Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Lv, Y-B, Liu, S, Yin, Z-X, Gao, X, Kraus, VB, Mao, C, Yuan, J-Q, Zhang, J, Luo, J-S, Chen, H-S, Zeng, Y, and Shi, X-M. "Associations of Body Mass Index and Waist Circumference with 3-Year All-Cause Mortality Among the Oldest Old: Evidence from a Chinese Community-Based Prospective Cohort Study." Journal of the American Medical Directors Association 19, no. 8 (August 2018): 672-678.e4.

PMID
29807748
Full Text

Yuan, J-Q, Lv, Y-B, Chen, H-S, Gao, X, Yin, Z-X, Wang, W-T, Kraus, VB, Luo, J-S, Wang, J-N, Zeng, Y, Mao, C, and Shi, X-M. "Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study." Journal of the American Medical Directors Association (July 13, 2018).

PMID
30017702
Full Text

King, JD, Rowland, G, Villasante Tezanos, AG, Warwick, J, Kraus, VB, Lattermann, C, and Jacobs, CA. "Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State." Cartilage (July 2018): 1947603518790009-null.

PMID
30033738
Full Text

Golightly, YM, Hannan, MT, Nelson, AE, Hillstrom, HJ, Cleveland, RJ, Kraus, VB, Schwartz, TA, Goode, AP, Flowers, P, Renner, JB, and Jordan, JM. "Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort." Arthritis Care & Research (June 28, 2018).

PMID
29953742
Full Text

Bartlett, DB, Willis, LH, Slentz, CA, Hoselton, A, Kelly, L, Huebner, JL, Kraus, VB, Moss, J, Muehlbauer, MJ, Spielmann, G, Kraus, WE, Lord, JM, and Huffman, KM. "Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study." Arthritis Research & Therapy 20, no. 1 (June 14, 2018): 127-null.

PMID
29898765
Full Text

Lv, Y-B, Gao, X, Yin, Z-X, Chen, H-S, Luo, J-S, Brasher, MS, Kraus, VB, Li, T-T, Zeng, Y, and Shi, X-M. "Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study." Bmj (Clinical Research Ed.) 361 (June 5, 2018): k2158-null.

PMID
29871897
Full Text

Kraus, VB. "Biomarkers as drug development tools: discovery, validation, qualification and use." Nature Reviews. Rheumatology 14, no. 6 (June 2018): 354-362. (Review)

PMID
29760435
Full Text

Zuo, X, Luciano, A, Pieper, CF, Bain, JR, Kraus, VB, Kraus, WE, Morey, MC, and Cohen, HJ. "Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults." Journal of the American Geriatrics Society (May 8, 2018).

PMID
29738072
Full Text

Deveza, LA, Kraus, VB, Collins, JE, Guermazi, A, Roemer, FW, Nevitt, MC, and Hunter, DJ. "Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative." Scandinavian Journal of Rheumatology 47, no. 3 (May 2018): 235-242.

PMID
28929915
Full Text

Leung, YY, Haaland, B, Huebner, JL, Wong, SBS, Tjai, M, Wang, C, Chowbay, B, Thumboo, J, Chakraborty, B, Tan, MH, and Kraus, VB. "Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial." Osteoarthritis and Cartilage 26, no. 5 (May 2018): 631-640.

PMID
29426008
Full Text

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