphered by seven trans-membrane receptors and their regulatory proteins to control cell proliferation and differentiation. My major research focuses on studying GPCR, Smoothened, TGF-beta and Frizzled receptor trafficking and signaling as well as their roles in tumor biology. Abnormalities in the receptors or other proteins they interact with either directly or indirectly result in malignancies. Moreover, as a result of our research, we have established a state-of-the-art high throughput, high content screening platform in my laboratory to identify novel small molecules that modulate the activity of these receptors. We have found many new small molecules that block Hedgehog pathway. These chemical compounds may have the potential to become new therapeutic agents to treat many refractory cancers of the pancreas, liver, breast, prostate, and skin.

Education and Training

  • Ph.D., University of Toledo, 1999

Publications

Davidson, BA, Rubatt, JM, Corcoran, DL, Teoh, DK, Bernardini, MQ, Grace, LA, Soper, WJ, Berchuck, A, Siamakpour-Reihani, S, Chen, W, Owzar, K, Murphy, SK, and Secord, AA. "Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines." Frontiers in oncology 4 (2014): 163-.

PMID
24999452
Full Text

Barak, LS, Bai, Y, Snyder, JC, Wang, J, Chen, W, and Caron, MG. "Triphenylmethane dye activation of beta-arrestin." Biochemistry 52, no. 32 (August 13, 2013): 5403-5414.

PMID
23865508
Full Text

Mook, RA, Chen, M, Lu, J, Barak, LS, Lyerly, HK, and Chen, W. "Small molecule modulators of Wnt/β-catenin signaling." Bioorg Med Chem Lett 23, no. 7 (April 1, 2013): 2187-2191.

PMID
23453073
Full Text

Fang, S, Crews, AL, Chen, W, Park, J, Yin, Q, Ren, X-R, and Adler, KB. "MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304, no. 8 (April 2013): L511-L518.

PMID
23377348
Full Text

Hamilton, E, Blackwell, K, Hobeika, AC, Clay, TM, Broadwater, G, Ren, XR, Chen, W, Castro, H, Lehmann, F, Spector, N, Wei, J, Osada, T, Lyerly, HK, and Morse, MA. "Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion." J Transl Med 11 (2013): 82-.

PMID
23536971
Full Text

Lu, J, Chen, M, Ren, XR, Wang, J, Lyerly, HK, Barak, L, and Chen, W. "Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1." PLoS One 8, no. 5 (2013): e63353-.

PMID
23671675
Full Text

Pan, C, Liu, HD, Gong, Z, Yu, X, Hou, XB, Xie, DD, Zhu, XB, Li, HW, Tang, JY, Xu, YF, Yu, JQ, Zhang, LY, Fang, H, Xiao, KH, Chen, YG, Wang, JY, Pang, Q, Chen, W, and Sun, JP. "Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site." Scientific Reports 3 (2013).

PMID
23903585
Full Text

Wang, J, Mook, RA, Lu, J, Gooden, DM, Ribeiro, A, Guo, A, Barak, LS, Lyerly, HK, and Chen, W. "Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling." Bioorg Med Chem 20, no. 22 (November 15, 2012): 6751-6757.

PMID
23063522
Full Text

Qing-feng, L, Wei, C, and Shu-tian, Z. "Identification of Nedd4 as a novel regulator in Hedgehog signaling." CHINESE MEDICAL JOURNAL 125, no. 21 (November 5, 2012): 3851-3855.

PMID
23106887
Full Text

Wang, J, Lu, J, Mook, RA, Zhang, M, Zhao, S, Barak, LS, Freedman, JH, Lyerly, HK, and Chen, W. "The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks." Toxicol Sci 128, no. 2 (August 2012): 517-523.

PMID
22552772
Full Text

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