Alem W Kahsai, PhD

Assistant Professor in Medicine
Email address ak159@duke.edu

Education and Training

  • Ph.D., University of Connecticut, 2008

Publications

Ahn, S, Pani, B, Kahsai, AW, Olsen, EK, Husemoen, G, Vestergaard, M, Jin, L, Zhao, S, Wingler, LM, Rambarat, PK, Simhal, RK, Xu, TT, Sun, LD, Shim, PJ, Staus, DP, Huang, L-Y, Franch, T, Chen, X, and Lefkowitz, RJ. "Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries." Molecular Pharmacology 94, no. 2 (August 2018): 850-861.

PMID
29769246
Full Text

Kahsai, AW, Pani, B, and Lefkowitz, RJ. "GPCR signaling: conformational activation of arrestins." Cell Research 28, no. 8 (August 2018): 783-784.

PMID
30030517
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Meng, K, Shim, P, Wang, Q, Zhao, S, Gu, T, Kahsai, AW, Ahn, S, and Chen, X. "Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor." Bioorganic & Medicinal Chemistry 26, no. 9 (May 2018): 2320-2330.

PMID
29588128
Full Text

Zhang, D-L, Sun, Y-J, Ma, M-L, Wang, Y-J, Lin, H, Li, R-R, Liang, Z-L, Gao, Y, Yang, Z, He, D-F, Lin, A, Mo, H, Lu, Y-J, Li, M-J, Kong, W, Chung, KY, Yi, F, Li, J-Y, Qin, Y-Y, Li, J, Thomsen, ARB, Kahsai, AW, Chen, Z-J, Xu, Z-G, Liu, M, Li, D, Yu, X, and Sun, J-P. "Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility." eLife 7 (February 2, 2018).

PMID
29393851
Full Text

Liu, X, Ahn, S, Kahsai, AW, Meng, K-C, Latorraca, NR, Pani, B, Venkatakrishnan, AJ, Masoudi, A, Weis, WI, Dror, RO, Chen, X, Lefkowitz, RJ, and Kobilka, BK. "Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure." Nature 548, no. 7668 (August 16, 2017): 480-484.

PMID
28813418
Full Text

Dong, J-H, Wang, Y-J, Cui, M, Wang, X-J, Zheng, W-S, Ma, M-L, Yang, F, He, D-F, Hu, Q-X, Zhang, D-L, Ning, S-L, Liu, C-H, Wang, C, Wang, Y, Li, X-Y, Yi, F, Lin, A, Kahsai, AW, Cahill, TJ, Chen, Z-Y, Yu, X, and Sun, J-P. "Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism." Biological Psychiatry 81, no. 8 (April 2017): 654-670.

PMID
27916196
Full Text

Cahill, TJ, Thomsen, ARB, Tarrasch, JT, Plouffe, B, Nguyen, AH, Yang, F, Huang, L-Y, Kahsai, AW, Bassoni, DL, Gavino, BJ, Lamerdin, JE, Triest, S, Shukla, AK, Berger, B, Little, J, Antar, A, Blanc, A, Qu, C-X, Chen, X, Kawakami, K, Inoue, A, Aoki, J, Steyaert, J, Sun, J-P, Bouvier, M, Skiniotis, G, and Lefkowitz, RJ. "Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis." Proceedings of the National Academy of Sciences of the United States of America 114, no. 10 (March 2017): 2562-2567.

PMID
28223524
Full Text

Liu, C-H, Gong, Z, Liang, Z-L, Liu, Z-X, Yang, F, Sun, Y-J, Ma, M-L, Wang, Y-J, Ji, C-R, Wang, Y-H, Wang, M-J, Cui, F-A, Lin, A, Zheng, W-S, He, D-F, Qu, C-X, Xiao, P, Liu, C-Y, Thomsen, ARB, Joseph Cahill, T, Kahsai, AW, Yi, F, Xiao, K-H, Xue, T, Zhou, Z, Yu, X, and Sun, J-P. "Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling." Nature Communications 8 (February 9, 2017): 14335-null.

PMID
28181498
Full Text

Ahn, S, Kahsai, AW, Pani, B, Wang, Q-T, Zhao, S, Wall, AL, Strachan, RT, Staus, DP, Wingler, LM, Sun, LD, Sinnaeve, J, Choi, M, Cho, T, Xu, TT, Hansen, GM, Burnett, MB, Lamerdin, JE, Bassoni, DL, Gavino, BJ, Husemoen, G, Olsen, EK, Franch, T, Costanzi, S, Chen, X, and Lefkowitz, RJ. "Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library." Proceedings of the National Academy of Sciences of the United States of America 114, no. 7 (February 2017): 1708-1713.

PMID
28130548
Full Text

Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, ARB, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. "Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor." Nature chemical biology 12, no. 9 (September 2016): 709-716.

PMID
27398998
Full Text

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