Diamantidis to study racial differences in AKI

Friday, October 26, 2018

GIM Assistant Professor of Medicine, Clarissa Diamantidis, MD, and GIM Post Doc Fellow, Joseph Lunyera, MBChB, are the Principal Investigators on a new study looking at racial differences in Acute Kidney Injury (AKI). They were notified earlier this week that they were also recipients of a Duke REACH Equity research voucher, an award that will help offset the cost of analysis for this research study. 

"This is a wonderful example of the many possibilities for collaboration here at Duke."

“This is a wonderful example of the many possibilities for collaboration here at Duke," says Diamantidis. "Not only will this work bring together investigators in DGIM, Nephrology, Cardiology and the DCRI, it also provides access to the amazing researchers and health disparities expertise provided by the REACH Equity Center."

Here is the project summary: 

Manuscript title:
Racial & ethnic disparities in AKI outcomes following percutaneous coronary interventions

Principal Investigators: 
Joseph Lunyera, MBChB and Clarissa J. Diamantidis, MD

Co-Investigators:
Kevin Thomas, MD (Cardiology, DCRI)
Patrick Pun, MD (Nephrology, DCRI)
Julia Scialla, MD (Nephrology, DCRI)
Monique (Anderson) Starks, MD (Cardiology, DCRI)

Overview:
Racial disparities in incidence of acute kidney injury (AKI) are becoming increasingly apparent. Prior studies reported increased risk of AKI in blacks compared with whites in clinical contexts where AKI is prevalent such as among individuals with diabetes, stroke, and liver disease. Similarly, AKI is common among individuals undergoing percutaneous coronary interventions (PCI) and is associated with increased risk of adverse outcomes post-PCI, including recurrent AKI, persistent loss of kidney function, and mortality. While evidence suggests that blacks are at increased risk of AKI development in general, data describing racial disparities in incidence of AKI following PCI is scant. As such, using data from the Duke Databank for Cardiovascular Disease, we propose to compare the incidence rates of AKI and subsequent adverse outcomes post-AKI between blacks, Native Americans, or other races vs. whites who underwent PCI. We will use logistic regression models adjusted for age, sex, and comorbidity to examine our hypotheses.