Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Cooper, LB, Hammill, BG, Allen, LA, Lindenfeld, J, Mentz, RJ, Rogers, JG, Milano, CA, Patel, CB, Alexander, KP, and Hernandez, AF. "Assessing Frailty in Patients Undergoing Destination Therapy Left Ventricular Assist Device: Observations from Interagency Registry for Mechanically Assisted Circulatory Support." ASAIO journal (American Society for Artificial Internal Organs : 1992) 64, no. 1 (January 2018): 16-23.

PMID
28525417
Full Text

Krishnaswami, A, Maurer, MS, and Alexander, KP. "Contextualizing Myocardial Infarction: Comorbidities and Priorities in Older Adults." The American journal of medicine 130, no. 10 (October 2017): 1144-1147. (Review)

PMID
28687265
Full Text

Alexander, KP. "Walking as a Window to Risk and Resiliency." Circulation 136, no. 7 (August 2017): 644-645.

PMID
28588078
Full Text

Bagai, A, Alexander, KP, Berger, JS, Senior, R, Sajeev, C, Pracon, R, Mavromatis, K, Lopez-Sendón, JL, Gosselin, G, Diaz, A, Perna, G, Drozdz, J, Humen, D, Petrauskiene, B, Cheema, AN, Phaneuf, D, Banerjee, S, Miller, TD, Kedev, S, Schuchlenz, H, Stone, GW, Goodman, SG, Mahaffey, KW, Jaffe, AS, Rosenberg, YD, Bangalore, S, Newby, LK, Maron, DJ, Hochman, JS, and Chaitman, BR. "Use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis." American heart journal 190 (August 2017): 135-139.

PMID
28760208
Full Text

Posenau, JT, Wojdyla, DM, Shaw, LK, Alexander, KP, Ohman, EM, Patel, MR, Smith, PK, and Rao, SV. "Revascularization Strategies and Outcomes in Elderly Patients With Multivessel Coronary Disease." The Annals of thoracic surgery 104, no. 1 (July 2017): 107-115.

PMID
28109574
Full Text

Neeland, IJ, Das, SR, Simon, DN, Diercks, DB, Alexander, KP, Wang, TY, and de Lemos, JA. "The obesity paradox, extreme obesity, and long-term outcomes in older adults with ST-segment elevation myocardial infarction: results from the NCDR." European heart journal. Quality of care & clinical outcomes 3, no. 3 (July 2017): 183-191.

PMID
28838094
Full Text

Alexander, KP. "Low-Hanging Fruit for a Healthy Old Age." Journal of the American College of Cardiology 69, no. 25 (June 2017): 3027-3028.

PMID
28641791
Full Text

Fanaroff, AC, James, SK, Weisz, G, Prather, K, Anstrom, KJ, Mark, DB, Ben-Yehuda, O, Alexander, KP, Stone, GW, and Ohman, EM. "Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial." Journal of the American College of Cardiology 69, no. 18 (May 2017): 2304-2313.

PMID
28473136
Full Text

Guimarães, PO, Lopes, RD, Stevens, SR, Zimerman, A, Wruck, L, James, SK, Haque, G, Giraldez, RRCV, Alexander, JH, and Alexander, KP. "Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection." Journal of the American Heart Association 6, no. 4 (April 24, 2017).

PMID
28438739
Full Text

Alexander, KP. "Assessing the Utility of Transcatheter Aortic Valve Replacement." JAMA cardiology 2, no. 4 (April 2017): 416-417.

PMID
28146227
Full Text

Pages