Liddle Laboratory

Rodger Liddle, MD, Primary Investigator

Rodger Liddle, MD
Professor of Medicine

Member
Duke Institute for Brain Sciences
Duke Cancer Institute

Location:
Room 1033A, Genome Science Research Building-1
905 S. LaSalle Street
Duke University Medical Center
Durham, NC 27710

Campus Mail:
Box 103859

Contact:
919-681-6380
rodger.liddle@duke.edu

Education

B.S., University of Utah, 1972
M.D., Vanderbilt University, 1978
Internship (Medicine), University of California, San Francisco, 1979
Residency (Medicine), University of California, San Francisco, 1981
Fellowship (Gastroenterology), University of California, San Francisco, 1984

Research Interests

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Grants

“Pathogenic Mechanisms of Pancreatitis” - NIH
“Mechanisms regulating gastrointestinal hormone secretion” - NIH
“Receptor regulation of CCK cell function” - NIH
“Gut neuroendocrine cell signaling and obesity” - VA

Lab Members

Rodger Liddle, MD 
Primary Investigator

Rashmi Chandra, PhD 
Senior Research Scientist

Joelle Romac, PhD
Senior Research Scientist

Rafiq Shahid, MD
Research Scientist

Stephanie King, MS
Research Scientist

Steven R. Vigna, PhD
Associate Professor of Cell Biology and Medicine

Lihua Ye
Postdoctoral Fellow

Former Lab Members

Diego Bohorquez, PhD
Christi Ballard
Bryant Beebe
Yu Wang, PhD
Alan Erdmann, MD
Fariha Haque
​Mash Haque
Anthony Therattil
Alex Kreger
Supriya Davis
Brian Fee, PhD
Barry Gooch, PhD
Lee Ann Samsa
M. F. Majeed
John Humphrey, MD
Marc Noble, MD
Michael Peyton, PhD
Jaimie Nathan, MD
Akash Patel, MD
Lee Ann Scott
Jasmine Hayes
Laine Hurst
Ala Sharara, MD
Nicholas Snow, MD
Yoshifumi Higashimoto, MD, PhD
Ernest Bouras, MD
Paul Yudelman, MD
Shuji Kanayama, MD, PhD
Tom Geracioti, MD
Robert Rushakoff, MD
Randy Taplitz, MD
Jacqueline Carter
Carol Conrad