Souma Lab

MSRBII RM 1045

Tomokazu Souma, Primary Investigator

Tomokazu Souma, MD, PhD
Medical Instructor 
Division of Nephrology

Affiliate of the Regeneration Next Initiative

Office
2 Genome Ct. Rm 2017
Durham NC 27710

Email
tomokazu.souma@duke.edu

Education

Post-doctoral Fellowship, Feinberg Cardiovascular Research Institute, Northwestern University

Post-doctoral Fellowship, Department Of Medical Biochemistry, Tohoku University (Japan)

PhD, Tohoku University (Japan)

MD, Shimane University

Lab Members

 

Shintaro Ide

 

Postdoctoral Fellow

Sarah Strausser
Research Technician I

Anisha Watwe
Duke undergraduate student
 

Description

The Souma lab in Duke Nephrology studies the basic mechanisms of kidney injuries and repair. We are particularly interested in elucidating molecular mechanisms of acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Our research primarily focuses on understanding cellular stress adaptive pathways such as KEAP1-NRF2 anti-oxidative stress pathway and HIF anti-hypoxia pathway in kidneys. Our ultimate goal is to harness these pathways for therapeutic uses to prevent kidney disease progression in patients. To better understand how renal epithelial cells adapt to oxidative and hypoxic stresses and how these pathways are impaired in disease conditions, the Souma lab utilizes cutting-edge mouse genetics, cell biological and single-cell approaches in the settings of kidney injuries.

 

In situ mRNA detection on injured kidney: