Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7028, Durham, NC 27705
Phone (919) 668-8820
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

Granieri, MA, Webster, GD, and Peterson, AC. "Author Reply." Urology 91 (May 2016): 207-. (Letter)

PMID
27083938
Full Text

Selker, HP, Buse, JB, Califf, RM, Carter, R, Cooper, DM, Davis, J, Ford, DE, Galassetti, P, Guay-Woodford, L, Huggins, GS, Kasper, A, Kieburtz, K, Kirby, A, Klein, AK, Kline, J, O' Neill, RT, Rape, M, Reichgott, DJ, Rojevsky, S, Rosenthal, GE, Rubinstein, EP, Shepherd, A, Stacy, M, Terrin, N, Wallace, M, and Welch, L. "CTSA Consortium Consensus Scientific Review Committee (SRC) Working Group Report on the SRC Processes." Clinical and translational science 8, no. 6 (December 2015): 623-631.

PMID
26184433
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Preiss, D, Thomas, LE, Wojdyla, DM, Haffner, SM, Gill, JMR, Yates, T, Davies, MJ, Holman, RR, McMurray, JJ, Califf, RM, Kraus, WE, and NAVIGATOR Investigators, . "Prospective relationships between body weight and physical activity: an observational analysis from the NAVIGATOR study." BMJ open 5, no. 8 (August 14, 2015): e007901-.

PMID
26275900
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Kelly, JP, Mentz, RJ, Hasselblad, V, Ezekowitz, JA, Armstrong, PW, Zannad, F, Felker, GM, Califf, RM, O'Connor, CM, and Hernandez, AF. "Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF)." American heart journal 170, no. 2 (August 2015): 298-305.

PMID
26299227
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Khazanie, P, Heizer, GM, Hasselblad, V, Armstrong, PW, Califf, RM, Ezekowitz, J, Dickstein, K, Levy, WC, McMurray, JJV, Metra, M, Tang, WHW, Teerlink, JR, Voors, AA, O'Connor, CM, Hernandez, AF, and Starling, R. "Predictors of clinical outcomes in acute decompensated heart failure: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure outcome models." American heart journal 170, no. 2 (August 2015): 290-297.

PMID
26299226
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ter Maaten, JM, Dunning, AM, Valente, MAE, Damman, K, Ezekowitz, JA, Califf, RM, Starling, RC, van der Meer, P, O'Connor, CM, Schulte, PJ, Testani, JM, Hernandez, AF, Tang, WHW, and Voors, AA. "Diuretic response in acute heart failure-an analysis from ASCEND-HF." American heart journal 170, no. 2 (August 2015): 313-321.

PMID
26299229
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Yates, T, Davies, MJ, Haffner, SM, Schulte, PJ, Thomas, L, Huffman, KM, Bales, CW, Preiss, D, Califf, RM, Holman, RR, McMurray, JJV, Bethel, MA, Tuomilehto, J, and Kraus, WE. "Physical activity as a determinant of fasting and 2-h post-challenge glucose: a prospective cohort analysis of the NAVIGATOR trial." Diabetic medicine : a journal of the British Diabetic Association 32, no. 8 (August 2015): 1090-1096.

PMID
25818859
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Cannon, CP, Blazing, MA, Giugliano, RP, McCagg, A, White, JA, Theroux, P, Darius, H, Lewis, BS, Ophuis, TO, Jukema, JW, De Ferrari, GM, Ruzyllo, W, De Lucca, P, Im, K, Bohula, EA, Reist, C, Wiviott, SD, Tershakovec, AM, Musliner, TA, Braunwald, E, Califf, RM, and IMPROVE-IT Investigators, . "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes." The New England journal of medicine 372, no. 25 (June 3, 2015): 2387-2397.

PMID
26039521
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Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American heart journal 169, no. 6 (June 1, 2015): 743-750. (Review)

Full Text

Washam, JB, Stevens, SR, Lokhnygina, Y, Halperin, JL, Breithardt, G, Singer, DE, Mahaffey, KW, Hankey, GJ, Berkowitz, SD, Nessel, CC, Fox, KAA, Califf, RM, Piccini, JP, Patel, MR, and ROCKET AF Steering Committee and Investigators, . "Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)." Lancet (London, England) 385, no. 9985 (June 2015): 2363-2370.

PMID
25749644
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