William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Distinguished Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Dorling, James L., Eric Ravussin, Leanne M. Redman, Manju Bhapkar, Kim M. Huffman, Susan B. Racette, Sai K. Das, et al. “Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.” Eur J Nutr 60, no. 3 (April 2021): 1633–43. https://doi.org/10.1007/s00394-020-02361-7.

PMID
32803412
Full Text

Huffman, Kim M., Brian J. Andonian, Dennis M. Abraham, Akshay Bareja, David E. Lee, Lauren H. Katz, Janet L. Huebner, William E. Kraus, and James P. White. “Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.” J Appl Physiol (1985) 130, no. 3 (March 1, 2021): 853–64. https://doi.org/10.1152/japplphysiol.00576.2020.

PMID
33411638
Full Text

Hartiala, Jaana A., Yi Han, Qiong Jia, James R. Hilser, Pin Huang, Janet Gukasyan, William S. Schwartzman, et al. “Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.” Eur Heart J 42, no. 9 (March 1, 2021): 919–33. https://doi.org/10.1093/eurheartj/ehaa1040.

PMID
33532862
Full Text

Brooksbank, Jeremy A., Stephen J. Greene, Hailey M. Harris, Amanda Stebbins, Mona Fiuzat, David J. Whellan, Brooke Alhanti, et al. “Beta-blocker and ACE-inhibitor dosing as a function of body surface area: From the HF-ACTION trial.” Am Heart J 233 (March 2021): 1–4. https://doi.org/10.1016/j.ahj.2020.11.003.

PMID
33245905
Full Text

Speakman, John R., Yosuke Yamada, Hiroyuki Sagayama, Elena S. F. Berman, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, et al. “A standard calculation methodology for human doubly labeled water studies.” Cell Rep Med 2, no. 2 (February 16, 2021): 100203. https://doi.org/10.1016/j.xcrm.2021.100203.

PMID
33665639
Full Text

Feng, Kent Y., Christopher M. O’Connor, Robert Clare, Brooke Alhanti, Ileana L. Piña, William E. Kraus, David J. Whellan, and Robert J. Mentz. “Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure.” J Cardiovasc Transl Res, February 9, 2021. https://doi.org/10.1007/s12265-021-10104-0.

PMID
33564986
Full Text

Dorling, James L., Stephan van Vliet, Kim M. Huffman, William E. Kraus, Manjushri Bhapkar, Carl F. Pieper, Tiffany Stewart, et al. “Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.” Nutr Rev 79, no. 1 (January 1, 2021): 98–113. https://doi.org/10.1093/nutrit/nuaa085.

PMID
32940695
Full Text

Erickson, Melissa L., Karyn A. Esser, William E. Kraus, Thomas W. Buford, and Leanne M. Redman. “A Role for Exercise to Counter Skeletal Muscle Clock Disruption.” Exerc Sport Sci Rev 49, no. 1 (January 2021): 35–41. https://doi.org/10.1249/JES.0000000000000235.

PMID
33044328
Full Text

Bihlmeyer, Nathan A., Lydia Coulter Kwee, Clary B. Clish, Amy Anderson Deik, Robert E. Gerszten, Neha J. Pagidipati, Blandine Laferrère, et al. “Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.” Plos One 16, no. 5 (January 2021): e0240764. https://doi.org/10.1371/journal.pone.0240764.

PMID
34043632
Full Text

Ross, Leanna M., Cris A. Slentz, Alyssa M. Zidek, Kim M. Huffman, Irina Shalaurova, James D. Otvos, Margery A. Connelly, et al. “Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.” Front Physiol 12 (2021): 626142. https://doi.org/10.3389/fphys.2021.626142.

PMID
33613319
Full Text

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