Andrew John Armstrong, MD

Professor of Medicine
Associate Professor in Pharmacology and Cancer Biology
Professor in Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 103861, Durham, NC 27710
Phone (919) 668-8797
Email address

1. Predictors of sensitivity and clinical efficacy of therapies in advanced prostate cancer
2. Novel designs of clinical trials and pharmacodynamic/translational studies in prostate, kidney, bladder cancer
3. Pre-operative models for drug development of novel agents in human testing in prostate cancer
4. Novel therapies and drug development for prostate, renal, bladder, and testicular cancer
5. Design of rational combination therapies in men with metastatic hormone-refractory prostate cancer
6. PI3 kinase/mTOR inhibition in prostate cancer: mechanisms of sensitivity and resistance
7. Developing prognostic models for progression and survival in metastatic prostate cancer
8. Examining surrogate markers of mortality in metastatic prostate cancer
9. Clear cell and non-clear cell renal cell carcinoma: natural history, sensitivity to novel agents including mTOR and VEGF inhibition

In Their Words

Education and Training

  • Fellowship, Division Of Oncology/Hematology, Johns Hopkins University School of Medicine, 2003 - 2006
  • Internship/Residency, General Internal Medicine, University of Pennsylvania School of Medicine, 2000 - 2003
  • M.Sc., Johns Hopkins University, 2008
  • M.D., University of Virginia School of Medicine, 2000
  • B.S.E., Duke University, 1996



Armstrong, Andrew J., Russell Z. Szmulewitz, Daniel P. Petrylak, Jeffrey Holzbeierlein, Arnauld Villers, Arun Azad, Antonio Alcaraz, et al. “ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer..” J Clin Oncol 37, no. 32 (November 10, 2019): 2974–86.

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Yuan, Fuwen, William Hankey, Dayong Wu, Hongyan Wang, Jason Somarelli, Andrew J. Armstrong, Jiaoti Huang, Zhong Chen, and Qianben Wang. “Molecular determinants for enzalutamide-induced transcription in prostate cancer..” Nucleic Acids Res 47, no. 19 (November 4, 2019): 10104–14.

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Zhu, Jason, Matthew Tucker, Daniele Marin, Rajan T. Gupta, Patrick Healy, Michael Humeniuk, Casey Jarvis, et al. “Clinical utility of FoundationOne tissue molecular profiling in men with metastatic prostate cancer..” Urol Oncol 37, no. 11 (November 2019): 813.e1-813.e9.

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George, Daniel J., Susan Halabi, Patrick Healy, Ian Barak, Carolyn Winters, Monika Anand, Rhonda Wilder, et al. “Phase 1b trial of docetaxel, prednisone, and pazopanib in men with metastatic castration-resistant prostate cancer..” Prostate 79, no. 15 (November 2019): 1752–61.

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George, Daniel J., Susan Halabi, Patrick Healy, Darius Jonasch, Monika Anand, Julia Rasmussen, Sarah Y. Wood, Charles Spritzer, John F. Madden, and Andrew J. Armstrong. “Phase 2 clinical trial of TORC1 inhibition with everolimus in men with metastatic castration-resistant prostate cancer..” Urol Oncol, September 12, 2019.

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Higano, Celestia S., Andrew J. Armstrong, A Oliver Sartor, Nicholas J. Vogelzang, Philip W. Kantoff, David G. McLeod, Christopher M. Pieczonka, et al. “Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer..” Cancer, September 4, 2019.

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Freedland, Stephen J., Lauren Howard, Jenifer Allen, Jordan Smith, Jennifer Stout, William Aronson, Brant A. Inman, et al. “A lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trial..” Prostate Cancer Prostatic Dis 22, no. 3 (September 2019): 428–37.

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Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Howard I. Scher, Emmanuel S. Antonarakis, and Daniel J. George. “Reply to L. Dirix, B. De Laere et al, and A. Sharp et al..” J Clin Oncol 37, no. 24 (August 20, 2019): 2184–86.

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Tucker, Matthew D., Jason Zhu, Daniele Marin, Rajan T. Gupta, Santosh Gupta, William R. Berry, Sundhar Ramalingam, et al. “Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer..” Cancer Med 8, no. 10 (August 2019): 4644–55.

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Horvath, Lisa, Andrew J. Armstrong, Russell Szmulewitz, Daniel Petrylak, Arnauld Villers, Arun Azad, Antonio Alcaraz, et al. “Phase 3 Study of Androgen Deprivation Therapy (ADT) with Enzalutamide (ENZA) or Placebo (PBO) in Metastatic Hormone-Sensitive Prostate Cancer (MHSPC): The Arches Trial.” In Asia Pacific Journal of Clinical Oncology, 15:32–33. WILEY, 2019.