Souma Lab


Tomokazu Souma, Primary Investigator

Tomokazu Souma, MD, PhD
Assistant Professor 
Division of Nephrology

Affiliate of the Regeneration Next Initiative

2 Genome Ct. Rm 2017
Durham NC 27710



Post-doctoral Fellowship, Feinberg Cardiovascular Research Institute, Northwestern University

Post-doctoral Fellowship, Department Of Medical Biochemistry, Tohoku University (Japan)

PhD, Tohoku University (Japan)

MD, Shimane University

Lab Members

Shintaro Ide, MD, PhD

Postdoctoral Fellow

Kana Ide, MD, PhD
Research Scientist

Anisha Watwe
Duke undergraduate student

Xuanyu Zhou
Duke undergraduate student

Former Lab Members

Sarah Strausser



The Souma lab in Duke Nephrology studies the basic mechanisms of kidney injuries and repair. We are particularly interested in elucidating molecular mechanisms of acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Our research primarily focuses on understanding cellular stress adaptive pathways such as KEAP1-NRF2 anti-oxidative stress pathway and HIF anti-hypoxia pathway in kidneys. Our ultimate goal is to harness these pathways for therapeutic uses to prevent kidney disease progression in patients. To better understand how renal epithelial cells adapt to oxidative and hypoxic stresses and how these pathways are impaired in disease conditions, the Souma lab utilizes cutting-edge mouse genetics, cell biological and single-cell approaches in the settings of kidney injuries.


In situ mRNA detection on injured kidney: