Andrew John Armstrong, MD

Associate Professor of Medicine
Associate Professor in Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 103861, Durham, NC 27710
Phone (919) 668-8797
Email address

1. Predictors of sensitivity and clinical efficacy of therapies in advanced prostate cancer
2. Novel designs of clinical trials and pharmacodynamic/translational studies in prostate, kidney, bladder cancer
3. Pre-operative models for drug development of novel agents in human testing in prostate cancer
4. Novel therapies and drug development for prostate, renal, bladder, and testicular cancer
5. Design of rational combination therapies in men with metastatic hormone-refractory prostate cancer
6. PI3 kinase/mTOR inhibition in prostate cancer: mechanisms of sensitivity and resistance
7. Developing prognostic models for progression and survival in metastatic prostate cancer
8. Examining surrogate markers of mortality in metastatic prostate cancer
9. Clear cell and non-clear cell renal cell carcinoma: natural history, sensitivity to novel agents including mTOR and VEGF inhibition

Education and Training

  • Fellowship, Division Of Oncology/Hematology, Johns Hopkins University School of Medicine, 2003 - 2006
  • Internship/Residency, General Internal Medicine, University of Pennsylvania School of Medicine, 2000 - 2003
  • M.Sc., Johns Hopkins University, 2008
  • M.D., University of Virginia School of Medicine, 2000
  • B.S.E., Duke University, 1996


Harrison, MR, and Armstrong, AJ. "Burden of disease matters when it comes to systemic therapy for prostate cancer." European urology 67, no. 3 (March 2015): 448-450.

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Shuch, B, Amin, A, Armstrong, AJ, Eble, JN, Ficarra, V, Lopez-Beltran, A, Martignoni, G, Rini, BI, and Kutikov, A. "Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity." European urology 67, no. 1 (January 2015): 85-97. (Review)

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Stewart, SB, Moul, JW, Polascik, TJ, Koontz, BF, Robertson, CN, Freedland, SJ, George, DJ, Lee, WR, Armstrong, AJ, and Bañez, LL. "Does the multidisciplinary approach improve oncological outcomes in men undergoing surgical treatment for prostate cancer?." International journal of urology : official journal of the Japanese Urological Association 21, no. 12 (December 2014): 1215-1219.

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Armstrong, AJ, Kaboteh, R, Carducci, MA, Damber, JE, Stadler, WM, Hansen, M, Edenbrandt, L, Forsberg, G, Nordle, Ö, Pili, R, and Morris, MJ. "Assessment of the bone scan index in a randomized placebo-controlled trial of tasquinimod in men with metastatic castration-resistant prostate cancer (mCRPC)." Urologic oncology 32, no. 8 (November 2014): 1308-1316.

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Sonpavde, G, Pond, GR, Armstrong, AJ, Clarke, SJ, Vardy, JL, Templeton, AJ, Wang, SL, Paolini, J, Chen, I, Chow-Maneval, E, Lechuga, M, Smith, MR, and Michaelson, MD. "Prognostic impact of the neutrophil-to-lymphocyte ratio in men with metastatic castration-resistant prostate cancer." Clinical genitourinary cancer 12, no. 5 (October 2014): 317-324.

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Bitting, RL, Schaeffer, D, Somarelli, JA, Garcia-Blanco, MA, and Armstrong, AJ. "The role of epithelial plasticity in prostate cancer dissemination and treatment resistance." Cancer Metastasis Rev 33, no. 2-3 (September 2014): 441-468. (Review)

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Bitting, RL, Healy, P, Creel, PA, Turnbull, J, Morris, K, Wood, SY, Hurwitz, HI, Starr, MD, Nixon, AB, Armstrong, AJ, and George, DJ. "A phase Ib study of combined VEGFR and mTOR inhibition with vatalanib and everolimus in patients with advanced renal cell carcinoma." Clinical genitourinary cancer 12, no. 4 (August 2014): 241-250.

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Ware, KE, Garcia-Blanco, MA, Armstrong, AJ, and Dehm, SM. "Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer." Endocrine-related cancer 21, no. 4 (August 2014): T87-T103. (Review)

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Aggarwal, R, Zhang, T, Small, EJ, and Armstrong, AJ. "Neuroendocrine prostate cancer: subtypes, biology, and clinical outcomes." Journal of the National Comprehensive Cancer Network : JNCCN 12, no. 5 (May 2014): 719-726. (Review)


Younis, IR, George, DJ, McManus, TJ, Hurwitz, H, Creel, P, Armstrong, AJ, Yu, JJ, Bacon, K, Hobbs, G, Peer, CJ, and Petros, WP. "Clinical pharmacology of an atrasentan and docetaxel regimen in men with hormone-refractory prostate cancer." Cancer chemotherapy and pharmacology 73, no. 5 (May 2014): 991-997.

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