New funding awards - June 2019

Tuesday, July 30, 2019

Sponsored Research

Robert Lefkowitz of Cardiology has received an award (2R01-HL016037-47) from the National Institutes of Health for a project entitled "Molecular Regulation of Cardiovascular 7 TM Receptors." Total funding will be $3,159,765.

Robert Mentz of Cardiology has received a sub-award (7U01-HL125511-02) through the Yale University for a project entitled "TRANSFORM-HF CCC (Subcontract with Yale)." Total funding will be $1,111,065.

Kristin Newby of Cardiology has received an award from the American Heart Association for a project entitled "AHA Scientific Sessions Abstract Submission." Total funding will be $15,000.

James Tcheng of Cardiology has received an award from the The Foundation of FirstHealth for a project entitled "PCI QA Review." Total funding will be $25,000.

Matthew Hirschey of Endocrinology has received an award (1R21-CA228342-01A1) from the National Institutes of Health for a project entitled "Determining the Sub-Cellular Organelles that Link Lipid Signaling and Epigenetics." Total funding will be $385,084.

Matthew Hirschey of Endocrinology has received an award (3R01-DK115568-02S1) from the National Institutes of Health for a project entitled "Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism." Total funding will be $140,569.

Deborah Muoio of Endocrinology has received an award (2R01-DK089312-09) from the National Institutes of Health for a project entitled "Mechanisms of lipid-induced bioenergetic stress in muscle." Total funding will be $2,372,746.

Sarah M. Gray (Mentor: Jenny Tong) of Endocrinology has received an award (1F31-DK121420-01A1) from the National Institutes of Health for a project entitled "Nutrient-dependent action of glucagon and GLP-1 in glucose metabolism and insulin secretion." Total funding will be $86,897.

Laura Rupprecht (Mentor: Diego Bohorquez) of Gastroenterology has received an award from the Hartwell Foundation for a project entitled "Targeting Fat Sensing in the Gut to Treat Autism Spectrum Disorder." Total funding will be $50,000.

Farr Curlin of General Internal Medicine has received an award from the Greenwall Foundation for a project entitled "Stemming the Opioid Epidemic." Total funding will be $216,629.

Harry Erba of Hematologic Malignancies and Cellular Therapy has received a sub-award (2U10-CA180888-06) through the Oregon Health & Science University for a project entitled "NCTN Network Group Operations Center." Total funding will be $75,310.

Marilyn Telen of Hematology has received an award from the Doris Duke Charitable Foundation for a project entitled "High-throughput Metabolite Profiling and Genetic Analyses to Identify Novel Predictive Biomarkers of SCD-related Complications." Total funding will be $486,000.

Brent Hanks of Medical Oncology has received a sub-award () through the Goldman Sachs Philanthropy Fund for a project entitled "Oncolytic Viral Delivery of Exosomal miRNAs as a Strategy for Metabolically Reprogramming the Tumor Immune Microenvironment and Enhancing the Efficacy of Immunotherapy." Total funding will be $100,000.

Xunrong Luo of Nephrology has received an award from the Juvenile Diabetes Research Foundation for a project entitled "LNFPIII and GAS6 Signaling Nanoparticles for Tolerance Delivery." Total funding will be $119,001.

Patty Lee of Pulmonary has received an award from the Burroughs Wellcome Fund for a project entitled "MIF-based Therapies for Severe Lung Disease." Total funding will be $12,500.

Kamran Mahmood of Pulmonary has received an award from the Lung Cancer Initiative of North Carolina for a project entitled "Lymphocyte exhaustion markers in malignanc pleural effusions of lung cancer." Total funding will be $25,000.

David Murdoch of Pulmonary has received an award (1R01-DA048627-01) from the National Institutes of Health for a project entitled "Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users." Total funding will be $3,866,081.

Laurie Snyder of Pulmonary has received an award from the Cystic Fibrosis Foundation Therapeutics, Inc. for a project entitled "Duke - UNC Cystic Fibrosis Tissue Procurement Partnership." Total funding will be $12,448.

Laurie Snyder of Pulmonary has received a sub-award (GODFRE19QI0) through the Dartmouth College for a project entitled "Cystic Fibrosis Lung Transplant Transition - Regional Dissemination Network." Total funding will be $9,720.

Lorenzo Zaffiri of Pulmonary has received a sub-award () through the Steward St. Elizabeth's Medical Center of Boston Inc. for a project entitled "Impact of Pre-transplant Anti-fibrotic Therapy for IPF Upon Lung Transplant Outcomes." Total funding will be $15,500.

Megan Clowse of Rheumatology has received a sub-award (R01-AI132421-01A1) through the University of North Carolina - Chapel Hill for a project entitled "Lysosome Defects and the Accumulation of Immune Complexes in Human Lupus." Total funding will be $51,958.

Victoria A. Wickenheisser (Mentor: Teresa Tarrant) of Rheumatology has received an award from the Rheumatology Research Foundation for a project entitled "Medical and Graduate Student Preceptorship." Total funding will be $1,000.

Industry-sponsored Clinical Trials

Gary Felker of Cardiology has received an award from The Bristol-Myers/Sanofi Pharmaceuticals, Inc. Partnership for a project entitled "Analysis Of ASCEND Data: Test Hierarchical (Pocock Style Win Ratio) Endpoints." Total funding will be $30,000.

Michel Khouri of Cardiology has received an award from Eidos Therapeutics for a project entitled "AG10-301 ATTRIBUTE." Total funding will be $998,966.

Michel Khouri of Cardiology has received an award from Moleculin Biotech, Inc. for a project entitled "Phase 1/2 Study of Liposomal Annamycin for the Treatment of Subjects with Acute Myeloid Leukemia (AML) that is Refractory to or Relapsed after Standard Induction Therapy." Total funding will be $144,921.

Renato Lopes of Cardiology has received an award from Bristol-Myers Squibb Company for a project entitled "AUGUSTUS Trial Secondary Manuscripts." Total funding will be $881,038.

Renato Lopes of Cardiology has received an award from Sanofi US for a project entitled "TDAP Study." Total funding will be $138,766.

Robert Mentz of Cardiology has received an award from Novartis Consumer Health, Inc. for a project entitled "PARAGLIDE." Total funding will be $924,683.

Sudarshan Rajagopal of Cardiology has received an award from Altavant Sciences, Inc. for a project entitled "RVT-1201 A Phase 2a, Double-Blind Placebo-Controlled Multicenter Study to Assess the Safety tolerability pharmacokinetics and pharmacodynamic effects of RVT-1201 in Patients with PAH." Total funding will be $88,435.

Manal Abdelmalek of Gastroenterology has received an award from Madrigal Pharmaceuticals, Inc. for a project entitled "A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation." Total funding will be $362,851.

Manal Abdelmalek of Gastroenterology has received an award from Novo Nordisk A/S for a project entitled "Investigation of efficacy and safety of semaglutide s.c. once-weekly versus placebo in subjects with non-alcoholic steatohepatitis and compensated liver cirrhosis." Total funding will be $62,244.

Amy Barto of Gastroenterology has received an award from Rebiotix Inc. for a project entitled "A Phase 3 Prospective, Randomized, Double-blinded, Placebo-controlled Clinical Study to Evaluate the Efficacy and safety of Rebiotix RBX2660 (microbiota suspension) for the Prevention of Recurrent Clostridium difficile Infection." Total funding will be $58,670.

Matthew McKinney of Hematologic Malignancies and Cellular Therapy has received an award from Genentech, Inc. for a project entitled "A PHASE I/II TRIAL OF MOSUNETUZUMAB (BTCT4465A) AS CONSOLIDATION THERAPY IN PATIENTS WITH DIFFUSE LARGE B-CELL LYMPHOMA FOLLOWING FIRST-LINE IMMUNOCHEMOTHERAPY AND AS THERAPY IN PATIENTS WITH PREVIOUS." Total funding will be $605,099.

Gregory Gray of Infectious Diseases has received a sub-award (N6264518D5058) through Vysnova Partners, Inc. for a project entitled "Asia Surveillance for Acute Novel Respiratory Infections (ASANRI) in Vietnam Year 3." Total funding will be $45,000.

Jennifer Choe of Medical Oncology has received an award from Xencor, Inc for a project entitled "A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®23104 in Subjects with Selected Advanced Solid Tumors (DUET-3)." Total funding will be $482,774.

Jennifer Choe of Medical Oncology has received an award from Exelixis, Inc for a project entitled "A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects with Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed after Prior VEGFR-Targeted Therapy." Total funding will be $362,637.