Research Laboratories

Each of our divisions is home to research faculty exploring basic and translation science. Learn more about those faculty by browsing the divisions.

Many of our research labs also present additional information about their teams, projects, publications and opportunities for collaboration.

Arepally Lab

The Arepally Lab is currently has three studies on cellular basis of heparin-induced thrombocytopenia, protamine/heparin antibodies and biomarkers of arterial and venous thrombosis.

Basic Research Lab

The Diehl Basic Science Lab has identified liver gene expressions that differentiate patients with advanced NAFLD from those with milder versions. We have also discovered that many differences in liver gene expressions reflect epigenetic difference among individuals. These results combined may be used to modify epigenetic mechanisms to promote and optimize regeneration of the liver.

Coffman Lab

The Coffman Lab is interested in understanding the role of the kidney in disease states such as hypertension and chronic kidney disease. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases

Erythrocyte and SCD Biology

The Erythrocye and SCD Biology Lab focuses on the behavior and interactions of red cells and other blood cells in sickle cell disease, including especially the role of adhesion molecules on red cells and how their activity is regulated by the erythrocyte. The lab also explore the mechanisms whereby non-hemoglobin gene polymorphisms affect pathophysiology and clinical outcomes in sickle cell disease.

Garman Lab

The Garman laboratory focuses on injury, repair, and cancer development in the gastrointestinal tract. We perform translational research with the goal of improving health of the gastrointestinal tract.

Klotman Lab

The Klotman Lab is lead by Mary E. Klotman, MD, professor of medicine. The lab focuses on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Liddle Laboratory

The Liddle Laboratory has had a longstanding interest in two types of enteroendocrine cells (EECs) that regulate satiety and signal the brain to stop eating. Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain. Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety. 

Rajagopal Lab

The major interest of the Rajagopal lab is in understanding the phenomenon of biased agonism, especially as it relates to cardiovascular disease. Specifically, we are interested in signaling by GPCRs in pulmonary arterial hypertension (PAH), a rare disease of the pulmonary vasculature that leads to heart failure and death, and of the mechanisms underlying biased agonism in the chemokine family.

Souma Lab

The Souma lab studies the basic mechanisms of kidney injuries and repair. We are particularly interested in elucidating molecular mechanisms of acute kidney injury (AKI) to chronic kidney disease (CKD) transition.

Sparks Lab

The Sparks Lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure and diabetic nephropathy pathogenesis by altering blood flow to the kidney.

Spurney Lab

The Spurney Lab has focused on the role of G-protein coupled receptors (GPCRs) in regulating cellular physiology both in normal and disease states, as well as the regulatory mechanisms that modulate GPCR responsiveness at the molecular level.

Strouse Clinical Research Program in Sickle Cell Disease

The Strouse Clinical Research Program studies retrospective and prospective cohorts of children and adults with sickle cell disease to study stroke, silent cerebral infarct, and cognitive impairment. The lab is optimizing pseudo continuous arterial spin labeled MRI to measure cerebral blood flow as a potential predictor of risk of future stroke and silent cerebral infarct in adults with sickle cell disease and stroke. 

Wolf Lab

The Wolf Lab comprehensively investigates the role of FGF23 in normal mineral metabolism and in CKD, its adverse impact on cardiovascular disease (CVD), and the molecular mechanisms that underlie these effects.