John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Browndyke, JN, Berger, M, Smith, PJ, Harshbarger, TB, Monge, ZA, Panchal, V, Bisanar, TL, Glower, DD, Alexander, JH, Cabeza, R, Welsh-Bohmer, K, Newman, MF, Mathew, JP, and Duke Neurologic Outcomes Research Group (NORG), . "Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults. (Accepted)" Human brain mapping 39, no. 2 (February 2018): 985-1003.

PMID
29164774
Full Text

Vinereanu, D, Wang, A, Mulder, H, Lopes, RD, Jansky, P, Lewis, BS, Gersh, BJ, Avezum, A, Hanna, M, Held, C, Wallentin, L, Granger, CB, and Alexander, JH. "Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease." Heart (British Cardiac Society) (January 19, 2018).

PMID
29352007
Full Text

Gulack, BC, Kirkwood, KA, Shi, W, Smith, PK, Alexander, JH, Burks, SG, Gelijns, AC, Thourani, VH, Bell, D, Greenberg, A, Goldfarb, SD, Mayer, ML, Bowdish, ME, and Cardiothoracic Surgical Trials Network (CTSN), . "Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study." The Journal of thoracic and cardiovascular surgery (December 5, 2017).

PMID
29221750
Full Text

Melloni, C, Dunning, A, Granger, CB, Thomas, L, Khouri, MG, Garcia, DA, Hylek, EM, Hanna, M, Wallentin, L, Gersh, BJ, Douglas, PS, Alexander, JH, and Lopes, RD. "Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial." December 2017.

PMID
28739198
Full Text

Gaudino, M, Alexander, JH, Bakaeen, FG, Ballman, K, Barili, F, Calafiore, AM, Davierwala, P, Goldman, S, Kappetein, P, Lorusso, R, Mylotte, D, Pagano, D, Ruel, M, Schwann, T, Suma, H, Taggart, DP, Tranbaugh, RF, and Fremes, S. "Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial-rationale and study protocol." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 52, no. 6 (December 2017): 1031-1040.

PMID
29059371
Full Text

Vinereanu, D, Lopes, RD, Mulder, H, Gersh, BJ, Hanna, M, de Barros E Silva, PGM, Atar, D, Wallentin, L, Granger, CB, Alexander, JH, and ARISTOTLE Investigators, . "Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin." Stroke 48, no. 12 (December 2017): 3266-3273.

PMID
29089455
Full Text

Mehta, RH, Alexander, JH, and LEVO-CTS Steering Committee Members and Trial Investigators, . "Levosimendan in Cardiac Surgery." The New England journal of medicine 377, no. 19 (November 9, 2017): 1900-1901. (Letter)

PMID
29120128
Full Text

Rao, MP, Vinereanu, D, Wojdyla, DM, Alexander, JH, Atar, D, Hylek, EM, Hanna, M, Wallentin, L, Lopes, RD, Gersh, BJ, Granger, CB, and Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators, . "Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial." The American journal of medicine (November 6, 2017).

PMID
29122636
Full Text

Hijazi, Z, Oldgren, J, Lindbäck, J, Alexander, JH, Connolly, SJ, Eikelboom, JW, Ezekowitz, MD, Held, C, Hylek, EM, Lopes, RD, Yusuf, S, Granger, CB, Siegbahn, A, and Wallentin, L. "A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score." European heart journal (October 21, 2017).

PMID
29069359
Full Text

Koshizaka, M, Lopes, RD, Newby, LK, Clare, RM, Schulte, PJ, Tricoci, P, Mahaffey, KW, Ogawa, H, Moliterno, DJ, Giugliano, RP, Huber, K, James, S, Harrington, RA, and Alexander, JH. "Obesity, Diabetes, and Acute Coronary Syndrome: Differences Between Asians and Whites." The American journal of medicine 130, no. 10 (October 2017): 1170-1176.

PMID
28396226
Full Text

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