Education and Training
- Ph.D., University of Connecticut, 2008
Liu, X, Ahn, S, Kahsai, AW, Meng, K-C, Latorraca, NR, Pani, B, Venkatakrishnan, AJ, Masoudi, A, Weis, WI, Dror, RO, Chen, X, Lefkowitz, RJ, and Kobilka, BK. "Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure." Nature 548, no. 7668 (August 16, 2017): 480-484.
Dong, J-H, Wang, Y-J, Cui, M, Wang, X-J, Zheng, W-S, Ma, M-L, Yang, F, He, D-F, Hu, Q-X, Zhang, D-L, Ning, S-L, Liu, C-H, Wang, C, Wang, Y, Li, X-Y, Yi, F, Lin, A, Kahsai, AW, Cahill, TJ, Chen, Z-Y, Yu, X, and Sun, J-P. "Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism." Biological psychiatry 81, no. 8 (April 2017): 654-670.
Cahill, TJ, Thomsen, ARB, Tarrasch, JT, Plouffe, B, Nguyen, AH, Yang, F, Huang, L-Y, Kahsai, AW, Bassoni, DL, Gavino, BJ, Lamerdin, JE, Triest, S, Shukla, AK, Berger, B, Little, J, Antar, A, Blanc, A, Qu, C-X, Chen, X, Kawakami, K, Inoue, A, Aoki, J, Steyaert, J, Sun, J-P, Bouvier, M, Skiniotis, G, and Lefkowitz, RJ. "Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis." Proceedings of the National Academy of Sciences of the United States of America 114, no. 10 (March 2017): 2562-2567.
Liu, C-H, Gong, Z, Liang, Z-L, Liu, Z-X, Yang, F, Sun, Y-J, Ma, M-L, Wang, Y-J, Ji, C-R, Wang, Y-H, Wang, M-J, Cui, F-A, Lin, A, Zheng, W-S, He, D-F, Qu, C-X, Xiao, P, Liu, C-Y, Thomsen, ARB, Joseph Cahill, T, Kahsai, AW, Yi, F, Xiao, K-H, Xue, T, Zhou, Z, Yu, X, and Sun, J-P. "Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling." Nature communications 8 (February 9, 2017): 14335-.
Ahn, S, Kahsai, AW, Pani, B, Wang, Q-T, Zhao, S, Wall, AL, Strachan, RT, Staus, DP, Wingler, LM, Sun, LD, Sinnaeve, J, Choi, M, Cho, T, Xu, TT, Hansen, GM, Burnett, MB, Lamerdin, JE, Bassoni, DL, Gavino, BJ, Husemoen, G, Olsen, EK, Franch, T, Costanzi, S, Chen, X, and Lefkowitz, RJ. "Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library." Proceedings of the National Academy of Sciences of the United States of America 114, no. 7 (February 2017): 1708-1713.
Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, ARB, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. "Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor." Nature chemical biology 12, no. 9 (September 2016): 709-716.
Thomsen, ARB, Plouffe, B, Cahill, TJ, Shukla, AK, Tarrasch, JT, Dosey, AM, Kahsai, AW, Strachan, RT, Pani, B, Mahoney, JP, Huang, L, Breton, B, Heydenreich, FM, Sunahara, RK, Skiniotis, G, Bouvier, M, and Lefkowitz, RJ. "GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling." Cell 166, no. 4 (August 3, 2016): 907-919.
Staus, DP, Strachan, RT, Manglik, A, Pani, B, Kahsai, AW, Kim, TH, Wingler, LM, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, AC, Pardon, E, Steyaert, J, Weis, WI, Prosser, RS, Kobilka, BK, Costa, T, and Lefkowitz, RJ. "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation." Nature 535, no. 7612 (July 13, 2016): 448-452.
Shukla, AK, Westfield, GH, Xiao, K, Reis, RI, Huang, L-Y, Tripathi-Shukla, P, Qian, J, Li, S, Blanc, A, Oleskie, AN, Dosey, AM, Su, M, Liang, C-R, Gu, L-L, Shan, J-M, Chen, X, Hanna, R, Choi, M, Yao, XJ, Klink, BU, Kahsai, AW, Sidhu, SS, Koide, S, Penczek, PA, Kossiakoff, AA, Woods, VL, Kobilka, BK, Skiniotis, G, and Lefkowitz, RJ. "Visualization of arrestin recruitment by a G-protein-coupled receptor." Nature 512, no. 7513 (August 2014): 218-222.
Kahsai, AW, Rajagopal, S, Sun, J, and Xiao, K. "Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry." Nature protocols 9, no. 6 (January 2014): 1301-1319.