Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Payne, EH, Ramalingam, D, Fox, DT, and Klotman, ME. "Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells." Journal of virology 92, no. 2 (January 2018).

PMID
29093088
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Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." Molecular therapy : the journal of the American Society of Gene Therapy 24, no. 11 (November 2016): 2021-2032.

PMID
27455880
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Chen, P, Yi, Z, Zhang, W, Klotman, ME, and Chen, BK. "HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response." AIDS (London, England) 30, no. 12 (July 2016): 1877-1888.

PMID
27163710
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Blasi, M, Carpenter, JH, Balakumaran, B, Cara, A, Gao, F, and Klotman, ME. "Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine." AIDS (London, England) 29, no. 13 (August 2015): 1651-1657.

PMID
26372275
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Michelini, Z, Negri, D, Biava, M, Baroncelli, S, Spada, M, Leone, P, Bona, R, Blasi, M, Nègre, D, Klotman, ME, and Cara, A. "Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice." Viral immunology 27, no. 10 (December 2014): 512-520.

PMID
25343523
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Carethers, JM, Coughlin, S, Diamond, B, Erzurum, S, Fried, LP, Jameson, JL, Kaushansky, K, Klotman, ME, Lemon, S, Mitchell, B, Rothman, P, Sawyers, C, Seidman, C, and Somlo, S. "The imperative to invest in science has never been greater." The Journal of clinical investigation 124, no. 11 (November 2014): 5085-.

PMID
25365077
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Blasi, M, Balakumaran, B, Chen, P, Negri, DRM, Cara, A, Chen, BK, and Klotman, ME. "Renal epithelial cells produce and spread HIV-1 via T-cell contact." AIDS (London, England) 28, no. 16 (October 2014): 2345-2353.

PMID
25062092
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Carethers, JM, Coughlin, S, Diamond, B, Erzurum, S, Fried, LP, Jameson, JL, Kaushansky, K, Klotman, ME, Lemon, S, Mitchell, B, Rothman, P, Sawyers, C, Seidman, C, and Somlo, S. "The imperative to invest in science has never been greater." Journal of Clinical Investigation 124, no. 9 (September 2, 2014): 3680-3681.

PMID
25180532
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Blasi, M, Balakumaran, B, Chen, P, Negri, DRM, Cara, A, Chen, BK, and Klotman, ME. "Renal epithelial cells produce and spread HIV-1 via T-cell contact." AIDS 28, no. 16 (January 1, 2014): 2345-2353.

Full Text

Rossi, A, Michelini, Z, Leone, P, Borghi, M, Blasi, M, Bona, R, Spada, M, Grasso, F, Gugliotta, A, Klotman, ME, Cara, A, and Negri, D. "Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector." PloS one 9, no. 9 (January 2014): e107377-.

PMID
25210766
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