William Christopher Wetsel, PhD

Associate Professor in Psychiatry and Behavioral Sciences
Associate Professor in Neurobiology
Assistant Research Professor in Cell Biology
Assistant Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 354 Sands Bldg, Durham, NC 27710
Phone (919) 684-4574
Email address william.wetsel@duke.edu

RESEARCH INTERESTS
Last Updated: 31 December 1997

My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the expression of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, an identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The advent of gene manipulation in mice has permitted specific genes to be targeted for disruption, mutation, and/or overexpression in the whole organism or in selected regions or cells in the nervous and other systems. In this way, primary and secondary effects of a given gene manipulation can be related to various neuroendoctine, neurological, or psychiatric conditions in humans. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have neurobehaviorally phenotyped many different lines of inbred and mutant mice for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. Following the development of mouse models, we have worked with various investigators to identify the molecular and cellular basis of the neuroendocrine and/or behavioral abnormalities. We are working also with medicinal chemists and certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in the mutant mice. Some of these preclinical studies are now forming a basis for clinical trials in humans.

Education and Training

  • Ph.D., Massachusetts Institute of Technology, 1983

Publications

Shen, Yudao, John D. McCorvy, Michael L. Martini, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Karen M. Ward, William C. Wetsel, Jing Liu, Bryan L. Roth, and Jian Jin. “D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine..” J Med Chem 62, no. 9 (May 9, 2019): 4755–71. https://doi.org/10.1021/acs.jmedchem.9b00508.

PMID
30964661
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Arbogast, Thomas, Parisa Razaz, Jacob Ellegood, Spencer U. McKinstry, Serkan Erdin, Benjamin Currall, Tanya Aneichyk, et al. “Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions..” Hum Mol Genet 28, no. 9 (May 1, 2019): 1474–86. https://doi.org/10.1093/hmg/ddy436.

PMID
30590535
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Badea, Alexandra, Natalie A. Delpratt, R. J. Anderson, Russell Dibb, Yi Qi, Hongjiang Wei, Chunlei Liu, William C. Wetsel, Brian B. Avants, and Carol Colton. “Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease..” Magnetic Resonance Imaging 60 (March 30, 2019): 52–67. https://doi.org/10.1016/j.mri.2019.03.022.

PMID
30940494
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguiz, Michael D. Kritzer, Angel V. Peterchev, Jeffrey Roach, William C. Wetsel, and Douglas E. Williamson. “Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice..” Scientific Reports 9, no. 1 (March 2019). https://doi.org/10.1038/s41598-019-40140-5.

PMID
30824791
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Huffman, William J., Saraswathi Subramaniyan, Ramona M. Rodriguiz, William C. Wetsel, Warren M. Grill, and Niccolò Terrando. “Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice..” Brain Stimul 12, no. 1 (January 2019): 19–29. https://doi.org/10.1016/j.brs.2018.10.005.

PMID
30337243
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguez, Michael D. Kritzer, Angel V. Peterchev, et al. “Correction: Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing..” Plos One 14, no. 2 (January 2019). https://doi.org/10.1371/journal.pone.0212712.

PMID
30779792
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Helseth, Ashley R., Arsen S. Hunanyan, Syed Adil, Molly Linabarger, Monisha Sachdev, Elie Abdelnour, Eric Arehart, et al. “Novel E815K knock-in mouse model of alternating hemiplegia of childhood..” Neurobiology of Disease 119 (November 2018): 100–112. https://doi.org/10.1016/j.nbd.2018.07.028.

PMID
30071271
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Bey, Alexandra L., Xiaoming Wang, Haidun Yan, Namsoo Kim, Rebecca L. Passman, Yilin Yang, Xinyu Cao, et al. “Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors..” Translational Psychiatry 8, no. 1 (April 27, 2018). https://doi.org/10.1038/s41398-018-0142-6.

PMID
29700290
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Wang, Xiaoting, David A. Gallegos, Vladimir M. Pogorelov, Justin K. O’Hare, Nicole Calakos, William C. Wetsel, and Anne E. West. “Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference..” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 43, no. 5 (April 2018): 953–63. https://doi.org/10.1038/npp.2017.178.

PMID
28840858
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Martyn, Amanda C., Krisztian Toth, Robert Schmalzigaug, Nathan G. Hedrick, Ramona M. Rodriguiz, Ryohei Yasuda, William C. Wetsel, and Richard T. Premont. “GIT1 regulates synaptic structural plasticity underlying learning..” Plos One 13, no. 3 (January 2018). https://doi.org/10.1371/journal.pone.0194350.

PMID
29554125
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