Wei Chen, PhD

Associate Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Duke Box 3256, Durham, NC 27710
Phone (919) 684-4433
Email address w.chen@duke.edu

My general area of interest relates to how cancer develops and how to identify cancer therapeutic agents. In particular I hope to identify molecular signals that underlie the changes necessary for directing normal tissue to a malignant state in cancer. Therefore, I have been studying how extracellular signals are deciphered by seven trans-membrane receptors and their regulatory proteins to control cell proliferation and differentiation. My major research focuses on studying GPCR, Smoothened, TGF-beta and Frizzled receptor trafficking and signaling as well as their roles in tumor biology. Abnormalities in the receptors or other proteins they interact with either directly or indirectly result in malignancies. Moreover, as a result of our research, we have established a state-of-the-art high throughput, high content screening platform in my laboratory to identify novel small molecules that modulate the activity of these receptors. We have found many new small molecules that block Hedgehog pathway. These chemical compounds may have the potential to become new therapeutic agents to treat many refractory cancers of the pancreas, liver, breast, prostate, and skin.

Education and Training

  • Ph.D., University of Toledo, 1999

Publications

Ren, XR, Wang, J, Osada, T, Mook, RA, Morse, MA, Barak, LS, Lyerly, HK, and Chen, W. "Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth." Breast cancer research : BCR 17, no. 1 (December 2015): 528-.

PMID
25778364
Scholars@Duke

Chen, M, Hegde, A, Choi, YH, Theriot, BS, Premont, RT, Chen, W, and Walker, JK. "Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model." American journal of respiratory cell and molecular biology 53, no. 3 (September 2015): 346-354.

PMID
25569510
Full Text

Mook, RA, Wang, J, Ren, XR, Chen, M, Spasojevic, I, Barak, LS, Lyerly, HK, and Chen, W. "Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure." Bioorganic & medicinal chemistry 23, no. 17 (September 2015): 5829-5838.

PMID
26272032
Full Text

Horton, JK, Blitzblau, RC, Yoo, S, Geradts, J, Chang, Z, Baker, JA, Georgiade, GS, Chen, W, Siamakpour-Reihani, S, Wang, C, Broadwater, G, Groth, J, Palta, M, Dewhirst, M, Barry, WT, Duffy, EA, Chi, JT, and Hwang, ES. "Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers." International journal of radiation oncology, biology, physics 92, no. 4 (July 2015): 846-855.

PMID
26104938
Full Text

Chen, W, Gao, R, Xie, X, Zheng, Z, Li, H, Li, S, Dong, F, and Wang, L. "A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice." Scientific Reports 5 (May 6, 2015): 9884-9884.

Full Text

Davidson, BA, Rubatt, JM, Corcoran, DL, Teoh, DK, Bernardini, MQ, Grace, LA, Soper, WJ, Berchuck, A, Siamakpour-Reihani, S, Chen, W, Owzar, K, Murphy, SK, and Secord, AA. "Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines." Frontiers in oncology 4 (January 2014): 163-.

PMID
24999452
Full Text

Barak, LS, Bai, Y, Snyder, JC, Wang, J, Chen, W, and Caron, MG. "Triphenylmethane dye activation of beta-arrestin." Biochemistry 52, no. 32 (August 2013): 5403-5414.

PMID
23865508
Full Text

Mook, RA, Chen, M, Lu, J, Barak, LS, Lyerly, HK, and Chen, W. "Small molecule modulators of Wnt/β-catenin signaling." Bioorg Med Chem Lett 23, no. 7 (April 1, 2013): 2187-2191.

PMID
23453073
Full Text

Fang, S, Crews, AL, Chen, W, Park, J, Yin, Q, Ren, X-R, and Adler, KB. "MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304, no. 8 (April 2013): L511-L518.

PMID
23377348
Full Text

Hamilton, E, Blackwell, K, Hobeika, AC, Clay, TM, Broadwater, G, Ren, XR, Chen, W, Castro, H, Lehmann, F, Spector, N, Wei, J, Osada, T, Lyerly, HK, and Morse, MA. "Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion." J Transl Med 11 (2013): 82-.

PMID
23536971
Full Text

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