Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Wertman, V, Rudemiller, NP, McMahon, TJ, Shenoy, SK, Miller, FJ, Crowley, SD, Freedman, NJ, and Stiber, JA. "Drebrin regulates angiotensin II-induced aortic remodelling." Cardiovascular Research 114, no. 13 (November 2018): 1806-1815.

PMID
29931051
Full Text

Giangrande, PH, Miller, FJ, and Thiel, WH. "VSMC Specific Aptamer Ligands for the Next Generation of DES to Prevent Neointimal Formation." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018.

Scholars@Duke

Leisegang, MS, Fork, C, Josipovic, I, Richter, FM, Preussner, J, Hu, J, Miller, MJ, Epah, J, Hofmann, P, Günther, S, Moll, F, Valasarajan, C, Heidler, J, Ponomareva, Y, Freiman, TM, Maegdefessel, L, Plate, KH, Mittelbronn, M, Uchida, S, Künne, C, Stellos, K, Schermuly, RT, Weissmann, N, Devraj, K, Wittig, I, Boon, RA, Dimmeler, S, Pullamsetti, SS, Looso, M, Miller, FJ, and Brandes, RP. "Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function." Circulation 136, no. 1 (July 2017): 65-79.

PMID
28351900
Full Text

Urak, KT, Miller, FJ, and Giangrande, P. "Treatment of Sepsis by Neutralization of Extracellular Histones with Nucleic Acid Aptamers." May 2017.

Scholars@Duke

Leisegang, MS, Fork, C, Josipovic, I, Richler, F, Preussner, J, Millers, MJ, Epah, J, Hofmann, P, Anther, S, Valasarajan, C, Moll, F, Heidler, J, Ponomareva, Y, Maegdefesser, L, Uchida, S, Kunne, C, Sleilos, K, Schermuly, RT, Weissmann, N, Devraj, K, Wittig, I, Boon, RA, Dimmeler, S, Pullamsetti, SS, Looso, M, Jr, MFJ, and Brandes, RP. "LncRNA MANTIS facilitates endothelial angiogenic function." March 2017.

Scholars@Duke

Schickling, BM, Takapoo, M, Khera, R, and Miller, FJ. "Circulating EGF-Like Ligands in Obesity Increase Neointimal Formation through Upregulation of NADPH Oxidase 1." November 2016.

Full Text

Thiel, WH, Esposito, CL, Dickey, DD, Dassie, JP, Long, ME, Adam, J, Streeter, J, Schickling, B, Takapoo, M, Flenker, KS, Klesney-Tait, J, Franciscis, VD, Miller, FJ, and Giangrande, PH. "Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation." Molecular therapy : the journal of the American Society of Gene Therapy 24, no. 4 (April 2016): 779-787.

PMID
26732878
Full Text

Thiel, WH, Esposito, CL, Dickey, DD, Dassie, JP, Long, ME, Adam, J, Streeter, J, Schickling, B, Takapoo, M, Flenker, KS, Klesney-Tait, J, Franciscis, VD, Miller, FJ, and Giangrande, PH. "Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation." Molecular therapy : the journal of the American Society of Gene Therapy 24, no. 4 (April 2016): 779-787.

PMID
28135581
Full Text

Gimenez, M, Schickling, BM, Lopes, LR, and Miller, FJ. "Nox1 in cardiovascular diseases: regulation and pathophysiology." Clinical Science (London, England : 1979) 130, no. 3 (February 2016): 151-165. (Review)

PMID
26678171
Full Text

Miller, FJ. "Nox4 NADPH oxidase: emerging from the veil of darkness." European heart journal 36, no. 48 (December 2015): 3457-3459.

PMID
26429798
Full Text

Pages