Active NIH grants

Medicine faculty and trainees receive significant research and career-development support from the National Institutes of Health. The tables below list faculty with current grants from R and K mechanisms.

These tables were last updated April 2021.

Research Programs

Investigator Division Project Grant
Michael Dee Gunn Cardiology Generation of antibodies specific for optimal non-HRP2 malaria diagnostic antigens R21

Christopher Holley

Cardiology

The Role of RNA Modifications in Heart Failure

R01

Christopher Holley

Cardiology SnoRNA-guided modifications of mRNA R01
Robert J. Lefkowitz Cardiology Molecular Regulation of Cardiovascular 7 TM Receptors R01
Yongmei Liu Cardiology Obesity-Related Epigenetic Changes and Type-2 Diabetes​ R01

Yongmei Liu

Cardiology A Longitudinal Epigenetic Study of Atherosclerosis R01
Manesh R. Patel Cardiology BEST-VIVA Registry (vCLI) R01

Sudarshan Rajagopal

Cardiology

Biasing CXCR3 Signaling to Modulate the Inflammatory Response

R01
Howard Rockman Cardiology Mechanisms of Maladaptation in Heart Failure R01
Svati H. Shah Cardiology Clinical and Molecular Epidemiology of High Risk Coronary Plaque R01
Sudha Shenoy Cardiology Regulation of Vascular Inflammatory Signaling by the Deubiquitinase USP20 R01
Jonathan A. Stiber Cardiology Anti-Atherogenic Mechanisms of Drebrin R01
S. Munir Alam Duke Human Vaccine Institute Antigen recognition and activation of B-cell receptors of HIV-1 broadly neutralizing antibodies R01
Mattia Bonsignori Duke Human Vaccine Institute Immunogen Design Strategies To Direct Hiv-1 Broadly Neutralizing Antibody Maturation By Probability-Based Targeting Of Critical Mutations R56
Wilton B. Williams Duke Human Vaccine Institute Neonatal Immunity to novel TF SHIVs R01
Jonathan Campbell Endocrinology, Metabolism, and Nutrition Mechanisms of insulin secretion mediated by alpha cells R01
Jonathan Campbell Endocrinology, Metabolism, and Nutrition Novel metabolic actions of GIP R01
David D'Alessio Endocrinology, Metabolism, and Nutrition Incretion Action in Physiology and Diabetes  R01
Mark Herman Endocrinology, Metabolism, and Nutrition The Role of ChREBP in Fructose Induced Metabolic Disease R01
Matthew D. Hirschey Endocrinology, Metabolism, and Nutrition Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism R01
Matthew D. Hirschey Endocrinology, Metabolism, and Nutrition Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease R01
Matthew D. Hirschey Endocrinology, Metabolism, and Nutrition Determining the Sub-Cellular Organelles that Link Lipid Signaling and Epigenetics R21
Deborah Muoio Endocrinology, Metabolism, and Nutrition Mechanisms of lipid-induced bioenergetic stress in muscle R01
Diego Bohorquez Gastroenterology The efferent synapse in enteroendocrine cells R21
Anna Mae Diehl Gastroenterology TNF Alpha and Recovery from Alcoholic Liver Injury R01
Anna Mae Diehl Gastroenterology Hedgehog Signaling and Adult Liver Regeneration R01
Katherine Garman Gastroenterology The role of gastrin in esophageal submucosal gland acinar ductal metaplasia R01
Rodger A. Liddle Gastroenterology Mechanisms of mechanically-induced acute pancreatitis R01
Rodger A. Liddle Gastroenterology The role of gut endocrine cells in Parkinson's Disease R01
Rodger A. Liddle Gastroenterology Mechanisms of Pancreatic Fibrosis R01
Rodger A. Liddle Gastroenterology Metabolic regulation of pancreatitis R01
Jatin Roper Gastroenterology Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy R21

Keisha Bentley-Edwards

General Internal Medicine

Religion, Spirituality and CVD Risks: A Focus on African Americans

R01

L. Ebony Boulware General Internal Medicine Health system outreach to eliminate disparities in living kidney transplants R01
Susanne B. Haga General Internal Medicine Preparing Genetic Counselors for Genomic Medicine Research R25
Nia S. Mitchell General Internal Medicine

Changes in Weight and Physical Function for Older African American Women in National, Peer-Led, Community-Based Weight Loss Program

R01
Christopher B. Bowling  Geriatrics

Functional Limitations and Disability Among Middle-Aged Adults

R01
Christopher B. Bowling  Geriatrics Sustained blood pressure control and progression of multimorbidity R01
Daniel Parker Geriatrics Healthy Skeletal Muscle, Healthy Brain: Are Kynurenine Metabolics the Link? R03
Patrick M. Sullivan Geriatrics A Novel Animal Model of Late Onset Alzheimer's Disease R21
Gregory A. Taylor Geriatrics Role of IRGM proteins in immunity to enteric bacteria R01

Gregory A. Taylor

Geriatrics IRGM proteins as regulators of inflammation R01
Nelson J. Chao Hematologic Malignancies and Cellular Therapy Patient-centered home-based hematopoietic stem cell transplantation R01
Yubin Kang Hematologic Malignancies and Cellular Therapy Targeting sphingosine kinase 2 for the treatment of multiple myeloma R01
Yubin Kang Hematologic Malignancies and Cellular Therapy Effects of PPAR agonists on response to immunomodulatory agents in patients with multiple myeloma R21
Stefanie Sarantopoulos Hematologic Malignancies and Cellular Therapy Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD R01
Dorothy Sipkins Hematologic Malignancies and Cellular Therapy Defining the Rules of Breast Cancer Cell Traffic Through Bone R01
Dorothy Sipkins Hematologic Malignancies and Cellular Therapy Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis R01
Anthony D. Sung Hematologic Malignancies and Cellular Therapy Home-based Autologous Hematopoietic Stem Cell Transplantation to Improve Outcomes and Decrease Cost R01
Anthony D. Sung Hematologic Malignancies and Cellular Therapy Prebiotics to Optimize the Microbiota and Improve Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation R01
Anthony D. Sung Hematologic Malignancies and Cellular Therapy Hematopoietic Stem Cell Transplantation Combined with CSF1 Inhibition to Attenuate the Pathogenesis of Alzheimer's Disease R03
Anthony D. Sung Hematologic Malignancies and Cellular Therapy

Evaluating Effects of Age-related Microbiota Modulations in Hematopoietic Stem Cell Transplant Patients

R21
Gowthami Arepally Hematology Complement and CR2/CD21 in the Immune Pathogenesis of HIT R01
Gowthami Arepally Hematology Complement and Thrombosis in HIT R01
J. Brice Weinberg Hematology Nitric Oxide and Microvascular Dysfunction in Severe Malaria R01
Rahima Zennadi Hematology Role of RBC Reactive Oxygen Species and Their Vicious Cycle in Sickle Vasculopahty R01
Grace M. Lee Hematology Variability in neutrophil activation R03
Grace M. Lee Hematology Neutrophil Activation Phenotypes in Healthy Subjects and Implications for Bacterial Clearance R21
James White Hematology Assessing healthspan and epigenetics in aged mice after prolonged exposure to young circulation R21
Andrew Alspaugh Infectious Diseases Coordinated Regulation of Virulence Genes in C. neoformans R01
Andrew Alspaugh Infectious Diseases

Metal Homeostasis in Yeast

R01
Maria Blasi Infectious Diseases Targeting the HIV-1 reservoir with a combination of an IDLV-SIVGag therapeutic vaccine and Fc-engineered bnAbs R56
Vivian H. Chu Infectious Diseases Bridging the Gap to Enhance Clinical Research Program (BIGGER) R25
Feng Gao Infectious Diseases Dissection of polyreactivity and neutralization activity of HIV-1 Abs R01
Greg Gray Infectious Diseases Swine Influenza Virus Transmission in Confined Animal Feeding Operations, China R01
Mary E. Klotman Chair's Office

The Genitourinary Tract as a compartment and reservoir for HIV

R01
Thuy Le Infectious Diseases Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast Asia R01
Susanna Naggie Infectious Diseases Identification of Novel Bioactive Lipid Metabolites for Predicting Liver-related Outcomes in Persons Co-Infected with HIV and HCV R01
John Perfect Infectious Diseases Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDS R01
Wendy A. Prudhomme - O'Meara Infectious Diseases Malaria diagnostic testing and conditional subsidies to target ACTs in the retail sector: the TESTsmART trial R01

Wendy A. Prudhomme - O'Meara

Infectious Diseases Once bitten: A longitudinal, observational study of successful malaria parasite transmission events between humans and mosquitos R01
Matthew P. Rubach Infectious Diseases Sepsis Characterization in Kilimanjaro R01
Steve Taylor Infectious Diseases Malaria chemoprevention in children with sickle cell anemia in Western Kenya R01
Steve Taylor Infectious Diseases Estimating the incremental benefits on active malaria case detection of high-sensitivity rapid diagnostic tests R03
Andrew Armstrong Medical Oncology Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer R01
Gerard C. Blobe Medical Oncology Role of ALK4 in Regulating Receptor Trafficking and Pancreatic Cancer Biology R01
Gerard C. Blobe Medical Oncology Role for TbetaRIII Shedding in the Tumor Microenvironment R01
Jennifer A. Freedman Medical Oncology Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer R01
Brent A. Hanks Medical Oncology Investigating the PD-L1:NLRP3 signaling axis as a tumor intrinsic mechanism of adaptive resistance to anti-PD-1 antibody immunotherapy R37
Kevin C. Oeffinger Medical Oncology Onco-primary care networking to support TEAM-based care - the ONE TEAM Study R01

Steven Patierno

Medical Oncology

Race-related alternative splicing: novel targets in prostate cancer

R01
Steven D. Crowley Nephrology The interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertension R01
Mary H. Foster Nephrology Gene-Environment Collaboration in Autoimmune Disease R01
Xunrong Luo Nephrology Modeling concurrent cytomegalovirus infection and transplantation tolerance R01
Tomokazu Souma Nephrology Targeting Renal Tubular Epithelial Progenitors in AKI to CKD transition R01
Christina M. Wyatt Nephrology Impact of early antiretroviral therapy on kidney disease outcomes R01
Jennifer L. Ingram Pulmonary, Allergy, and Critical Care Medicine Mechanisms that Direct Airway Remodeling in Obese Asthma R01
Jennifer L. Ingram Pulmonary, Allergy, and Critical Care Medicine

Matrix Metalloproteinase-19 as a Mediator of Airway Fibrosis in Obese Allergic Asthma

R21
Patty Lee Pulmonary, Allergy and Critical Care Medicine

TLR4-mediated Epigenetic and Senescence Mechanisms in Emphysema

R01
David M. Murdoch Pulmonary, Allergy, and Critical Care Medicine Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users R01
David M. Murdoch Pulmonary, Allergy, and Critical Care Medicine Magnetically directed single cell transcriptome analysis in HIV latency R01
David M. Murdoch Pulmonary, Allergy, and Critical Care Medicine A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation R01
Scott M. Palmer Pulmonary, Allergy and Critical Care Medicine

Proof of concept treatment interventions in a rodent model of the rare disease bronchiolitis obliterans

R21
Claude A. Piantadosi Pulmonary, Allergy, and Critical Care Medicine

Mitochondrial quality control and alveolar damage resolution after acute lung injury 

R01
Loretta Que Pulmonary, Allergy and Critical Care Medicine

Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma

R01

Robert M. Tighe

Pulmonary, Allergy, and Critical Care Medicine

CXCL10/CXCR3 regulation of ozone-induced epithelial permeability

R01
Brian Andonian Rheumatology and Immunology

Accelerated Metabolic Aging in Rheumatoid Arthritis Immune cells and Skeletal Muscle: A Pilot Study

R03
Kim M. Huffman Rheumatology and Immunology

Weight loss and exercise to improve rheumatoid arthritis cardiovascular risk

R21
Kim M. Huffman Rheumatology and Immunology

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

R33
Virginia B. Kraus Rheumatology and Immunology

Epigenetic Mechanisms Promoting Longevity

R01
Virginia B. Kraus Rheumatology and Immunology Extracellular Vesicles and Their Role in Hallmarks of Aging R01

Career Development

Investigator Division Project Grant
Marat Fudim Cardiology Congestion Phenotypes and Splanchnic Nerve Modulation in Chronic Heart Failure K23
Robert W. McGarrah III Cardiology The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section K08

James W. Wisler

Cardiology

Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation

K08

Monique L. Starks Cardiology Evaulation of the Requirements and Critical Features of a Drone-Deployed AED Network to Improve Community-Level Survival after OHCA K23
Richard H. Lee Endocrinology, Metabolism, and Nutrition Metabolomic & Radiographic Markers of Fracture Risk Among Older Adults with Diabetes​ K23
Nrupen Bhavsar General Internal Medicine Addressing Bias from Missing Data in EHR Based Studies of CVD K01
Cathleen S. Colon-Emeric Geriatrics Mentoring Intervention Development in Fall and Fracture Prevention​ K24
Juliessa Pavon Geriatrics

Deprescribing Central Nervous System Medications in Hospitalized Older Adults

K23
James White Hematology The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells K01
Vance G. Fowler Jr. Infectious Diseases Mentoring Patient Oriented Research in Antibiotic-Resistant Bacteria​ K24
Nwora L. Okeke Infectious Diseases A Clinic-Based Behavioral Intervention to Reduce Cardiovascular Disease Risk in Persons Living with HIV​ K23
Matthew P. Rubach Infectious Diseases Viral Zoonoses and Severe Febrile Illness in Northern Tanzania K23
L. Gayani Tillekeratne Infectious Diseases Novel Diagnostics to Improve Antimicrobial Stewardship for Acute Respiratory Tract Infections in Resource-Limited Settings K23

Gentzon Hall

Nephrology

The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS

K08

Rasheeda K. Hall Nephrology Deprescribing for Older Dialysis Patients K76
Laura P. Svetkey Nephrology Duke CTSA (KL2) KL2
Crystal C. Tyson Nephrology Diet and Hypertension Management in Chronic Kidney Disease K01
Brian D. Kraft Pulmonary, Allergy, and Critical Care Medicine

Role of S-nitrosothiols in Akt1 signaling and pneumonia resolution

K08
Yen Rei Yu Pulmonary, Allergy, and Critical Care Medicine Role of Resident Monocytes in the Pathogenesis of Pulmonary Arterial Hypertension K08
Jamie L. Todd Pulmonary, Allergy, and Critical Care Medicine Immune Profiles to Better Understand Chronic Allograft Dysfunction and Successful Long-term Clinical Outcomes after Human Lung Transplantation K23
Zachary R. Healy Pulmonary, Allergy, and Critical Care Medicine Characterization of CMV-specific T cell responses in immunocompromised hosts K99