Svati Shah: genetic and molecular epidemiology of cardiovascular disease

Monday, March 14, 2011

Svati Shah,MD, assistant professor of medicine (Cardiology), will present “Genomics and Metabolomics of Cardiovascular Disease” at Medicine Research Conference Fri., March 25, 2011 at 12noon (lunch is provided, and all Medicine research faculty are strongly urged to attend).

We caught up with her in the echo lab and asked her to introduce her research.

Shah's 2010 paper, Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events, was selected for the AHA's Top Advances in Functional Genomics and Translational Biology for 2010

In this study investigators evaluated 69 discrete peripheral blood metabolites measured by liquid chromatography-MS/MS, and related groups of metabolites via principal components analysis (PCA), for association with CAD and subsequent event risk in individuals undergoing cardiac catheterization for suspected risk.

Employing discovery and replication samples, Shah and colleagues found and replicated in independent samples the association of several individual metabolites (leucine/isoleucine, glutamate/glutamine, long-chain acylcarnitines) with prevalent CAD, and groups of factors (branch-chain amino acid related, urea-cycle related) with CAD and with subsequent cardiovascular events (short-chain dicarboxylacylcarnitines) after median follow-up of 2.7 years.

Analyses adjusted for risk factors and potential confounders generally remained significant, and the addition of metabolites to risk models improved c-statistics suggesting metabolites may eventually provide additional predictive information beyond traditional risk factors for prevalent CAD and subsequent events.

Shah, S., Bain, J., Muehlbauer, M., Stevens, R., Crosslin, D., Haynes, C., Dungan, J., Newby, L., Hauser, E., Ginsburg, G., Newgard, C., & Kraus, W. (2010). Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events Circulation: Cardiovascular Genetics, 3 (2), 207-214 DOI: 10.1161/CIRCGENETICS.109.852814