Andrew John Armstrong, MD

Professor of Medicine
Associate Professor in Pharmacology and Cancer Biology
Associate Professor in Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 103861, Durham, NC 27710
Phone (919) 668-8797
Email address

1. Predictors of sensitivity and clinical efficacy of therapies in advanced prostate cancer
2. Novel designs of clinical trials and pharmacodynamic/translational studies in prostate, kidney, bladder cancer
3. Pre-operative models for drug development of novel agents in human testing in prostate cancer
4. Novel therapies and drug development for prostate, renal, bladder, and testicular cancer
5. Design of rational combination therapies in men with metastatic hormone-refractory prostate cancer
6. PI3 kinase/mTOR inhibition in prostate cancer: mechanisms of sensitivity and resistance
7. Developing prognostic models for progression and survival in metastatic prostate cancer
8. Examining surrogate markers of mortality in metastatic prostate cancer
9. Clear cell and non-clear cell renal cell carcinoma: natural history, sensitivity to novel agents including mTOR and VEGF inhibition

In Their Words

Education and Training

  • Fellowship, Division Of Oncology/Hematology, Johns Hopkins University School of Medicine, 2003 - 2006
  • Internship/Residency, General Internal Medicine, University of Pennsylvania School of Medicine, 2000 - 2003
  • M.Sc., Johns Hopkins University, 2008
  • M.D., University of Virginia School of Medicine, 2000
  • B.S.E., Duke University, 1996



Armstrong, AJ. "Updates in advanced prostate cancer 2018." Prostate Cancer and Prostatic Diseases (October 2, 2018).

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Jolly, MK, Somarelli, JA, Sheth, M, Biddle, A, Tripathi, SC, Armstrong, AJ, Hanash, SM, Bapat, SA, Rangarajan, A, and Levine, H. "Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas." Pharmacology & Therapeutics (September 28, 2018). (Review)

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Beltran, H, Oromendia, C, Danila, DC, Montgomery, B, Hoimes, C, Szmulewitz, RZ, Vaishampayan, U, Armstrong, AJ, Stein, M, Pinski, J, Mosquera, JM, Sailer, V, Bareja, R, Romanel, A, Gumpeni, N, Sboner, A, Dardenne, E, Puca, L, Prandi, D, Rubin, MA, Scher, HI, Rickman, DS, Demichelis, F, Nanus, DM, Ballman, KV, and Tagawa, ST. "A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research (September 19, 2018).

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Zhang, T, George, DJ, and Armstrong, AJ. "Precision medicine approaches when prostate cancer Akts up." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research (September 11, 2018).

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Armstrong, AJ, Lin, P, Higano, CS, Sternberg, CN, Sonpavde, G, Tombal, B, Templeton, AJ, Fizazi, K, Phung, D, Wong, EK, Krivoshik, A, and Beer, TM. "Development and validation of a prognostic model for overall survival in chemotherapy-naïve men with metastatic castration-resistant prostate cancer." Annals of Oncology : Official Journal of the European Society for Medical Oncology (September 10, 2018).

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McNamara, M, Sweeney, C, Antonarakis, ES, and Armstrong, AJ. "The evolving landscape of metastatic hormone-sensitive prostate cancer: a critical review of the evidence for adding docetaxel or abiraterone to androgen deprivation." Prostate Cancer and Prostatic Diseases 21, no. 3 (September 2018): 306-318. (Review)

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Brown, LC, Sonpavde, G, and Armstrong, AJ. "Can RECIST response predict success in phase 3 trials in men with metastatic castration-resistant prostate cancer?." Prostate Cancer and Prostatic Diseases 21, no. 3 (September 2018): 419-430.

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Wu, M, Huang, P-H, Zhang, R, Mao, Z, Chen, C, Kemeny, G, Li, P, Lee, AV, Gyanchandani, R, Armstrong, AJ, Dao, M, Suresh, S, and Huang, TJ. "Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation." Small (Weinheim an Der Bergstrasse, Germany) 14, no. 32 (August 2018): e1801131-null.

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Armstrong, AJ, Anand, A, Edenbrandt, L, Bondesson, E, Bjartell, A, Widmark, A, Sternberg, CN, Pili, R, Tuvesson, H, Nordle, Ö, Carducci, MA, and Morris, MJ. "Phase 3 Assessment of the Automated Bone Scan Index as a Prognostic Imaging Biomarker of Overall Survival in Men With Metastatic Castration-Resistant Prostate Cancer: A Secondary Analysis of a Randomized Clinical Trial." Jama Oncology 4, no. 7 (July 2018): 944-951.

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Fantony, JJ, Howard, LE, Csizmadi, I, Armstrong, AJ, Lark, AL, Galet, C, Aronson, WJ, and Freedland, SJ. "Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study." Biomarkers in Medicine 12, no. 7 (July 2018): 727-736.

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