Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Pishko, AM, Fardin, S, Lefler, DS, Paydary, K, Vega, R, Arepally, GM, Crowther, M, Rice, L, Cines, DB, and Cuker, A. "Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia." Blood Advances 2, no. 22 (November 2018): 3155-3162.

PMID
30463915
Full Text

Cuker, A, Arepally, GM, Chong, BH, Cines, DB, Greinacher, A, Gruel, Y, Linkins, LA, Rodner, SB, Selleng, S, Warkentin, TE, Wex, A, Mustafa, RA, Morgan, RL, and Santesso, N. "American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia." Blood Advances 2, no. 22 (November 2018): 3360-3392. (Review)

PMID
30482768
Full Text

Khandelwal, S, Ravi, J, Rauova, L, Johnson, A, Lee, GM, Gilner, JB, Gunti, S, Notkins, AL, Kuchibhatla, M, Frank, M, Poncz, M, Cines, DB, and Arepally, GM. "Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway." Blood (October 11, 2018).

PMID
30309891
Full Text

Rauova, L, Arepally, G, Poncz, M, and Cines, DB. "Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT)." Autoimmunity Reviews 17, no. 10 (October 2018): 1046-1052. (Review)

PMID
30103043
Full Text

Gollomp, K, Kim, M, Johnston, I, Hayes, V, Welsh, J, Arepally, GM, Kahn, M, Lambert, MP, Cuker, A, Cines, DB, Rauova, L, Kowalska, MA, and Poncz, M. "Neutrophil accumulation and NET release contribute to thrombosis in HIT." Jci Insight 3, no. 18 (September 20, 2018).

PMID
30232279
Full Text

Dai, J, Madeeva, D, Hayes, V, Ahn, HS, Tutwiler, V, Arepally, GM, Cines, DB, Poncz, M, and Rauova, L. "Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia." Blood 132, no. 7 (August 2018): 727-734.

PMID
29914979
Full Text

Khandelwal, S, Johnson, AM, Liu, J, Keire, D, Sommers, C, Ravi, J, Lee, GM, Lambris, JD, Reis, ES, and Arepally, GM. "Novel Immunoassay for Complement Activation by PF4/Heparin Complexes." Thrombosis and Haemostasis 118, no. 8 (August 2018): 1484-1487.

PMID
29960275
Full Text

Onwuemene, OA, Grambow, SC, Patel, CB, Mentz, RJ, Milano, CA, Rogers, JG, Metjian, AD, Arepally, GM, and Ortel, TL. "Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study." Journal of Clinical Apheresis 33, no. 4 (August 2018): 469-479.

PMID
29524240
Full Text

Gunaratne, R, Kumar, S, Frederiksen, JW, Stayrook, S, Lohrmann, JL, Perry, K, Bompiani, KM, Chabata, CV, Thalji, NK, Ho, MD, Arepally, G, Camire, RM, Krishnaswamy, S, and Sullenger, BA. "Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass." Nature Biotechnology 36, no. 7 (August 2018): 606-613.

PMID
29863725
Full Text

Haile, LA, Rao, R, Polumuri, SK, Arepally, GM, Keire, DA, Verthelyi, D, and Sommers, CD. "PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses." Thrombosis Research 159 (November 2017): 39-47.

PMID
28968537
Full Text

Pages