Active NIH grants

Medicine faculty and trainees receive significant research and career-development support from the National Institutes of Health. The tables below list faculty with current grants from R and K mechanisms.

Our faculty also have 47 P grants and 93 U grants.

These tables were last updated January 2018.

Research Programs

Investigator Division Project Grant
Christopher Holley Cardiology Role of snoRNAs in regulation of cardiac hypertrophy R03
Christopher Kontos Cardiology Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease R01
Deepak Voora Cardiology Development Of Prognostic Platelet RNA Biomarkers To Tailor Antiplatelet Therapy R01
Eric Velazquez Cardiology STICHES R01

Howard A. Rockman

Cardiology

Mechanisms of Maladaptation in Heart Failure

R01

Igor Klem

Cardiology

Medical Images, HTML5, and Clinical Trial Remote Collaboration

R42
Jonathan A. Stiber Cardiology Role of Drebrin in Atherosclerosis R01
Jonathan A. Stiber Cardiology Role of Drebrin in Vascular Smooth Muscle Remodeling R01
Michael D. Gunn Cardiology Generation of Zika virus-specific recombinant antibodies R21
Michael D. Gunn Cardiology Development of anti-Salmonella Single-chain Abs as serum diagnostics R33
Neil J. Freedman Cardiology Anti-atherogenic Mechanisms of the Dual Rho-GEF Kalirin R01
Paul B. Rosenberg Cardiology STIM1 and metabolic flexibility R01
Robert J. Lefkowitz Cardiology Molecular Regulation of Cardiovascular 7 TM Receptors R01

Sudarshan Rajagopal

Cardiology

Biasing CXCR3 Signaling to Modulate the Inflammatory Response

R01

Sudarshan Rajagopal

Cardiology

Beta-Arrestin Regulation of VEGFR3 Signaling in Pulmonary Hypertension

R03
Sudha Shenoy Cardiology Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20 R01
Svati H. Shah Cardiology A Personalized Metabolomic Approach to Human Obesity and Weight Loss R01
Svati H. Shah Cardiology Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV R56
Dorothy Sipkins Cell Therapy

Defining the Rules of Breast Cancer Cell Traffic Through Bone

R01
Nelson J. Chao Cell Therapy

Patient-centered home-based hematopoietic stem cell transplantation

R01
Sandeep Dave Cell Therapy

Defining the Functional Role of Mutations in Diffuse Large B cell Lymphoma

R01
Sandeep Dave Cell Therapy

Understanding the Context-Dependent Roles of Mutations in Lymphoma

R01

Stefanie Sarantopoulos

Cell Therapy

Improving Outcomes Assessment in cGVHD

R01
Stefanie Sarantopoulos Cell Therapy

Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD

R01

Yiping Yang

Cell Therapy

T memory stem cells in cancer

R01

Yiping Yang

Cell Therapy

Novel Strategies for Cancer Immunotherapy in Stem Cell Transplant

R01
Yubin Kang  Cell Therapy

Targeting sphingosine kinase 2 for the treatment of multiple myeloma

R01
Yubin Kang  Cell Therapy

Clinical Trial of ABC294640 in Patients with Refractory Multiple Myeloma

R44
Mary E. Klotman Chair's Office

The Genitourinary Tract as a compartment and reservoir for HIV

R01
Laurent K. Verkoczy DHVI Defining parameters to induce breadth in knockin mice expressing HIV bnAb precursors R01
David D'Alessio Endocrinology INCRETIN ACTION IN PHYSIOLOGY AND DIABETES R01
Deborah Muoio Endocrinology Role of Carnitine Acetyltransferase in Mitochondrial and Metabolic Function R01
Jenny Tong Endocrinology The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes R01
Mark Herman Endocrinology The Role of ChREBP in Fructose Induced Metabolic Disease R01
Matthew D. Hirschey Endocrinology Ethanol-induced Protein Acylation Regulates Metabolism R01
Matthew D. Hirschey Endocrinology Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease R01
Richard H. Lee Endocrinology Metabolomics of low-trauma fracture among older women with diabetes R03
Anna Mae Diehl Gastroenterology Hedgehog Signaling and Adult Liver Regeneration R01
Anna Mae Diehl Gastroenterology TNF Alpha and Recovery from Alchoholic Liver Injury R37
Diego Bohorquez Gastroenterology Tasting Gut Bacteria R03
Rodger A. Liddle Gastroenterology Pathogenic Mechanisms of Pancreatitis R01
Rodger A. Liddle Gastroenterology The role of gut endocrine cells in Parkinson's Disease R01
Rodger A. Liddle Gastroenterology Receptor Regulation of CCK Cell Function R01
Wei Chen Gastroenterology Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy R01
Jennifer J. St. Clair Russell General Internal Medicine Using Mixed Methods to Explore Barriers and Facilitators to Nephrologist-Initiated Discussions about Palliative Care R03

Keisha Bentley-Edwards

General Internal Medicine

Religion, Spirituality and CVD Risks: A Focus on African Americans

R01

Laura M. Beskow General Internal Medicine Beyond Data Security: Promoting Confidentiality and Advancing Science R01
Leigh Boulware General Internal Medicine Transplant Social Worker Support for Live Kidney Donation in African Americans R01
Leigh Boulware General Internal Medicine Potential Barriers and Facilitators to Living Donor Kidney Transplantation Among Black Americans R01
Susanne B. Haga General Internal Medicine Pharmacogenetic Testing: Challenges of Clinical Integration R01
Susanne B. Haga General Internal Medicine Summer Scholars Program in Genome Sciences and Medicine R25
Christopher B. Bowling  Geriatrics Sustained blood pressure control and progression of multimorbidity R01
Heather E. Whitson Geriatrics Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration R01
Kimberly Johnson Geriatrics Implementing Best Practice in Palliative Care R18
J. Brice Weinberg Hematology Nitric Oxide and Microvascular Dysfunction in Severe Malaria R01
Marilyn J. Telen Hematology Factor XIII and Fibrinogen: Mechanisms of Genetic Risk in SCD-Related Priapism R21
Nirmish R. Shah Hematology Use of Mobile Technology to Improve Acute Care Utilization in Sickle Cell Disease R21
Andrew Alspaugh Infectious Diseases Coordinated Regulation of Virulence Genes in C. neoformans R01
Deverick J. Anderson Infectious Diseases Prevention of Surgical Site Infection using Statistical Process Control Charts R01
Feng Gao Infectious Diseases Dissection of polyreactivity and neutralization activity of HIV-1 Abs R01
Greg Gray Infectious Diseases Swine Influenza Virus Transmission in Confined Animal Feeding Operations, China R01
John Perfect Infectious Diseases Pathobiology of C. neoformans in the Central Nervous System R01
Megan E. Reller Infectious Diseases RICKETTSIAL INFECTIONS IN MALAYSIA R03

Micah T. McClain

Infectious Diseases

Host-derived biomarker signatures to differentiate acute viral, bacterial, and fungal infection

R21
Steve Taylor Infectious Diseases Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites R21
Steve Taylor  Infectious Diseases

New approaches for malaria surveillance in an era of changing malaria transmission: the potential of pregnant women

R01
Steve Taylor  Infectious Diseases

Malaria chemoprevention in children with sickle cell anemia in Western Kenya

R01
Susanna Naggie Infectious Diseases Identification of Novel Bioactive Lipid Metabolites for Predicting Liver-related Outcomes in Persons Co-Infected with HIV and HCV R01
Vance G. Fowler Jr. Infectious Diseases Host Susceptibility to S. aureus R01
Vivian H. Chu Infectious Diseases Bridging the Gap to Enhance Clinical Research Program (BIGGER) R25
Vivian H. Chu Infectious Diseases Optimizing treatment for E. faecalis infective endocarditis: ampicillin plus ceftriaxone versus ampicillin plus gentamicin R34
Wendy A. Prudhomme - O'Meara Infectious Diseases Innovative partnership to target antimalarial subsidies in the retail sector R01
Wendy A. Prudhomme - O'Meara Infectious Diseases Spatial Scales of Plasmodium Falciparum Generations; Implications for Elimination R21

Steven Patierno

Medical Oncology

Race-related alternative splicing: novel targets in prostate cancer

R01

Syed Y. Zafar

Medical Oncology

PAPNavigator STTR (Fast-Track)

R42
Allison E. Ashley-Koch Nephrology Transcriptomic, therapeutic and genetic investigations of sickle cell nephropathy R01
Julia Scialla Nephrology Integrated Mineral Metabolism Treatment Strategies in Patients on Dialysis R01
Mary H. Foster Nephrology

Gene-Environment Collaboration in Autoimmune Disease

R01
Myles Wolf Nephrology

Role of FGF23 in Mineral Metabolism Across the Spectrum of Chronic Kidney Disease

R01

Myles Wolf Nephrology FGF23 and Cardiovascular Disease in CKD (CRIC) R01
Patrick H. Pun Nephrology Evaluating and Improving Cardiac Arrest Resuscitation Efforts in Hemodialysis Clinics R03
Rasheeda K. Hall Nephrology Improving Quality of Life Measurement in Older Dialysis Patients R03
Steven D. Crowley Nephrology Role of Th1 Immune Responses in the Pathogenesis of Hypertensive Kidney Injury R01
Steven D. Crowley Nephrology Role of Dendritic Cell-mediated T Cell Activation in Salt-sensitive Hypertension R01
Susan B. Gurley Nephrology Actions of Angiotensin II Along the Nephron to Regulate Blood Pressure R01
Thomas M. Coffman Nephrology Paracrine Control of Blood Pressure by Renal Intercalated Cells R01
Uptal Patel Nephrology Integrated Population Program for Diabetic Kidney Disease R34
Christopher Cox Pulmonary Improving decision making for patients with prolonged mechanical ventilation R01
Christopher Cox Pulmonary HABP/VABP R18
Claude A. Piantadosi Pulmonary

Mitochondrial quality control and alveolar damage resolution after acute lung injury 

R01
David M. Murdoch Pulmonary A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation R01
David M. Murdoch Pulmonary Magnetically directed single cell transcriptome analysis in HIV latency R01
Harvey Marshall Pulmonary S-nitrosothiols, NF-KappaB and Inflammation in Acute Lung Injury R01

Jennifer L. Ingram

Pulmonary

Mechanisms that Direct Airway Remodeling in Obese Asthma

R01

Loretta Que Pulmonary Modulation of Asthma by GSNO-based Therapies R01

Robert M. Tighe

Pulmonary

CXCL10/CXCR3 regulation of ozone-induced epithelial permeability

R01

Timothy J. McMahon

Pulmonary

Hand-held advanced functional imager for assessing local tissue oxygenation

R44
Donghai Wang Rheumatology and Immunology Censoring Inflammation by Protein Geranylgeranylation R01
Donghai Wang Rheumatology and Immunology Innate Immune Inhibition of the Mevalonate Pathway Impairs Neurodevelopment during ZIKV Infection R21

Virginia B. Kraus

Rheumatology and Immunology

Qualification of Prognostic and Diagnostic Biomarkers of Knee Osteoarthritis

R01

Virginia B. Kraus

Rheumatology and Immunology

Epigenetic Mechanisms Promoting Longevity

R56

Career Development

Investigator Division Project Grant
Ann M. Navar Boggan Cardiology Preventing Cardiovascular Disease through Improved Risk Prediction and Communication K01
Dennis M. Abraham Cardiology TREK-1 in fibroblast differentiation and cardiac fibrosis development K08

James W. Wisler

Cardiology

Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation

K08

Ravi Karra Cardiology Biomarkers of Heart Regeneration K08
Sudarshan Rajagopal Cardiology Noncanonical Receptor Signaling in Pulmonary Arterial Hypertension K08
Phuong L. Doan Cell Therapy

Role of ErbB receptor signaling in regulating normal and leukemic stem cell fate 

K08
Diego Bohorquez Gastroenterology Gut-Brain Neurocircuit Modulating Eating Behavior K01
Katherine Garman Gastroenterology Submucosal esophageal structures as a progenitor niche for esophageal repair K08
Clarissa J. Diamantidis General Internal Medicine Is there a digital divide in Chronic Kidney Disease (CKD)? K23
Nia Mitchell General Internal Medicine Evaluation of Low Cost National Weight Loss Program in Underserved K01
Cathleen S. Colon-Emeric Geriatrics Mentoring Intervention Development in Fall and Fracture Prevention K24
Grace M. Lee Hematology Biological Significance of Protamine/Heparin Antibodies K08
Marilyn J. Telen Hematology Duke-UNC Clinical Hematology and Transfusion Research Career Development Program K12
James White Hematology

The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells

K01
L. Gayani Tillekeratne Infectious Diseases Novel Diagnostics to Improve Antimicrobial Stewardship for Acute Respiratory Tract Infections in Resource-Limited Settings K23
Matthew P. Rubach Infectious Diseases Viral Zoonoses and Severe Febrile Illness in Northern Tanzania K23
Rebekah W. Moehring Infectious Diseases Defining Measures of Impact for Antimicrobial Stewardship Programs in Community Hospitals K08
Vance G. Fowler Jr. Infectious Diseases Mentoring Patient Oriented Research in Antibiotic-Resistant Bacteria K24
Arif H. Kamal Medical Oncology Which palliative care quality measures improve patient-centered outcomes? K08
Brent A. Hanks Medical Oncology Melanoma-mediated Dendritic Cell Tolerization and Immune Evasion K08

Gentzon Hall

Nephrology

The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS

K08

Myles S. Wolf Nephrology Mentored Patient-Oriented Research in Mineral Metabolism K24
Patrick H. Pun Nephrology Risk Factors for Sudden Cardiac Death in Patients with Chronic Kidney Disease K23
Bryan D. Kraft Pulmonary Role of S-nitrosothiols in Akt1 signaling and pneumonia resolution K08
Christina E. Barkauskas Pulmonary The role of Pdgfra+ fibroblasts in lung fibrosis and alveolar homeostasis K08
Jamie L. Todd Pulmonary Immune Profiles to Better Understand Chronic Allograft Dysfunction and Successful Long-term Clinical Outcomes after Human Lung Transplantation K23
Yen Rei Yu Pulmonary Role of Resident Monocytes in the Pathogenesis of Pulmonary Arterial Hypertension K08