Tomokazu Souma, Primary Investigator
Tomokazu Souma, MD, PhD
Medical Instructor
Division of Nephrology
Affiliate of the Regeneration Next Initiative
Office
2 Genome Ct. Rm 2017
Durham NC 27710
Education
Post-doctoral Fellowship, Feinberg Cardiovascular Research Institute, Northwestern University
Post-doctoral Fellowship, Department Of Medical Biochemistry, Tohoku University (Japan)
PhD, Tohoku University (Japan)
MD, Shimane University
Lab Members
Shintaro Ide
Postdoctoral Fellow
Sarah Strausser
Research Technician I
Anisha Watwe
Duke undergraduate student
Description
The Souma lab in Duke Nephrology studies the basic mechanisms of kidney injuries and repair. We are particularly interested in elucidating molecular mechanisms of acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Our research primarily focuses on understanding cellular stress adaptive pathways such as KEAP1-NRF2 anti-oxidative stress pathway and HIF anti-hypoxia pathway in kidneys. Our ultimate goal is to harness these pathways for therapeutic uses to prevent kidney disease progression in patients. To better understand how renal epithelial cells adapt to oxidative and hypoxic stresses and how these pathways are impaired in disease conditions, the Souma lab utilizes cutting-edge mouse genetics, cell biological and single-cell approaches in the settings of kidney injuries.
