William Christopher Wetsel, PhD

Associate Professor in Psychiatry and Behavioral Sciences
Associate Professor in Neurobiology
Assistant Research Professor in Cell Biology
Assistant Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 354 Sands Bldg, Durham, NC 27710
Phone (919) 684-4574
Email address william.wetsel@duke.edu

RESEARCH INTERESTS
Last Updated: 31 December 1997

My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the expression of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, an identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The advent of gene manipulation in mice has permitted specific genes to be targeted for disruption, mutation, and/or overexpression in the whole organism or in selected regions or cells in the nervous and other systems. In this way, primary and secondary effects of a given gene manipulation can be related to various neuroendoctine, neurological, or psychiatric conditions in humans. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have neurobehaviorally phenotyped many different lines of inbred and mutant mice for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. Following the development of mouse models, we have worked with various investigators to identify the molecular and cellular basis of the neuroendocrine and/or behavioral abnormalities. We are working also with medicinal chemists and certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in the mutant mice. Some of these preclinical studies are now forming a basis for clinical trials in humans.

Education and Training

  • Ph.D., Massachusetts Institute of Technology, 1983

Publications

Martini, Michael L., Caroline Ray, Xufen Yu, Jing Liu, Vladimir M. Pogorelov, William C. Wetsel, Xi-Ping Huang, John D. McCorvy, Marc G. Caron, and Jian Jin. “Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity..” Acs Chem Neurosci 10, no. 9 (September 18, 2019): 4160–82. https://doi.org/10.1021/acschemneuro.9b00410.

PMID
31387346
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Kritzer, M., W. Rosario, J. Tharayil, C. Lai, P. Botros, A. Lowell, D. Cruz, et al. “Erratum to ‘Electroconvulsive stimulation increases astrocyte marker GFAP in mouse hippocampus regardless of chronic social defeat stress’ (Brain Stimulation (2019) 12(2) (543), (S1935861X18312105), (10.1016/j.brs.2018.12.791)).” Brain Stimulation 12, no. 5 (September 1, 2019). https://doi.org/10.1016/j.brs.2019.06.008.

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Yang, Rui, Kathryn K. Walder-Christensen, Namsoo Kim, Danwei Wu, Damaris N. Lorenzo, Alexandra Badea, Yong-Hui Jiang, Henry H. Yin, William C. Wetsel, and Vann Bennett. “ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity..” Proc Natl Acad Sci U S A 116, no. 30 (July 23, 2019): 15262–71. https://doi.org/10.1073/pnas.1904348116.

PMID
31285321
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Pogorelov, Vladimir M., Hung-Teh Kao, George J. Augustine, and William C. Wetsel. “Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants..” Int J Neuropsychopharmacol 22, no. 7 (July 1, 2019): 453–65. https://doi.org/10.1093/ijnp/pyz019.

PMID
31188434
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Badea, Alexandra, Natalie A. Delpratt, R. J. Anderson, Russell Dibb, Yi Qi, Hongjiang Wei, Chunlei Liu, William C. Wetsel, Brian B. Avants, and Carol Colton. “Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease..” Magn Reson Imaging 60 (July 2019): 52–67. https://doi.org/10.1016/j.mri.2019.03.022.

PMID
30940494
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Shen, Yudao, John D. McCorvy, Michael L. Martini, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Karen M. Ward, William C. Wetsel, Jing Liu, Bryan L. Roth, and Jian Jin. “D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine..” J Med Chem 62, no. 9 (May 9, 2019): 4755–71. https://doi.org/10.1021/acs.jmedchem.9b00508.

PMID
30964661
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Arbogast, Thomas, Parisa Razaz, Jacob Ellegood, Spencer U. McKinstry, Serkan Erdin, Benjamin Currall, Tanya Aneichyk, et al. “Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions..” Hum Mol Genet 28, no. 9 (May 1, 2019): 1474–86. https://doi.org/10.1093/hmg/ddy436.

PMID
30590535
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguiz, Michael D. Kritzer, Angel V. Peterchev, Jeffrey Roach, William C. Wetsel, and Douglas E. Williamson. “Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice..” Sci Rep 9, no. 1 (March 1, 2019). https://doi.org/10.1038/s41598-019-40140-5.

PMID
30824791
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Huffman, William J., Saraswathi Subramaniyan, Ramona M. Rodriguiz, William C. Wetsel, Warren M. Grill, and Niccolò Terrando. “Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice..” Brain Stimul 12, no. 1 (January 2019): 19–29. https://doi.org/10.1016/j.brs.2018.10.005.

PMID
30337243
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguez, Michael D. Kritzer, Angel V. Peterchev, et al. “Correction: Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing..” Plos One 14, no. 2 (2019). https://doi.org/10.1371/journal.pone.0212712.

PMID
30779792
Full Text

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