Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Durá-Ferrandis, E, Mandelblatt, JS, Clapp, J, Luta, G, Luta, G, Faul, L, Kimmick, G, Cohen, HJ, Yung, RL, and Hurria, A. "Personality, coping, and social support as predictors of long-term quality-of-life trajectories in older breast cancer survivors: CALGB protocol 369901 (Alliance)." Psycho-oncology 26, no. 11 (November 2017): 1914-1921.

PMID
28219113
Full Text

Foster, JC, Le-Rademacher, JG, Feliciano, JL, Gajra, A, Seisler, DK, DeMatteo, R, Lafky, JM, Hurria, A, Muss, HB, Cohen, HJ, and Jatoi, A. "Comparative "nocebo effects" in older patients enrolled in cancer therapeutic trials: Observations from a 446-patient cohort." Cancer 123, no. 21 (November 2017): 4193-4198.

PMID
28700816
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Bluethmann, SM, Alfano, CM, Clapp, JD, Luta, G, Small, BJ, Hurria, A, Cohen, HJ, Sugarman, S, B Muss, H, Isaacs, C, and Mandelblatt, JS. "Cognitive function and discontinuation of adjuvant hormonal therapy in older breast cancer survivors: CALGB 369901 (Alliance)." Breast cancer research and treatment 165, no. 3 (October 2017): 677-686.

PMID
28653250
Full Text

Stinchcombe, TE, Zhang, Y, Vokes, EE, Schiller, JH, Bradley, JD, Kelly, K, Curran, WJ, Schild, SE, Movsas, B, Clamon, G, Govindan, R, Blumenschein, GR, Socinski, MA, Ready, NE, Akerley, WL, Cohen, HJ, Pang, HH, and Wang, X. "Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 35, no. 25 (September 2017): 2885-2892.

PMID
28493811
Full Text

King, KE, Fillenbaum, GG, and Cohen, HJ. "A Cumulative Deficit Laboratory Test-based Frailty Index: Personal and Neighborhood Associations." Journal of the American Geriatrics Society 65, no. 9 (September 2017): 1981-1987.

PMID
28665517
Full Text

Cohen, HJ, Roy, CN, and Snyder, PJ. "Redefining Unexplained Anemia in Elderly-Reply." JAMA internal medicine 177, no. 9 (September 2017): 1395-.

PMID
28873192
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Belsky, DW, Caspi, A, Cohen, HJ, Kraus, WE, Ramrakha, S, Poulton, R, and Moffitt, TE. "Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan." Aging cell 16, no. 4 (August 2017): 644-651.

PMID
28401731
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Mandelblatt, JS, Cai, L, Luta, G, Kimmick, G, Clapp, J, Isaacs, C, Pitcher, B, Barry, W, Winer, E, Sugarman, S, Hudis, C, Muss, H, Cohen, HJ, and Hurria, A. "Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance)." Breast cancer research and treatment 164, no. 1 (July 2017): 107-117.

PMID
28364214
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Kimmick, GG, Major, B, Clapp, J, Sloan, J, Pitcher, B, Ballman, K, Barginear, M, Freedman, RA, Artz, A, Klepin, HD, Lafky, JM, Hopkins, J, Winer, E, Hudis, C, Muss, H, Cohen, H, Jatoi, A, Hurria, A, and Mandelblatt, J. "Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503)." Breast cancer research and treatment 163, no. 2 (June 2017): 391-398.

PMID
28283904
Full Text

Roy, CN, Snyder, PJ, Stephens-Shields, AJ, Artz, AS, Bhasin, S, Cohen, HJ, Farrar, JT, Gill, TM, Zeldow, B, Cella, D, Barrett-Connor, E, Cauley, JA, Crandall, JP, Cunningham, GR, Ensrud, KE, Lewis, CE, Matsumoto, AM, Molitch, ME, Pahor, M, Swerdloff, RS, Cifelli, D, Hou, X, Resnick, SM, Walston, JD, Anton, S, Basaria, S, Diem, SJ, Wang, C, Schrier, SL, and Ellenberg, SS. "Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial." JAMA internal medicine 177, no. 4 (April 2017): 480-490.

PMID
28241237
Full Text

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