Alem W Kahsai, PhD

Publications

Liu, Xiangyu, Ali Masoudi, Alem W. Kahsai, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, et al. “Mechanism of β2AR regulation by an intracellular positive allosteric modulator..” Science 364, no. 6447 (June 28, 2019): 1283–87. https://doi.org/10.1126/science.aaw8981.

PMID
31249059
Full Text

Ahn, Seungkirl, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestergaard, Lei Jin, et al. “Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries..” Mol Pharmacol 94, no. 2 (August 2018): 850–61. https://doi.org/10.1124/mol.118.111948.

PMID
29769246
Full Text

Meng, Kaicheng, Paul Shim, Qingtin Wang, Shuai Zhao, Ting Gu, Alem W. Kahsai, Seungkirl Ahn, and Xin Chen. “Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor..” Bioorg Med Chem 26, no. 9 (May 15, 2018): 2320–30. https://doi.org/10.1016/j.bmc.2018.03.023.

PMID
29588128
Full Text

Zhang, Dao-Lai, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, et al. “Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility..” Elife 7 (February 2, 2018). https://doi.org/10.7554/eLife.33432.

PMID
29393851
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Liu, Xiangyu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, et al. “Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure..” Nature 548, no. 7668 (August 16, 2017): 480–84. https://doi.org/10.1038/nature23652.

PMID
28813418
Full Text

Dong, Jun-Hong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, et al. “Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism..” Biol Psychiatry 81, no. 8 (April 15, 2017): 654–70. https://doi.org/10.1016/j.biopsych.2016.09.025.

PMID
27916196
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Cahill, Thomas J., Alex R. B. Thomsen, Jeffrey T. Tarrasch, Bianca Plouffe, Anthony H. Nguyen, Fan Yang, Li-Yin Huang, et al. “Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis..” Proc Natl Acad Sci U S A 114, no. 10 (March 7, 2017): 2562–67. https://doi.org/10.1073/pnas.1701529114.

PMID
28223524
Full Text

Ahn, Seungkirl, Alem W. Kahsai, Biswaranjan Pani, Qin-Ting Wang, Shuai Zhao, Alissa L. Wall, Ryan T. Strachan, et al. “Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library..” Proc Natl Acad Sci U S A 114, no. 7 (February 14, 2017): 1708–13. https://doi.org/10.1073/pnas.1620645114.

PMID
28130548
Full Text

Liu, Chun-Hua, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, et al. “Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling..” Nat Commun 8 (February 9, 2017). https://doi.org/10.1038/ncomms14335.

PMID
28181498
Full Text

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