Translational Research Approaches to Sugar-Induced Metabolic Disease

February 7, 2019 - 12:00pm to 1:00pm
CAGPM Weekly Forum Series
Mark Herman

Dr. Herman is a practicing endocrinologist and basic scientist studying molecular mechanisms by which overnutrition contributes to cardiometabolic disease. He received his MD from the University of Texas Southwestern and conducted his internal medicine training there as well. He moved to Boston for training in endocrinology at the Beth-Israel Deaconess Hospital and Joslin Diabetes Center at Harvard. His post-doctoral training in Dr. Barbara Kahn's laboratory at BIDMC focused on adipose tissue biology and led to multiple discoveries including a mechanism by which adipocytes sense and respond to changes in glucose flux and how this affects systemic glucose homeostasis in both animal models and humans. Dr. Herman established an independent laboratory at BIDMC in 2013 where he elucidated transcriptional mechanisms mediating the metabolic response to fructose consumption in animal models. With collaborators, Dr. Herman has translated molecular and mechanistic findings identified in mice to pursue translational studies to examine mechanisms of metabolic disease in human subjects and populations. Dr. Herman moved to Duke University two years ago and has continued to his work to provide fundamental insight into physiology that may provide innovative strategies for advancements in patient care related to cardiometaboli