Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Lyles, KW. "Have We Learned How to Use Bisphosphonates Yet?." Journal of the American Geriatrics Society 65, no. 9 (September 2017): 1902-1903.

PMID
28555749
Full Text

Abderhalden, L, Weaver, FM, Bethel, M, Demirtas, H, Burns, S, Svircev, J, Hoenig, H, Lyles, K, Miskevics, S, and Carbone, LD. "Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues." Osteoporosis International 28, no. 7 (July 2017): 2261-2262.

Full Text

Abderhalden, L, Weaver, FM, Bethel, M, Demirtas, H, Burns, S, Svircev, J, Hoenig, H, Lyles, K, Miskevics, S, and Carbone, LD. "Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders." Osteoporosis International 28, no. 3 (March 2017): 925-934.

Full Text

Bethel, M, Weaver, FM, Bailey, L, Miskevics, S, Svircev, JN, Burns, SP, Hoenig, H, Lyles, K, and Carbone, LD. "Risk factors for osteoporotic fractures in persons with spinal cord injuries and disorders." Osteoporosis International 27, no. 10 (October 2016): 3011-3021.

Full Text

Lee, RH, Pearson, M, Lyles, KW, Jenkins, PW, and Colon-Emeric, C. "Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture." Rural and remote health 16, no. 1 (January 7, 2016): 3440-.

PMID
26745338
Scholars@Duke

Colón-Emeric, C, Pieper, CF, Grubber, J, Van Scoyoc, L, Schnell, ML, Van Houtven, CH, Pearson, M, Lafleur, J, Lyles, KW, and Adler, RA. "Correlation of hip fracture with other fracture types: Toward a rational composite hip fracture endpoint." Bone 81 (December 2015): 67-71.

PMID
26151123
Full Text

Singer, FR, Bone, HG, Hosking, DJ, Lyles, KW, Reid, IR, and Siris, ES. "Response to letter by Ralston et al." The Journal of clinical endocrinology and metabolism 100, no. 6 (June 2015): L47-L48. (Letter)

PMID
26047081
Full Text

Singer, FR, Bone, HG, Hosking, DJ, Lyles, KW, Reid, IR, and Siris, ES. "Response to letter by Ralston et al." The Journal of Clinical Endocrinology & Metabolism 100, no. 6 (June 2015): L47-L48.

Full Text

Singer, FR, Bone, HG, Hoskings, DJ, Lyles, KW, Reid, IR, and Siris, ES. "Response to letter." The Journal of Clinical Endocrinology and Metabolism 100, no. 5 (May 2015): L38-. (Letter)

PMID
25955331
Full Text

Singer, FR, Bone, HG, Hosking, DJ, Lyles, KW, Murad, MH, Reid, IR, and Siris, ES. "Response to the letter by Asik M., et al." The Journal of Clinical Endocrinology and Metabolism 100, no. 4 (April 2015): L36-. (Letter)

PMID
25844773
Full Text

Pages