New funding awards - May 2015

Wednesday, June 10, 2015

Department of Medicine faculty have received notice of the following research, clinical trials, CME or other training awards.

Sponsored research

Chetan B. Patel of Cardiology has received a sub-award (CDR-1310-06998) through the University of Colorado - Denver for a project entitled "A multicenter trial of a novel decision aid for patients and their caregivers offered destination therapy left ventricular assist device." Total funding will be $73,238.

Sudarshan Rajagopal of Cardiology has received an award through the University of California - San Diego for a project entitled "US CTEPH Registry." Total funding will be $87,550.

Sudha Shenoy of Cardiology has received an award from the American Heart Association for a project entitled "De-ubiquitination of beta adrenergic receptors and left ventricular hypertrophy." Total funding will be $77,000.

Ashley Williams (Mentor: Deborah Muoio) of Endocrinology, Metabolism, and Nutrition has received an award (1F32-DK105922-01) from the National Institutes of Health for a project entitled "Mitochondrial Protein Acetylation and Energy Metabolism in Muscle." Total funding will be $157,290.

Ebony Boulware of General Internal Medicine has received a sub-award (HHSN268201300047C) through the University of Mississippi Medical Center for a project entitled "Jackson Heart Study Kidney Disease Working Group." Total funding will be $22,248.

Cristina Gasparetto of Hematological Malignancies and Cellular Therapy has received an award from the National Marrow Donor Program for a project entitled "Multicenter Phase II, Double-blind Placebo Controlled Trial of Maintenance Ixazomib BMT CTN 1302."

Vivian H. Chu of Infectious Diseases has received an award (HHSN272200900023C) from the National Institutes of Health for a project entitled "A Phase lll Multi-Center, Randomized, Open-label, Comparative Study to Assess the Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Patients with Intravenous Catheter-Associated Bloodstream Infections (BSI) due to Staphylococci."

Mehri McKellar of Infectious Diseases has received a sub-award (R24-AG044325-) through Wake Forest University Health Sciences for a project entitled "Developing a Testable Psychoeducation Program for Informal Caregivers of Persons Living with HIV/AIDS and Associated Neurocognitive Disorders." Total funding will be $5,000.

Susanna Naggie of Infectious Diseases has received a sub-award (1U01-HL123336-) through Massachusetts General Hospital for a project entitled "Randomized Trial to Prevent Vascular Events in HIV- REPRIEVE (A5332)."

Melissa E. Hector-Greene (Mentor: Gerard C. Blobe) of Medical Oncology has received an award (1F31-CA196239-01) from the National Institutes of Health for a project entitled "The Role of Type III TGF-beta Receptor in ALK1-mediated Tumor Angiogenesis." Total funding will be $67,654.

Shiaowen D. Hsu of Medical Oncology has received an award (1R21-CA185807-01A1) from the National Institutes of Health for a project entitled "Targeting Calreticulin in Colorectal Cancer Liver Metastasis." Total funding will be $380,045.

Thomas M. Coffman of Nephrology has received an award (1R01-DK105049-01) from the National Institutes of Health for a project entitled "Paracrine Control of Blood Pressure by Renal Intercalated Cells." Total funding will be $1,788,000.

Stacy A. Johnson (Mentor: Susan B. Gurley) of Nephrology has received an award from the ASN Foundation for Kidney Research for a project entitled "The Role of Branched-chain Amino Acids in Diabetic Nephropathy." Total funding will be $100,000.

Lesley H. Curtis of Other Medicine has received a sub-award (HHSN268201300036C) through the University of Washington for a project entitled "CHS." Total funding will be $19,911.

Claude A. Piantadosi of Pulmonary, Allergy, and Critical Care Medicine has received an award (N00014-15-1-2072) from the Office of Naval Research for a project entitled "Critical Molecular Targets for the Toxic Effects of Hyperbaric Oxygen and a Novel Pharmacological Approach for Preventing Acute Toxicity." Total funding will be $1,094,199.

Megan E. Clowse of Rheumatology and Immunology has received a sub-award (2U54-AR057319-12) through the University of Pennsylvania for a project entitled "University of Pennsylvania to Duke Subaward for U54 Grant." Total funding will be $8,898.

Industry-sponsored clinical trials

Camille G. Frazier-Mills of Cardiology has received an award from Medtronic, Inc. for a project entitled "Wrap-it." Total funding will be $40,424.

Thomas J. Povsic of Cardiology has received an award from Cardio3 Biosciences for a project entitled "CHART2." Total funding will be $425,992.

Eric Velazquez of Cardiology has received an award from Alnylam Pharmaceuticals for a project entitled "A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis." Total funding will be $48,552.

Tracy Y. Wang of Cardiology has received an award from Boston Scientific Corporation for a project entitled "Evaluation of Reasons for ICDs not being Implanted after MI." Total funding will be $58,557.

Andrew J. Muir of Gastroenterology has received an award from Merck Sharp & Dohme for a project entitled "Merck MK-5172-017-02 A long-term follow-up study to evaluate the durability of Viro-Logic response and/or viral resistance patterns of subjects with Chronic Hepatitis C who have been previously treated with MK-5172 in a prior clinical trial." Total funding will be $78,182.

Rowena J. Dolor of General Internal Medicine has received an award from Janssen Research & Development, LLC for a project entitled "CaRE Trial." Total funding will be $213,844.

Connie Bales of Geriatrics has received an award from Dairy Management, Inc. for a project entitled "An Enhanced Protein (Dairy) Weight Loss Intervention for Dynapenic Obesity: Impact on Muscle Quality and Composition." Total funding will be $497,772.

Gwynn D. Long of Hematological Malignancies and Cellular Therapy has received an award from Novartis Pharmaceuticals Corporation for a project entitled "A multi-center study to evaulate the efficacy and safety of CSJ148." Total funding will be $136,197.

David Rizzieri of Hematological Malignancies and Cellular Therapy has received an award from Karyopharm Therapeutics for a project entitled "Phase II study of SINE (KPT-330) vs SOC in patients with R/R AML." Total funding will be $94,887.

Jeffrey Crawford of Medical Oncology has received an award from Celgene Corporation for a project entitled "CELGENE SOLID TUMOR PRACTICUM." Total funding will be $77,280.

Stephanie Gaillard of Medical Oncology has received an award from the Bristol-Myers Squibb Company for a project entitled "A phase I/IIa study of BMS986148 a Mesothelin directed antibody drug conjugate in subjects with select advanced solid tumors." Total funding will be $587,171.

Michael R. Harrison of Medical Oncology has received an award from Acerta Pharma for a project entitled "Randomized Phase 2 Trial of ACP-196 and Pembrolizumab Immunotherapy Dual Checkpoint Inhibition in Platinum Resistant Metastatic Urothelial Carcinoma." Total funding will be $413,562.

Neal E. Ready of Medical Oncology has received an award from AstraZeneca Pharmaceuticals, LP for a project entitled "A phase II, multi-center, single-arm, global study of MEDI4736 monotherapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN)." Total funding will be $273,897.

April K. Salama of Medical Oncology has received an award from Bristol-Myers/Sanofi Pharmaceuticals, Inc. Partnership for a project entitled "BMS CA209-238-0025 A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy with Nivolumab versus Ipilimumab after Complete Resection of Stage IIIb/c or Stage IV Melanoma in Subjects who are at high risk for recurrence." Total funding will be $282,011.

John P. Middleton of Nephrology has received an award from Janssen Research & Development, LLC for a project entitled "Protocol No. 28431754DNE3001: "A Randomized, Double-blind, Event-driven, Placebo-controlled, Multicenter Study of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects With Type 2 Diabetes Mellitus and Diabetic Nephropathy." Total funding will be $503,419.

Neil R. MacIntyre of Pulmonary, Allergy, and Critical Care Medicine has received an award from GlaxoSmithKline for a project entitled "GSK Study CTT116855." Total funding will be $345,748.

Momen Wahidi of Pulmonary, Allergy, and Critical Care Medicine has received an award from Mercator MedSystems, Inc. for a project entitled "BROADWAY: Broncho-Adventitial Delivery of Paclitaxel to Extend Airway Patency in Malignant Airway Obstruction Patients." Total funding will be $5,100.