Mary E. Klotman, MD, Primary Investigator
Mary E. Klotman, MD
Department of Medicine
Durham, NC 27710
Phone: (919) 668-1755
Email address: email@example.com
Bala Balakumaran, PhD
Senior Research Associate
Maria Blasi, PhD
Donatella Negri, PhD
Andrea Cara, PhD
The Klotman Lab is lead by Mary E. Klotman, MD, professor of medicine.
The lab focuses on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.
Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease.
Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.
Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine.
Integrase Defective Lentiviral Vector (IDLV)-ENV Immunogen Strategy for an HIV Vaccine