Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Goode, AP, Cleveland, B, Schwartz, T, George, SZ, Kraus, VB, Gracely, R, Chen, J, Jordan, JM, and Golightly, YM. "Demographic and Clinical Characteristics Reflect Differences in Osteoarthritis Phenotypes of the Lumbar Spine: The Johnston County Osteoarthritis Project.": WILEY, September 1, 2018.

Scholars@Duke

Goode, AP, Cleveland, B, Schwartz, T, George, SZ, Kraus, VB, Gracely, R, Chen, J, Jordan, JM, and Golightly, YM. "Demographic and Clinical Characteristics Reflect Differences in Osteoarthritis Phenotypes of the Lumbar Spine: The Johnston County Osteoarthritis Project.": WILEY, September 1, 2018.

Scholars@Duke

Longobardi, L, Jordan, JM, Shi, XA, Renner, JB, Schwartz, TA, Nelson, AE, Barrow, DA, Kraus, VB, and Spagnoli, A. "Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project." Osteoarthritis and Cartilage 26, no. 9 (September 2018): 1257-1261.

PMID
29723633
Full Text

Huang, Z, Huang, C, Xie, J, Ma, J, Cao, G, Huang, Q, Shen, B, Byers Kraus, V, and Pei, F. "Analysis of a large data set to identify predictors of blood transfusion in primary total hip and knee arthroplasty." Transfusion 58, no. 8 (August 25, 2018): 1855-1862.

PMID
30145838
Full Text

Huang, ZY, Perry, E, Huebner, JL, Katz, B, Li, Y-J, and Kraus, VB. "Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial." Osteoarthritis and Cartilage (August 23, 2018).

PMID
30144513
Full Text

Watt, FE, Corp, N, Kingsbury, SR, Frobell, R, Englund, M, Felson, DT, Levesque, M, Majumdar, S, Wilson, C, Beard, DJ, Lohmander, LS, Kraus, VB, Roemer, F, Conaghan, PG, Mason, DJ, and Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group, . "Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury." Osteoarthritis and Cartilage (August 18, 2018).

PMID
30125638
Full Text

Lv, Y-B, Liu, S, Yin, Z-X, Gao, X, Kraus, VB, Mao, C, Yuan, J-Q, Zhang, J, Luo, J-S, Chen, H-S, Zeng, Y, and Shi, X-M. "Associations of Body Mass Index and Waist Circumference with 3-Year All-Cause Mortality Among the Oldest Old: Evidence from a Chinese Community-Based Prospective Cohort Study." Journal of the American Medical Directors Association 19, no. 8 (August 2018): 672-678.e4.

PMID
29807748
Full Text

Yuan, J-Q, Lv, Y-B, Chen, H-S, Gao, X, Yin, Z-X, Wang, W-T, Kraus, VB, Luo, J-S, Wang, J-N, Zeng, Y, Mao, C, and Shi, X-M. "Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study." Journal of the American Medical Directors Association (July 13, 2018).

PMID
30017702
Full Text

Zuo, X, Luciano, A, Pieper, CF, Bain, JR, Kraus, VB, Kraus, WE, Morey, MC, and Cohen, HJ. "Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults." Journal of the American Geriatrics Society 66, no. 7 (July 2018): 1353-1359.

PMID
29738072
Full Text

King, JD, Rowland, G, Villasante Tezanos, AG, Warwick, J, Kraus, VB, Lattermann, C, and Jacobs, CA. "Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State." Cartilage (July 2018): 1947603518790009-null.

PMID
30033738
Full Text

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