John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Minter, S, Armour, A, Tinnemore, A, Strub, K, Crowley, AL, Bloomfield, GS, Alexander, JH, Douglas, PS, Kisslo, JA, Velazquez, EJ, and Samad, Z. "Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation." The International Journal of Cardiovascular Imaging 34, no. 11 (November 2018): 1725-1730.

PMID
30128849
Full Text

Sharma, A, Hijazi, Z, Andersson, U, Al-Khatib, SM, Lopes, RD, Alexander, JH, Held, C, Hylek, EM, Leonardi, S, Hanna, M, Ezekowitz, JA, Siegbahn, A, Granger, CB, and Wallentin, L. "Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation." Circulation 138, no. 16 (October 2018): 1666-1676.

PMID
29871978
Full Text

Lopes, RD, de Barros E Silva, PGM, de Andrade Jesuíno, I, Santucci, EV, Barbosa, LM, Damiani, LP, Nakagawa Santos, RH, Laranjeira, LN, Dall Orto, FTC, Beraldo de Andrade, P, de Castro Bienert, IR, Alexander, JH, Granger, CB, and Berwanger, O. "Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial." Jama Cardiology (September 24, 2018).

PMID
30264159
Full Text

Smith, PJ, Browndyke, JN, Monge, ZA, Harshbarger, TB, James, ML, Gaca, JG, Alexander, JH, Berger, MM, Newman, MF, Milano, CA, Mathew, JP, and Neurologic Outcomes Research Group (NORG), . "Longitudinal Changes in Regional Cerebral Perfusion and Cognition Following Cardiac Surgery." The Annals of Thoracic Surgery (September 22, 2018).

PMID
30253158
Full Text

Christersson, C, Wallentin, L, Andersson, U, Alexander, JH, Alings, M, De Caterina, R, Gersh, BJ, Granger, CB, Halvorsen, S, Hanna, M, Huber, K, Hylek, EM, Lopes, RD, Oh, B-H, and Siegbahn, A. "Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation." Heart (British Cardiac Society) (September 12, 2018).

PMID
30209126
Full Text

Samad, Z, Shaw, LK, Phelan, M, Glower, DD, Ersboll, M, Toptine, JH, Alexander, JH, Kisslo, JA, Wang, A, Mark, DB, and Velazquez, EJ. "Long-term outcomes of mitral regurgitation by type and severity." American Heart Journal 203 (September 2018): 39-48.

PMID
30015067
Full Text

Vinereanu, D, Wang, A, Mulder, H, Lopes, RD, Jansky, P, Lewis, BS, Gersh, BJ, Avezum, A, Hanna, M, Held, C, Wallentin, L, Granger, CB, and Alexander, JH. "Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease." Heart (British Cardiac Society) 104, no. 15 (August 2018): 1292-1299.

PMID
29352007
Full Text

Fanaroff, AC, Steffel, J, Alexander, JH, Lip, GYH, Califf, RM, and Lopes, RD. "Stroke prevention in atrial fibrillation: re-defining 'real-world data' within the broader data universe." European Heart Journal 39, no. 32 (August 2018): 2932-2941.

PMID
29688403
Full Text

Horowitz, JD, De Caterina, R, Heresztyn, T, Alexander, JH, Andersson, U, Lopes, RD, Steg, PG, Hylek, EM, Mohan, P, Hanna, M, Jansky, P, Granger, CB, Wallentin, L, and ARISTOTLE Investigators, . "Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation: An ARISTOTLE Substudy." Journal of the American College of Cardiology 72, no. 7 (August 2018): 721-733.

PMID
30092948
Full Text

Inohara, T, Pieper, K, Wojdyla, DM, Patel, MR, Jones, WS, Tricoci, P, Mahaffey, KW, James, SK, Alexander, JH, Lopes, RD, Wallentin, L, Ohman, EM, Roe, MT, and Vemulapalli, S. "Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome." American Heart Journal 201 (July 2018): 25-32.

PMID
29910052
Full Text

Pages