New funding awards - July 2018

Friday, August 17, 2018

Sponsored Research

Christopher Granger of Cardiology has received an award for a project entitled "DCRI Race." Total funding will be $91,000.

Kuo Du (Mentor: Anna Mae Diehl) of Gastroenterology has received an award from the American Association for the Study of Liver Diseases for a project entitled "Pathophysiological Role of Glutaminolysis in Human NAFLD Progression." Total funding will be $100,000.

Cynthia A. Moylan of Gastroenterology has received an award from the American Association for the Study of Liver Diseases for a project entitled "Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease." Total funding will be $100,000.

Andrew J. Muir of Gastroenterology has received an award (3T32-DK007568-28S2) from the National Institutes of Health for a project entitled "Medical Student Research Training Supplement." Total funding will be $30,806.

Andrew J. Muir of Gastroenterology has received an award (5T32-DK007568-28S1) from the National Institutes of Health for a project entitled "T32-Diversity: NRSA Diversity Supplement Award." Total funding will be $66,725.

Julius Wilder of Gastroenterology has received an award from the American Association for the Study of Liver Diseases for a project entitled "The Impact of Race, Ethnicity, and Socioeconomic Status on Listing for Liver Transplant after Referral." Total funding will be $200,000.

Nrupen Bhavsar of General Internal Medicine has received an award (1K01-HL140146-01A1) from the National Institutes of Health for a project entitled "Addressing Bias from Missing Data in EHR Based Studies of CVD." Total funding will be $829,386.

Alexandra Johnson (Mentor: Gowthami Arepally) of Hematology has received an award (3R01-HL136512-01A1S1) from the National Institutes of Health for a project entitled "Complement and CR2/CD21 in the Immune Pathogenesis of HIT." Total funding will be $91,740.

Marilyn J. Telen of Hematology has received a sub-award through the University of Pittsburgh for a project entitled "Phase IIb randomized, double blind study to assess safety, tolerability, and efficacy of Riociguat in Sickle Cell Diseases." Total funding will be $52,566.

Gregory Gray of Infectious Diseases has received an award from the Womack Army Medical Center for a project entitled "Bioaerosol Sampling in a Military Medical Environment: A Pilot Study."

Mehri McKellar of Infectious Diseases has received an award from the Durham County Health Department for a project entitled "Integrated Targeted Testing Services (ITTS)."

John Perfect of Infectious Diseases has received an award (2R01-AI093257-06A1) from the National Institutes of Health for a project entitled "Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS." Total funding will be $1,803,873.

Daniel J. George of Medical Oncology has received an award (W81XWH-17-2-0021-PC161026 ) from the Department of Defense for a project entitled "PCRP Clinical Consortium: Duke University Clinical Research Site." Total funding will be $1,272,000.

Steven D. Crowley of Nephrology has received an award from the American Heart Association for a project entitled "The interleukin-1 receptor modulates blood pressure and renal tubular injury." Total funding will be $100,000.

Rasheeda K. Hall of Nephrology has received an award (1K76-AG059930-01) from the National Institutes of Health for a project entitled "Deprescribing for Older Dialysis Patients." Total funding will be $1,153,365.

Patrick H. Pun of Nephrology has received a sub-award (1R34-HL140477-01) through the Brigham and Women's Hospital for a project entitled "Randomized trials using point of care guided manipulation of dialysate potassium, dialysate bicarbonate, and ultrafiltration rate to prevent hemodialysis-associated arrhythmia." Total funding will be $98,881.

Claude A. Piantadosi of Pulmonary, Allergy, and Critical Care Medicine has received an award (N00014-18-1-2702) from the Office of Naval Research for a project entitled "Oxidative tissue damage mitigation after exposure to HBO2 using FDA approved anti-epileptic drugs (AEDs)." Total funding will be $988,057.

Industry-sponsored Clinical Trials

Terry A. Fortin of Cardiology has received an award from Lung Biotechnology for a project entitled "BEAT- An Open label extension of BPS-314d-MR-PAH-303." Total funding will be $50,109.

William S. Jones of Cardiology has received an award from Bayer HealthCare AG for a project entitled "VITALITY." Total funding will be $662,383.

Igor Klem of Cardiology has received an award from Medtronic, Inc. for a project entitled "Progression of Myocardial Fibrosis and the Impact on SCD Risk in DCM ї A Longitudinal CMR Study." Total funding will be $30,721.

Mitchell W. Krucoff of Cardiology has received an award from Biosensors Research USA, Inc. for a project entitled "MEDpiNET: Industry Funding." Total funding will be $35,000.

Erik M. Ohman of Cardiology has received an award from Abiomed for a project entitled "CRISP-AMI Data Analysis." Total funding will be $64,497.

Eric D. Peterson of Cardiology has received an award from Amgen, Inc. for a project entitled "DCRI Think Tank." Total funding will be $50,000.

Jonathan P. Piccini of Cardiology has received an award from Spectranetics for a project entitled "Spectranetics/Duke Educational Program." Total funding will be $30,670.

Matthew T. Roe of Cardiology has received an award from Sanofi US for a project entitled "ODYSSEY Outcomes:  Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment with Alirocumab." Total funding will be $207,249.

David D'Alessio of Endocrinology, Metabolism, and Nutrition has received an award from vTv Therapeutics LLC for a project entitled "A multi-center, randomized, double-blind, parallel-group, multiple dose, adaptive study assessing the pharmacokinetics, pharmacodynamics, safety and tolerability of TTP399 in adult patients with type 1 diabetes mellitus." Total funding will be $69,842.

Andrew J. Muir of Gastroenterology has received an award from DOVA Pharmaceuticals for a project entitled "An Observational Cohort Study of the Use of Avatrombopag in Patients with Thrombocytopenia Associated with Chronic Liver Disease Undergoing a Procedure." Total funding will be $39,711.

Cristina Gasparetto of Hematologic Malignancies and Cellular Therapy has received an award from AbbVie Inc. for a project entitled "A Phase 1/2, Multicenter, Dose-Escalation and Expansion Study of Combination Therapy with Venetoclax, Daratumumab and Dexamethasone (with and without Bortezomib) in Subjects with Relapsed or Refractory Multiple Myeloma." Total funding will be $575,829.

Matthew S. McKinney of Hematologic Malignancies and Cellular Therapy has received an award from BeiGene, Ltd for a project entitled "BeiGene BGB-3111-212 An International, Phase 2, Open-Label, Randomized Study of BGB-3111 Combined with Obinutuzumab Compared With Obinutuzumab Monotherapy in Relapsed/Refractory Follicular Lymphoma." Total funding will be $287,089.

Matthew S. McKinney of Hematologic Malignancies and Cellular Therapy has received an award from Denovo Biopharma, LLC for a project entitled "Denovo DB102-02 A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Enzastaurin Plus R-CHOP Versus R-CHOP in Treatment-Naive Subjects with High-Risk Diffuse Large B-Cell Lymphoma Who Possess the Novel Genomic Biomarker DGM1ї." Total funding will be $165,358.

David Rizzieri of Hematologic Malignancies and Cellular Therapy has received an award from Pfizer, Inc. for a project entitled "An Open Label Phase IB study of PF-04449913 (Glasdegib) in Combination with Azacitidine in patients with previously untreated higher-risk myelodysplastic syndrome, acute myeloid leukemia." Total funding will be $269,550.

Murat O. Arcasoy of Hematology has received an award from Samus Therapeutics, Inc. for a project entitled "A phase 1b Study of Ruxolitinib in Combination with PU-H71 for the treatment of Subjects with Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (post-PV MF)." Total funding will be $299,986.

Ara D. Metjian of Hematology has received an award from Baim Institute for Clinical Research for a project entitled "Prospective Randomized open blinded end-point (PROBE) study." Total funding will be $56,001.

Andrew Armstrong of Medical Oncology has received an award from the Bristol-Myers Squibb Company for a project entitled "A Phase 2 Study of Nivolumab in combination with either Rucaparib, docetaxel, or enzalutamide in men with Castration-resistant metastaic prostate cancer (CheckMate 9KD: CHECKpoint pathway and nivoluMA." Total funding will be $227,346.

Jennifer Choe of Medical Oncology has received an award from Blueprint Medicines Corporation for a project entitled "An International, Multicenter, Open-label, Randomized, Phase 3 Study of BLU-285 vs Regorafenib in Patients with Locally Advanced Unresectable or Metastatic Gastrointestinal Stromal Tumor (GIST)." Total funding will be $146,677.

Michael R. Harrison of Medical Oncology has received an award from the Bristol-Myers Squibb Company for a project entitled "Ipilimumab and Nivolumab Combination Therapy: A Randomized Study of an Immediate versus Delayed Exercise Intervention with FuNctional Capacity and Quality of Life Evaluations in Subjects with Advanced." Total funding will be $491,633.

Michael A. Morse of Medical Oncology has received an award from AstraZeneca AB for a project entitled "A Randomized, Open-label, Multi-center Phase III Study of Durvalumab and Tremelimumab as First-line Treatment in Patients with Unresectable Hepatocellular Carcinoma (HIMALAYA)." Total funding will be $249,635.

Andrew B. Nixon of Medical Oncology has received an award through the Alliance Foundation Trials, LLC for a project entitled "ATOMIC - Immune Cell Isolation." Total funding will be $560,290.

Alice L. Gray of Pulmonary, Allergy, and Critical Care Medicine has received an award from Vertex Pharmaceuticals Inc. for a project entitled "VX17-659-105 Open Label A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation ." Total funding will be $94,587.

Alice L. Gray of Pulmonary, Allergy, and Critical Care Medicine has received an award from Proteostasis Therapeutics for a project entitled "PTI 428-06: A phase 2 multicenter randomized double blind placebo controlled study to assess the safety tolerability pharmacokinetics and effect of PTI-428 in subjects with cystic fibrosis." Total funding will be $114,969.