Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Mohammad, S, Clowse, MEB, Eudy, AM, and Criscione-Schreiber, LG. "Examination of Hydroxychloroquine Use and Hemolytic Anemia in G6PDH-Deficient Patients." Arthritis care & research 70, no. 3 (March 2018): 481-485.

PMID
28556555
Full Text

Eudy, AM, McDaniel, G, and Clowse, MEB. "Pregnancy in rheumatoid arthritis: a retrospective study." Clinical rheumatology 37, no. 3 (March 2018): 789-794.

PMID
29222600
Full Text

Palmsten, K, Rolland, M, Hebert, MF, Clowse, MEB, Schatz, M, Xu, R, and Chambers, CD. "Patterns of prednisone use during pregnancy in women with rheumatoid arthritis: Daily and cumulative dose." Pharmacoepidemiology and drug safety (February 28, 2018).

PMID
29488292
Full Text

Birru Talabi, M, Clowse, MEB, Schwarz, EB, Callegari, LS, Moreland, L, and Borrero, S. "Family Planning Counseling for Women With Rheumatic Diseases." Arthritis care & research 70, no. 2 (February 2018): 169-174. (Review)

PMID
28437837
Full Text

Clowse, ME, Förger, F, Hwang, C, Thorp, J, Dolhain, RJ, van Tubergen, A, Shaughnessy, L, Simpson, J, Teil, M, Toublanc, N, Wang, M, and Hale, TW. "Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study." Annals of the rheumatic diseases 76, no. 11 (November 2017): 1890-1896.

PMID
28814432
Full Text

Eudy, AM, Siega-Riz, AM, Engel, SM, Franceschini, N, Howard, AG, Clowse, MEB, and Petri, M. "Gestational weight gain in women with systemic lupus erythematosus." Lupus 26, no. 6 (May 2017): 623-632.

PMID
27703053
Full Text

Machen, L, and Clowse, MEB. "Vasculitis and Pregnancy." Rheumatic diseases clinics of North America 43, no. 2 (May 2017): 239-247. (Review)

PMID
28390566
Full Text

Clowse, MEB, Wallace, DJ, Furie, RA, Petri, MA, Pike, MC, Leszczyński, P, Neuwelt, CM, Hobbs, K, Keiserman, M, Duca, L, Kalunian, KC, Galateanu, C, Bongardt, S, Stach, C, Beaudot, C, Kilgallen, B, Gordon, C, and EMBODY Investigator Group, . "Efficacy and Safety of Epratuzumab in Moderately to Severely Active Systemic Lupus Erythematosus: Results From Two Phase III Randomized, Double-Blind, Placebo-Controlled Trials." Arthritis & rheumatology (Hoboken, N.J.) 69, no. 2 (February 2017): 362-375.

PMID
27598855
Full Text

Eudy, AM, Jayasundara, M, Haroun, T, Neil, L, James, AH, and Clowse, MEB. "Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus." Lupus (January 2017): 961203317720525-.

PMID
28699378
Full Text

Yazdany, J, Bansback, N, Clowse, M, Collier, D, Law, K, Liao, KP, Michaud, K, Morgan, EM, Oates, JC, Orozco, C, Reimold, A, Simard, JF, Myslinski, R, and Kazi, S. "Rheumatology Informatics System for Effectiveness: A National Informatics-Enabled Registry for Quality Improvement." Arthritis care & research 68, no. 12 (December 2016): 1866-1873.

PMID
27696755
Full Text

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